A5101751003- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Medical Imaging and Analysis
- Head and Neck Cancer Studies
- Spine and Intervertebral Disc Pathology
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Advanced X-ray and CT Imaging
- Spinal Fractures and Fixation Techniques
- Testicular diseases and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Statistical Methods in Clinical Trials
Sichuan Cancer Hospital
2024
University of Electronic Science and Technology of China
2024
First Affiliated Hospital of Chengdu Medical College
2024
Zunyi Medical University
2023-2024
Cleveland Clinic
2013-2023
Dongguan People’s Hospital
2023
Guangdong Medical College
2023
Case Western Reserve University
2023
Riverside Methodist Hospital
2023
OhioHealth
2023
Allelic exclusion, one lymphocyte expresses antigen receptor, is a fundamental mechanism of immunological self-tolerance and highly specific immune responses to pathogens. However, the phenomenon V(D)J allelic inclusion (incomplete exclusion or escape) rearrangement dual TCR T cells have been discovered by multiple laboratories. Despite continuous new discoveries, proportion underlying has puzzling immunologists. In this study, we observed presence single expressing chains in all samples,...
Stereotactic body radiation therapy (SBRT) has been increasingly used as an efficacious treatment modality for early‐stage non‐small cell lung cancer. The accuracy of dose calculations is compromised due to the presence inhomogeneity. For purpose a consistent prescription, doses were calculated without heterogeneity correction in several RTOG trials. patients participating these trials, recalculations planned with more accurate methods could provide better correlations between outcomes and...
This paper adopts the ISM method to study structured teaching of chapter "Vegetation and Soil" in Humanistic Version High School Geography Compulsory 1. The knowledge structure textbook was analyzed by extracting core elements, determining relationships establishing adjacency matrix, forming hierarchical distribution table constructing systematic directed graph. Based on analysis results, a sequence activities unit framework were designed, aiming help students construct system. content this...
Purpose: Concurrent irradiation of the prostate and pelvic lymph nodes is technically challenging due to treating one moving target immobile target. The purposes this article are propose a new management strategy compare conventional isocenter shift method previously proposed MLC‐shifting method. Methods: To cope with two volumes (one immobile), authors referred as multiple adaptive plans (MAPs). This involves creation pool for number potential locations. Without requiring any additional...
Despite advancements in local and systemic therapy, metastasis remains common the natural history of sarcomas. Unfortunately, such metastases are most significant source morbidity mortality this heterogeneous disease. As a classically radioresistant histology, stereotactic radiosurgery has emerged to control spinal sarcomas provide palliation. However, there is lack data regarding pain relief relapse following radiosurgery.We queried retrospective institutional database patients who...
Background: Stereotactic body radiation therapy (SBRT) is increasingly used for patients with recurrent and or metastatic tumors. Sarcomas are generally considered not sensitive to radiotherapy SBRT may allow increased biological effectiveness. We report intermediate outcomes toxicity pediatric, adolescent, young adult treated sites of sarcoma Procedure: queried an Institutional Review Board-approved registry metastases from pediatric sarcomas. Patients age 29 below were assessed local...
The intricate origins, subsets, and characteristics of TCR (T Cell Receptor) s, along with the mechanisms underpinning antitumor response tumor-infiltrating T lymphocytes within tumor microenvironment (TME) remain enigmatic. Recently, advent single-cell RNA+TCR-sequencing (scRNA+TCR seq) has revolutionized TME analysis, providing unprecedented insight into cell CDR3 compositions, expression patterns response/depletion factors individual lymphocytes. Our analysis shared scRNA+TCR seq dataset...
Using multi-isocenter volumetric-modulated arc therapy (VMAT) for total body irradiation (TBI) may improve dose uniformity and vulnerable tissue protection compared with classical whole-body field technique. Two drawbacks limit its application: (1) VMAT-TBI planning is time consuming; (2) plans are sensitive to patient positioning uncertainties due beam matching. This study presents a robust technique image-guided delivery accuracy. In addition, streamlined sim-to-treat workflow automatic...
