A5038440555- Congenital heart defects research
- Olfactory and Sensory Function Studies
- Effects and risks of endocrine disrupting chemicals
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Developmental Biology and Gene Regulation
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Axon Guidance and Neuronal Signaling
- Receptor Mechanisms and Signaling
- Health, Environment, Cognitive Aging
- Genomic variations and chromosomal abnormalities
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Renin-Angiotensin System Studies
- Congenital Heart Disease Studies
- RNA Research and Splicing
- Congenital Diaphragmatic Hernia Studies
- Animal testing and alternatives
- Intensive Care Unit Cognitive Disorders
- Tracheal and airway disorders
George Washington University
2016-2023
Virginia Tech
2021
Biomedical Research Institute
2021
Ranbp1, a Ran GTPase-binding protein implicated in nuclear/cytoplasmic trafficking, is included within the DiGeorge/22q11.2 Deletion Syndrome (22q11.2 DS) critical region associated with behavioral impairments including autism and schizophrenia. Ranbp1 highly expressed developing forebrain ventricular/subventricular zone but has no known obligate function during brain development. We assessed role of targeted mouse mutant. Ranbp1−/− mice are not recovered live at birth, over 60% embryos...
Abstract Background Vitamin A regulates patterning of the pharyngeal arches, cranial nerves, and hindbrain that are essential for feeding swallowing. In LgDel mouse model 22q11.2 deletion syndrome (22q11DS), morphogenesis multiple structures involved in swallowing dysmorphic. We asked whether changes maternal dietary intake can modify nerve, arch artery development embryo as well lung pathology be a sign aspiration dysphagia pups. Methods Three defined amounts vitamin (4, 10, 16 IU/g) were...
Abstract Facial dysmorphology is a hallmark of 22q11.2 deletion syndrome (22q11DS). Nearly all affected individuals have facial features characteristic the syndrome: vertically long face with broad nasal bridge, narrow palpebral fissures and mild micrognathia, sometimes accompanied by skeletal oropharyngeal anomalies. Despite frequency craniofacial due to deletion, there still incomplete understanding contribution individual 22q11 genes development. We asked whether homozygous or...
We defined a temporally and transcriptionally divergent precursor cohort in the medial olfactory epithelium (OE) shortly after it differentiates as distinct tissue at mid-gestation mouse. This population of Ascl1+ cells dorsomedial OE is segregated from Meis1+/Pax7+ progenitors lateral OE, does not appear to be generated by Pax7+ precursors. The precursors do yield substantial number early-generated ORNs. Instead, they first generate additional proliferative well frontonasal mesenchymal...
There is a growing importance for environmental contributions to psychiatric disorders and understanding the impact of exposome (i.e., pollutants toxins). Increased biomonitoring epidemiological studies, example, suggest that daily phthalate chemical exposure contribute neurological behavioral abnormalities, however these mechanisms remain poorly understood. The current study therefore aimed examine effects chronic on rodent anxiety behaviors, cognition, hypothalamic-pituitary- adrenal...
Motivational cues of thirst, sleep, and hunger impact memory behavioral responses across species. Brain angiotensin II (AngII) is a potent thirst-producing peptide, where prior research demonstrated that receptor blocker affects conditioned fear memory. We therefore hypothesized acute water deprivation (WD) concurrent with blockage increases endogenous AngII levels contributes to retrieval plasticity.C57BL/6J male mice underwent both auditory contextual conditioning received single tone...
Abstract Background Hypertension is linked to Alzheimer’s Disease (AD) risk, although the mechanisms remain unclear. The renin angiotensin system (RAS), critical for blood pressure homeostasis, thought contribute AD pathology, and targeted RAS therapies are under current clinical investigation. To further evaluate neurobiological of in AD, study leveraged two transgenic mouse models compare behavioral cognitive deficits brain male female mice. Methods A triple‐transgenic model (3xTg‐AD),...
Background Memory formation is enhanced by stress and b-Adrenergic signaling largely involved in consolidation reconsolidation processes. Current FDA-approved drugs for the treatment of post-traumatic disorder (PTSD) are limited number efficacy. Pharmacological agents that modulate activity, such as propranolol, have shown some potential clinical utility treating PTSD. However, specific mechanisms activity on fear memory cardiac interoception unknown. In current study we investigated effects...
ABSTRACT We defined a temporal dimension of precursor diversity and lineage in the developing mouse olfactory epithelium (OE) at mid-gestation that results genesis distinct cell classes. Slow, symmetrically dividing Meis1+/ Pax7+ progenitors early differentiating lateral OE give rise to small numbers Ascl1+ precursors dorsolateral ventromedial OE. Few initial progeny immediately generate receptor neurons (ORNs). Instead, most this temporally cohort, labeled via discreet tamoxifen-dependent...