A5102862612- Evolution and Paleontology Studies
- Genetic Associations and Epidemiology
- Morphological variations and asymmetry
- Olfactory and Sensory Function Studies
- Pleistocene-Era Hominins and Archaeology
- Axon Guidance and Neuronal Signaling
- HIV Research and Treatment
- Evolution and Genetic Dynamics
- Race, Genetics, and Society
- Evolutionary Psychology and Human Behavior
- Forensic and Genetic Research
- Biomedical and Engineering Education
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Transgenic Plants and Applications
- Genetic diversity and population structure
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Lipid metabolism and disorders
- Primate Behavior and Ecology
- High Altitude and Hypoxia
- Genetic and phenotypic traits in livestock
- Genomic variations and chromosomal abnormalities
- Second Language Acquisition and Learning
- Neurogenesis and neuroplasticity mechanisms
European Association for the Study of Obesity
2024
University of North Carolina at Chapel Hill
2020
National Institutes of Health
2016-2019
National Human Genome Research Institute
2016-2019
George Washington University
2011-2018
National Institute of Diabetes and Digestive and Kidney Diseases
2018
Clemson University
2017
Genetic and archaeological studies have established a sub-Saharan African origin for anatomically modern humans with subsequent migrations out of Africa. Using the largest multi-locus data set known to date, we investigated genetic differentiation early humans, human admixture migration events, relationships among ancestries language groups. We compiled publicly available genome-wide genotype on 5,966 individuals from 282 global samples, representing 30 primary families. The best evidence...
A large brain is a defining feature of modern humans, yet there no consensus regarding the patterns, rates and processes involved in hominin size evolution. We use reliable proxy for fossils, endocranial volume (ECV), to better understand how evolved at both clade- lineage-level scales. For clade overall, dominant signal consistent with gradual increase size. This trend appears have been generated primarily by operating within hypothesized lineages—64% or 88% depending on whether one uses...
Abstract Per- and polyfluoroalkyl substances (PFAS) are “forever chemicals” pervasive environmental contaminants associated with cancer. Epidemiological studies found that an increased incidence of hormone-sensitive breast cancer is correlated PFAS exposure. Cell-based assays provide a well-controlled experimental platform to quantify cellular responses as function Given the nearly 15,000 known on Environmental Protection Agency's toxicity database (DSSTox), in vitro models only feasible...
We review the fossil and genetic evidence that relate to evolution in genus Homo. focus on origin of Homo for taxonomic diversity at beginning evolutionary history last 200,000 years. set out arguments recognizing a second early taxon, rudolfensis, against including habilis sensu stricto rudolfensis within end by reviewing recent genomic The challenge upcoming decades is meld innovations molecular methods technology with from record generate hypotheses about developmental bases phenotypic...
Objective The prevalence of obesity varies between ethnic groups. No genome‐wide association study (GWAS) for body mass index (BMI) has been conducted in continental Africans. Methods We performed a GWAS BMI 1,570 West Africans (WA). Replication was independent samples WA ( n = 1,411) and African Americans (AA) 9,020). Results identified novel significant African‐specific locus SEMA4D , rs80068415; minor allele frequency 0.008, P 2.10 × 10 −8 ). This finding replicated 0.013) AA 0.017)....
Genes encoding nuclear receptors (NRs) are attractive as candidates for investigating the evolution of gene regulation because they (1) have a direct effect on expression and (2) modulate many cellular processes that underlie development. We employed three-phase investigation linking NR molecular among primates with experimental assessment function. Phase 1 was an analysis domain results were used to guide design phase 2, codon-model-based survey alterations natural selection within...
Abstract This unit provides protocols for using the CODEML program from PAML package to make inferences about episodic natural selection in protein‐coding sequences. The cover inference tasks such as maximum likelihood estimation of intensity, testing hypothesis positive selection, and identifying sites with a history evolution. We provide rich set models implemented assess robustness, bootstrapping if requirements reliable statistical have been met. An example dataset is used illustrate how...
When prevalence rates of anemia exceed 40%, the World Health Organization recognizes this as a severe public health problem. In Peru, approximately 43.5% (urban) and 51.1% (rural) children between ages 6 36 months have anemia. Currently, limited data exists regarding in many high altitude regions Peru. The main purpose pilot study was to establish evidence infants (7 through 5 years age) living rural, mountainous region Ollantaytambo District. This utilized quantitative, cross-sectional...
Background: Angular insertion depth (AID) of the electrode array provides valuable information regarding intracochlear positioning, which can be used to predict outcomes and optimize performance. While computed tomography (CT) offers high-resolution imaging, there is a need develop technology accurately determine AID from intraoperative x-rays acquired at unknown angles. Methods: An algorithm was developed using three-dimensional model scala tympani estimate an x-ray angle. The manipulated...