A5102766809- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Toxin Mechanisms and Immunotoxins
- Bioactive Compounds and Antitumor Agents
- Oral Health Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
- Nuts composition and effects
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
Affiliated Hospital of Qingdao University
2021-2023
Qingdao University
2021-2023
Abstract Background The recurrent aphthous stomatitis (RAS) frequently affects patient quality of life as a result long lasting and episodes burning pain. However, there were temporarily few available effective medical therapies currently. Drug target identification was the first step in drug discovery, usually finding best interaction mode between potential candidates probe small molecules. Therefore, elucidating molecular mechanism RAS pathogenesis exploring targets for vital importance....
Abstract Previous studies have shown that benzoylaconine (BAC), a representative monoester alkaloid, has potential anti-inflammatory effect. This study investigated the underlying molecular mechanisms using mode of LPS-activated RAW264.7 macrophage cells. Our findings showed BAC significantly suppressed release pro-inflammatory cytokines and mediators, including IL-6, TNF-α, IL-1β, ROS, NO, PGE 2 . treatment also effectively downregulated elevated protein levels iNOS COX-2 induced by LPS in...
Abstract At present, the recurrent aphthous stomatitis (RAS) are not completely clear. Therefore, identifying underlying diagnostic biomarkers of RAS can provide new ideas for diagnosis and treatment RAS. The gene chip data (GSE37265) were downloaded from NCBI Gene Expression Omnibus (GEO) database. Weighted Co-Expression Network Analysis (WGCNA) was used to construct a co-expression module. A total 16 modules identified, 30 hub genes in turquoise module identified. In addition, functional...