A5064272570- Electrocatalysts for Energy Conversion
- Natural product bioactivities and synthesis
- Fuel Cells and Related Materials
- Catalytic Processes in Materials Science
- NF-κB Signaling Pathways
- Advancements in Battery Materials
- Toxin Mechanisms and Immunotoxins
- Advanced battery technologies research
- Cytokine Signaling Pathways and Interactions
- Catalysts for Methane Reforming
- Advanced Battery Technologies Research
- Supercapacitor Materials and Fabrication
- CO2 Reduction Techniques and Catalysts
- Bioactive Compounds and Antitumor Agents
- Advanced Photocatalysis Techniques
- Advanced Battery Materials and Technologies
- Viral-associated cancers and disorders
- Immune Response and Inflammation
- Infectious Diseases and Mycology
- Clinical practice guidelines implementation
- Autophagy in Disease and Therapy
- Renal Transplantation Outcomes and Treatments
- Melanoma and MAPK Pathways
- Catalysis for Biomass Conversion
- Ionic liquids properties and applications
Nanjing University
2023-2025
Affiliated Hospital of Qingdao University
2019-2024
Qingdao University
2019-2024
Nantong University
2017-2019
Second People's Hospital of NanTong
2017-2019
Cutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy. MicroRNA-221 (miRNA-221) critical non-coding RNA in tumor initiation and progression. However, the molecular mechanisms miRNA-221 development CSCC remain unknown. This study investigated expression its potential biological functions. MTT assay, colony PCR, Western blot were adopted. In this study, was significantly higher tissues lines than normal cells (P < 0.05). Further functional experiments indicated that...
Renewable-driven electrochemical CO2 reduction reaction (CO2RR) to syngas is an encouraging alternative strategy traditional fossil fuel-based production, and the development of industrial-level electrocatalysts vital. Herein, based on theoretical optimization metal species, hierarchical CoxNi1-x-N-C dual single-atom catalyst (DSAC) with individual NiN4 (CO preferential) CoN4 (H2 moieties was constructed by a two-step pyrolysis route. The Co0.5Ni0.5-N-C exhibits stable CO Faradaic efficiency...
Cisplatin (CDDP)-based chemotherapy is a standard treatment for gastric cancer (GC). However, chemoresistance major obstacle CDDP application. Exploring underlying mechanisms of resistance development in GCand selecting an effective strategy to overcome remain challenge.Here, we demonstrate that transmembrane ectoenzyme, CD13, endows GC patients with insensitivity and predicts undesirable prognosis treatment.Similarly, CD13 expression positively related cells.A inhibitor, Ubenimex, reverses...
Engineering microstructures of Pt and understanding the related catalytic mechanism are critical to optimizing performance for hydrogen evolution reaction (HER). Herein, dispersion coordination precisely regulated on hierarchical nitrogen-doped carbon nanocages (hNCNCs) by a thermal-driven migration, from edge-hosted Pt–N2Cl2 single sites in initial Pt1/hNCNC-70 °C catalyst clusters/nanoparticles back in-plane Pt–NxC4–x sites. Thereinto, presents optimal HER activity (6 mV@10 mA cm–2) while...
Ammonia synthesis via nitrate electroreduction is more attractive and sustainable than the energy-extensive Haber-Bosch process intrinsically sluggish nitrogen electroreduction. Herein, we have designed a single-site Cu catalyst on hierarchical nitrogen-doped carbon nanocage support (Cu1/hNCNC) for electroreduction, which achieves an ultrahigh ammonia yield rate (YRNH3) of 99.4 mol h-1 gCu-1 (2.30 gcat.-1) with Faradaic efficiency (FENH3) 99.3%, far beyond most reported catalysts...
The N-doped carbon nanocages-supported Pt nanoparticle catalyst exhibits high activity and stability for preferential oxidation of CO in H 2 over a wide temperature range 80~180 ℃, which is attributed...
Benzoylmesaconine (BMA), the most abundant monoester alkaloid in Aconitum plants, has some biological activities and is a potential therapeutic agent for inflammation-related diseases. However, anti-inflammatory mechanisms of BMA have not been clarified.This study aimed to investigate underlying molecular action this compound using lipopolysaccharide (LPS)-activated RAW264.7 macrophages.The release pro-inflammatory cytokines mediators were detected by nitric oxide (NO) assays, reactive...
