A5015678568- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Spine and Intervertebral Disc Pathology
- Glioma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Management of metastatic bone disease
- Spinal Fractures and Fixation Techniques
- Lung Cancer Research Studies
- Respiratory viral infections research
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Cervical and Thoracic Myelopathy
- Polyomavirus and related diseases
- Viral gastroenteritis research and epidemiology
- Musculoskeletal pain and rehabilitation
- SARS-CoV-2 detection and testing
- Meningioma and schwannoma management
- Crystallization and Solubility Studies
- Pelvic and Acetabular Injuries
Cleveland Clinic
2013-2025
Cleveland Clinic Lerner College of Medicine
2014-2024
St. Louis Children's Hospital
2020-2024
University of Cincinnati
2023-2024
Saint Luke's Health System
2024
University Hospitals Geauga Medical Center
2024
Cornell University
2024
Stanford University
2019-2023
The Wright Center for Graduate Medical Education
2023
Wilkes-Barre VA Medical Center
2023
The response of brain metastases (BM) treated with stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICIs; programmed cell death 1 its ligand) is significant interest.Patients were divided into cohorts based on ICI sequencing around SRS. primary outcome was best objective (BOR) that lesion specific. Secondary outcomes included overall (OOR), durability, radiation necrosis (RN), survival (OS).One hundred fifty patients underwent SRS to 1003 BM received ICI. Five sixty-four...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with concerning phenotypic mutations is public health interest. Genomic surveillance an important tool for a pandemic response, but many laboratories do not have the resources to support population-level sequencing. We hypothesized that nucleic acid amplification test (NAAT) genotype in viral spike protein could facilitate high-throughput variant surveillance. designed and analytically validated one-step...
Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. We collected plasma specimens July 2021 from 196 Mongolian participants fully vaccinated with one four COVID-19 vaccines: Pfizer/BioNTech, AstraZeneca, Sputnik V, and Sinopharm. Functional testing a panel nine viral variant receptor binding domain (RBD) proteins revealed marked differences vaccine responses, low levels RBD-ACE2 blocking...
Although mRNA-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines report >90% efficacy, breakthrough infections occur. Little is known about their effectiveness against SARS-CoV-2 variants, including the highly prevalent B.1.427/B.1.429 variant.
A meeting of experts was held in November 2021 to review and discuss available data on performance Epstein-Barr virus (EBV)-based approaches screen for early stage nasopharyngeal carcinoma (NPC) methods the investigation management screen-positive individuals. Serum EBV antibody plasma DNA testing were considered. Both found have favorable characteristics be cost-effective high-risk populations. In addition endoscopy, use magnetic resonance imaging (MRI) investigate individuals increase...
OBJECTIVE Improvements in imaging technology have steadily advanced surgical approaches. Within the field of spine surgery, assistance from O-arm Multidimensional Surgical Imaging System has been established to yield superior accuracy pedicle screw insertion compared with freehand and fluoroscopic Despite this evidence, no studies investigated clinical relevance associated increased accuracy. Accordingly, objective study was investigate outcomes following thoracolumbar spinal fusion...
OBJECTIVE The goal of this study was to investigate the impact stereotactic radiosurgery (SRS), BRAF status, and targeted immune-based therapies on recurrence patterns factors associated with overall survival (OS) among patients melanoma brain metastasis (MBM). METHODS A total 366 were treated for 1336 MBMs; a lesion-based analysis performed 793 SRS lesions. status available 78 patients: 35 had mut 43 wild-type ( BRAF-WT ) Kaplan-Meier method evaluated unadjusted OS; cumulative incidence...
BACKGROUND The current study was conducted to investigate survival and the response radiotherapy among patients with molecular subtypes of breast cancer brain metastases treated or without targeted therapies. METHODS Patients diagnosed at a single tertiary care institution were included. primary outcome overall survival, whereas secondary outcomes included cumulative incidences distant intracranial failure, local radiation necrosis. Competing risks regression used model outcomes. RESULTS...
This study compares surgical site infections and costs of care for patients undergoing spinal surgery before after implementation an infection prevention bundle in the neurosurgical unit Cleveland Clinic.
OBJECT Systemic control of metastatic renal cell carcinoma (mRCC) has substantially improved with the development VEGF, mTOR, and checkpoint inhibitors. The current first-line standard care is a VEGF tyrosine kinase inhibitor (TKI). In preclinical models, TKIs potentiate response to radiotherapy. Such efficacy may prolong time salvage therapies, including whole-brain radiotherapy or second-line systemic therapy. As prevalence mRCC increased, utilization spine stereotactic radiosurgery (SRS)...
The object of this retrospective study was to investigate the impact targeted therapies on overall survival (OS), distant intracranial failure, local and radiation necrosis among patients treated with therapy for renal cell carcinoma (RCC) metastases brain.
With increasing survival for patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer in the trastuzumab era, there is an increased risk of brain metastasis. Therefore, interest optimizing intracranial disease control. Lapatinib a small-molecule dual HER2/epidermal inhibitor that has demonstrated activity against HER2+ metastases. The objective this study was to investigate impact lapatinib combined stereotactic radiosurgery (SRS) on local control
Patients with breast cancer positive for human epidermal growth factor receptor 2 (HER2) remain at high risk of intracranial relapse following treatment and experience increased rates failure after stereotactic radiosurgery (SRS). We hypothesized that the addition concurrent lapatinib to SRS would improve complete response rates. newly diagnosed HER2-amplified brain metastases from 2005–2014 who underwent were included divided into cohorts based on timing lapatinib. Outcome variables...
Our institution cancelled all in-person clerkships owing to the coronavirus disease 2019 pandemic. In response, we designed a virtual radiation oncology medical student clerkship.We convened an advisory panel design clerkship curriculum. We implemented activities using cloud-based learning management system, video web conferencing systems, and telemedicine portal. Students completed assessments pre- postclerkship provide data improve future versions of clerkship.The spans 2 weeks is graded...
Abstract Background Distribution of mRNA-based SARS-CoV-2 vaccines to healthcare personnel (HCP) in the United States began December 2020, with efficacy > 90%. However, breakthrough infections fully vaccinated individuals have been reported. Meanwhile, multiple variants concern emerged worldwide, including B.1.427/B.1.429 variant first described California. Little is known about real-world effectiveness against novel B.1.427/B.1.429. Methods In this quality improvement project,...