To monitor tumor motion during stereotactic body radiotherapy (SBRT) for patients with liver cancer, an integrated ultrasound and kilo-voltage cone-beam computed tomography (KV-CBCT) system has been proposed. The presence of probe may interfere the radiation beams. purpose this study is to minimize interference by altering orientations directions beams while not compromising quality SBRT plans. Ten patients, who received were randomly selected study. simulate probe, a virtual was oriented...
Purpose: Concurrent irradiation of the prostate and pelvic lymph nodes (PLNs) can be challenging due to independent motion two target volumes. To address this challenge, authors have proposed a strategy referred as Multiple Adaptive Planning (MAP). minimize number MAP plans, authors’ previous work only considered in one major direction. After analyzing pattern motion, investigated practical intensity‐modulated radiotherapy (IMRT) plans needed accommodate directions simultaneously. Methods:...
The APLAID syndrome is a rare primary immunodeficiency caused by gain-of-function mutations in the PLCG2 gene. We present 7-year-old patient who has recurrent blistering skin lesions, infections perineum, rectal perineal fistula, and inflammatory bowel disease. To determine genetic cause of our patient, WES bioinformatics analysis were performed. Flow cytometry was used for phenotyping immune cell populations peripheral blood. Cytokines released into plasma analyzed using protein chip...
As the most abundant protein in blood, human serum albumin (HSA) is usually regarded as an interferent clinical molecular diagnosis. Herein, we report that HSA endogenous signal amplifier for detection of prostate-specific antigen (PSA) plasma. This first study to utilize intrinsic biological components blood tests.
Abstract Purpose Volumetric‐modulated arc therapy for total body irradiation (VMAT‐TBI) is a novel radiotherapy technique that has been implemented at our institution. The purpose of this work to investigate possible failure modes (FMs) in the treatment process and develop quality control (QC) program VMAT‐TBI following TG‐100 guidelines. Methods We formed multidisciplinary team map out complete AAPM This gives visual representation workflow from CT simulation, image processing, contouring,...
In step‐and‐shoot IMRT plans, aperture‐based optimization (or one‐step optimization) has been considered as a means of improving monitor unit (MU) efficiency compared to fluence‐based two‐step optimization). However, the extent improvement on MU varies, depending implementation and design optimization. this paper, we attempted investigate issue in two methods implemented commercial treatment planning systems (TPSs). Five patients with nasopharyngeal cancer five advanced prostate were...
Purpose: The aim of the study was to evaluate impact multileaf collimator (MLC) leaf width on treatment adaptation and delivery accuracy for concurrent prostate pelvic lymph nodes with intensity modulated radiation therapy (IMRT). Methods: Seventy‐five kilovoltage cone beam CTs (KV‐CBCT) from six patients were included this retrospective study. For each patient, three different IMRT plans created based a planning CT using MLC widths 2.5, 5, 10 mm, respectively. CBCT, displacement determined...
There are limited data on spine stereotactic radiosurgery (SRS) in treating adolescent and young adult (AYA) patients. SRS has the advantages of highly conformal radiation dose delivery upfront retreatment settings, means for intensification, administration over a number sessions leading to decreased treatment burden. In this study, authors report oncological toxicity outcomes AYA patients with metastatic sarcoma treated provide clinicians guide considerations dose, volume, fractionation.
PURPOSE Improved survival prediction and risk stratification in non–small-cell lung cancer (NSCLC) would lead to better prognosis counseling, adjuvant therapy selection, clinical trial design. We propose the persistent homology (PHOM) score, radiomic quantification of solid tumor topology, as a solution. MATERIALS AND METHODS Patients diagnosed with stage I or II NSCLC primarily treated stereotactic body radiation (SBRT) were selected (N = 554). The PHOM score was calculated for each...