Taking the advantages of hierarchical nitrogen-doped carbon nanocages (hNCNCs) with nanocavities for encapsulation and multiscale micro-meso-macropores/high conductivity mass/electron synergistic transportation, a conversion-type CuO anode material is confined inside hNCNCs potassium storage. The so-obtained yolk-shelled CuO@hNCNC hybrids have tunable contents in range 11.7-63.7 wt%. unique architecture leads to loss-free pulverization active components during charge/discharge, which...
Background: Gastric cancer (GC) is one of the most common malignant tumors in China.Most GC patients are diagnosed at an advanced stage, for that prognosis dismal and metastasis common.Although there have been increasing numbers studies indicating Ubenimex can suppress GC, underlying mechanism still unknown.Methods: Herein, inhibitory effect on metastasis, which underlining was determined using Gene chip analysis, high content screening (HCS), transwell assays, wound healing assays Western...
Abstract Background The recurrent aphthous stomatitis (RAS) frequently affects patient quality of life as a result long lasting and episodes burning pain. However, there were temporarily few available effective medical therapies currently. Drug target identification was the first step in drug discovery, usually finding best interaction mode between potential candidates probe small molecules. Therefore, elucidating molecular mechanism RAS pathogenesis exploring targets for vital importance....
Primary diffuse large B-cell lymphoma of the bone (PB-DLBCL) is an extremely rare type extra-nodal lymphoma. The clinical characteristics, management, and survival outcomes adult PB-DLBCL patients remain poorly defined. To explore manifestations, staging, therapeutic options, prognostic factors with to create a model predict outcomes. Data were obtained from Surveillance, Epidemiology, End Results (SEER) Program 18 registries database 2000 2018. Kaplan–Meier analysis was conducted calculate...
Objective: Using perioperative VTE prophylactic anticoagulant pathway delicacy management, we aimed to explore the role of clinical pharmacists in treatment and effect medicine implementation. Methods: In compliance with evidence-based medicine, combined practice, participated formulation pathway. The PDCA cycle was strictly implemented. Urologic Department, Affiliated Hospital Qingdao University, Shandong, China, served as a pilot department for evaluation drug Results: urologic formulated...
Malignancy is a common cause of death in renal transplant patients. The aim this study was to investigate incidence, risk factors, and survival rates associated with posttransplant malignancy kidney recipients.Between January 2015 December 2020, 1154 patients underwent at the Affiliated Hospital Qingdao University. Patients history or other organ transplant(liver, pancreas, heart, orlungs) were excluded from study. incomplete follow-up records also excluded. Ultimately, our comprised 811...
Abstract Previous studies have shown that benzoylaconine (BAC), a representative monoester alkaloid, has potential anti-inflammatory effect. This study investigated the underlying molecular mechanisms using mode of LPS-activated RAW264.7 macrophage cells. Our findings showed BAC significantly suppressed release pro-inflammatory cytokines and mediators, including IL-6, TNF-α, IL-1β, ROS, NO, PGE 2 . treatment also effectively downregulated elevated protein levels iNOS COX-2 induced by LPS in...
Proton exchange membrane fuel cell (PEMFC) has great commercialization prospects. To reduce the cost of PEMFC, constructing high-performance electrode assembly (MEA) with low Pt areal loading is critical. Herein, a series catalysts weight fraction 40~80 wt.% were synthesized by using hierarchical carbon nanocages (hCNC) and N-doped hCNC (hNCNC) as supports. The nanoparticles on hNCNC (Pt/hNCNC) exhibited superior oxygen reduction reaction (ORR) activity stability to those in half cells....
Abstract At present, the recurrent aphthous stomatitis (RAS) are not completely clear. Therefore, identifying underlying diagnostic biomarkers of RAS can provide new ideas for diagnosis and treatment RAS. The gene chip data (GSE37265) were downloaded from NCBI Gene Expression Omnibus (GEO) database. Weighted Co-Expression Network Analysis (WGCNA) was used to construct a co-expression module. A total 16 modules identified, 30 hub genes in turquoise module identified. In addition, functional...