A5077552856- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Ion channel regulation and function
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Cholinesterase and Neurodegenerative Diseases
- Neurobiology and Insect Physiology Research
- Venomous Animal Envenomation and Studies
- COVID-19 and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Epilepsy research and treatment
- Neurological disorders and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Protein Kinase Regulation and GTPase Signaling
- Neurogenesis and neuroplasticity mechanisms
- Academic Publishing and Open Access
- Electrochemical Analysis and Applications
- Perfectionism, Procrastination, Anxiety Studies
- Pharmacogenetics and Drug Metabolism
- Long-Term Effects of COVID-19
- Academic Writing and Publishing
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Lipid Membrane Structure and Behavior
- Beetle Biology and Toxicology Studies
Universidade de São Paulo
2014-2025
Universidade de Ribeirão Preto
2022-2025
Aarhus University
2024-2025
University of Chile
1998-2025
Instituto de Neurociências e Comportamento
2014-2019
Brown University
2019
Stressful events can cause a significant impact on education; however, it is not yet clear how the interplay between anxiety, work, and social dysfunction relates to learning impairments. In this study, we investigated of COVID-19 pandemic students’ mental health. This study was conducted during four modules remote Psychopharmacology course 5 October 20 December 2020. We collected data from 28 Psychology undergraduate students at University São Paulo, Brazil. used pre- post-test...
Early life adversity (ELA) is associated with altered neural development and increased risk for the of psychopathology across lifespan. Rodent models ELA are an important tool investigating possible mechanistic underpinnings pathology development. We used a limited bedding nesting model (LBN) to induce stress in dam alter dam-pup interactions during sensitive period early postnatal The primary characteristics previously identified this include fragmented unpredictable maternal care possibly...
This study examined the psychometric properties of a Brazilian adapted version Coronavirus Anxiety Scale (CAS-BR) in sample adults Brazil. Confirmatory factor analyses demonstrated that CAS-BR produces reliable (α = .84), unidimensional construct whose structure was shown to be invariant across gender, race, and age. However, some items were stronger indicators coronavirus anxiety for women younger adults. Although evidence discrimination ability functional impairment (AUC .77), Youden...
This study presents a 50-year hydrodynamic simulation of Laguna Carén, shallow lake near the capital Chile, utilizing 3-Dimensional coupled Hydrodynamic-Aquatic Ecosystem Model, AEM3D, to investigate factors influencing mixing regimes water column. The model incorporates key processes, such as heat and momentum exchanges with atmosphere, light penetration, diffusion in sediments, all fundamental for understanding hydrodynamics lake. obtained results allowed classifying regime rarely mixed...
Motor symptoms of Parkinson's disease (PD)-bradykinesia, akinesia, and tremor at rest-are consequences the neurodegeneration dopaminergic neurons in substantia nigra pars compacta (SNc) striatal deficit. Animal models have been widely used to simulate human pathology laboratory. Rodents are most animal for PD due their ease handling maintenance. Moreover, anatomy molecular, cellular, pharmacological mechanisms similar rodents humans. The infusion neurotoxin, 6-hydroxydopamine (6-OHDA), into...
Abstract Toxic effects of several nitro‐aryl drugs are attributed to the nitro‐reduction that may be suffered in vivo , a reaction catalysed by different reductases. One these enzymes is NADPH–cytochrome P450 reductase, which belongs cytochrome oxidative system mainly localized endoplasmic reticulum hepatic cell. This responsible for biotransformation lipophilic compounds, so and reductive metabolic pathways can take place simultaneously. Because affinity (xenobiotics) reticulum, we propose...
(1) Background: Temporal lobe epilepsy (TLE) is the most common type of in adults. It also one with highest percentage drug-resistance to current available anti-epileptic drugs (AED). Additionaly, antiepileptic are only able control seizures epileptogenesis, but do not decrease hippocampal neurodegenerative process. TLE patients have a reduced population interneuronal cells, which express Parvalbumin (PV) proteins. This reduction directly linked seizure frequency and severity chronic period...
Polyamines are compounds that interact with ionotropic receptors, mainly modulating the NMDA receptor, which is strictly related to many neurologic diseases such as epilepsy. Consequently, polyamines rise potential neuropharmacological tools in prospection of new therapeutic drugs. In this paper, we report on biological activity synthetic polyamine Mygalin, was tested an anticonvulsant model chemically induced seizures. Male Wistar rats were injected vehicle, diazepam, MK-801 or Mygalin at...
Epilepsy is considered as one of the major disabling neuropathologies. Almost third adult patients with temporal lobe epilepsy (TLE) do not respond to current antiepileptic drugs (AEDs). Additionally, most AEDs have neuroprotective effects against inherent neurodegenerative process underlying hippocampal sclerosis on TLE. Dysfunctions in GABAergic neurotransmission may contribute only onset epileptic activity but also constitute an important system for therapeutic approaches. Therefore,...
Motor symptoms of Parkinson's disease (PD)-bradykinesia, akinesia, and tremor at rest-are consequences the neurodegeneration dopaminergic neurons in substantia nigra pars compacta (SNc) striatal deficit. Animal models have been widely used to simulate human pathology laboratory. Rodents are most animal for PD due their ease handling maintenance. Moreover, anatomy molecular, cellular, pharmacological mechanisms similar rodents humans. The infusion neurotoxin, 6-hydroxydopamine (6-OHDA), into...
Studies on toad poison are relevant since they considered a good source of toxins that act different biological systems. Among the molecules found in poison, it can be highlighted cardiotonic heterosides, which have known mechanism inhibit Na+/K+-ATPase enzyme. However, these poisons many other may important actions. Therefore, this work evaluated action low molecular weight components from Rhinella schneideri and their anticonvulsive / or neurotoxic effects, order to detect with actions...
The facilitation of corticostriatal transmission is modulated by the pharmacological inhibition striatal phosphodiesterase 10A (PDE10A). Since L-DOPA-induced dyskinesia associated with abnormal transmission, we hypothesized that PDE10A would modulate (LID) regulating activity. 6-OHDA-lesioned rats were chronically treated L-DOPA for one week. After that, two additional weeks, animals inhibitor PDM-042 (1 and 3 mg/kg) hour before L-DOPA. Behavioral analyses performed to quantify involuntary...