A5062476480- Bioinformatics and Genomic Networks
- Gene Regulatory Network Analysis
- Oceanographic and Atmospheric Processes
- Microbial Metabolic Engineering and Bioproduction
- Plant Water Relations and Carbon Dynamics
- Gene expression and cancer classification
- Climate variability and models
- Meteorological Phenomena and Simulations
- Hydrology and Watershed Management Studies
- Ocean Waves and Remote Sensing
- Metabolomics and Mass Spectrometry Studies
- Geological formations and processes
- Fish Ecology and Management Studies
- Marine and coastal ecosystems
- Aquatic Ecosystems and Phytoplankton Dynamics
- Genetics, Bioinformatics, and Biomedical Research
- Computational Drug Discovery Methods
- Advanced Proteomics Techniques and Applications
- Cryospheric studies and observations
- Methane Hydrates and Related Phenomena
- Genetic Mapping and Diversity in Plants and Animals
- Water resources management and optimization
- Flood Risk Assessment and Management
- Atmospheric and Environmental Gas Dynamics
- Hydrocarbon exploration and reservoir analysis
University of Chile
2013-2025
Universidad de Santiago de Chile
2008-2020
Research Institute for Farm Animal Biology (FBN)
2013-2016
Zimmer Biomet (Germany)
2013-2015
Leibniz Association
2013
Virginia Tech
2002-2011
Center for Advanced Studies Research and Development in Sardinia
2010-2011
The University of Western Australia
2010
Centro di Riferimento Oncologico
2009
Abstract Motivation: A major challenge of systems biology is to infer biochemical interactions from large-scale observations, such as transcriptomics, proteomics and metabolomics. We propose use a partial correlation analysis construct approximate Undirected Dependency Graphs data. This approach enables distinction between direct indirect compounds, thereby inferring the underlying network topology. Results: The method first thoroughly evaluated with large set simulated Results indicate that...
DNA methylation is one of several epigenetic mechanisms that contribute to the regulation gene expression; however, extent which CpG dinucleotides correlates with expression at genome-wide level still largely unknown. Using purified primary monocytes from subjects in a large community-based cohort (n = 1264), we characterized (>485 000 sites) and mRNA (>48K transcripts) carried out association analyses 8370 phenotypes. We identified 11 203 potential cis-acting loci whose degree was...
Obesity is linked to type 2 diabetes (T2D) and cardiovascular diseases; however, the underlying molecular mechanisms remain unclear. We aimed identify obesity-associated features that may contribute obesity-related diseases. Using circulating monocytes from 1,264 Multi-Ethnic Study of Atherosclerosis (MESA) participants, we quantified transcriptome epigenome. discovered alterations in a network coexpressed cholesterol metabolism genes are signature feature obesity inflammatory stress. This...
Our goal is gene network inference in genetical genomics or systems genetics experiments. For species where sequence information available, we first perform expression quantitative trait locus (eQTL) mapping by jointly utilizing cis-, cis-trans-, and trans-regulation. After using local structural models to identify regulator-target pairs for each eQTL, construct an encompassing directed (EDN) assembling all retained relationships. The EDN has nodes corresponding expressed genes eQTL edges...
Background Reverse-engineering gene networks from expression profiles is a difficult problem for which multitude of techniques have been developed over the last decade. The yearly organized DREAM challenges allow fair evaluation and unbiased comparison these methods. Results We propose an inference algorithm that combines confidence matrices, computed as standard scores single-gene knockout data, with down-ranking feed-forward edges. Substantial improvements on predictions can be obtained...
The effect of lake geometry on wind‐induced upwelling, in a two‐layer stratified with variable bottom slope and generic planar shape is investigated. (1) traditional linearized classification parameter for the Wedderburn number, extended to include finite amplitude effects rectangular basin; this extension important when number < ~3. (2) generalized incorporate influence variable‐width basin both linear (large number) nonlinear (small assumptions. Laboratory numerical experiments...
Transcriptomic studies hold great potential towards understanding the human aging process. Previous transcriptomic have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often make these results difficult to interpret. Using profiles in CD14+ monocytes from 1,264 participants of Multi-Ethnic Study Atherosclerosis (aged 55–94 years), we 2,704 differentially expressed chronological age (false discovery rate, FDR ≤ 0.001). We further...
High Andean wetlands of the elevated plateaus Andes Mountains Chile, Argentina, Perú and Bolivia are true oases that sustain life in this arid region. Despite their ecological value, they have been rarely studied vulnerable to climate change human activities require groundwater resources. One such activity may be intensified near future is mining for nonmetallic minerals as lithium, whose worldwide demand expected increase with rise electric vehicles need batteries. To determine a baseline...
This study presents a 50-year hydrodynamic simulation of Laguna Carén, shallow lake near the capital Chile, utilizing 3-Dimensional coupled Hydrodynamic-Aquatic Ecosystem Model, AEM3D, to investigate factors influencing mixing regimes water column. The model incorporates key processes, such as heat and momentum exchanges with atmosphere, light penetration, diffusion in sediments, all fundamental for understanding hydrodynamics lake. obtained results allowed classifying regime rarely mixed...
The intensification of the hydrological cycle because global warming raises concerns about future floods and their impact on large cities where exposure to these events has also increased. development adequate adaptation solutions such as early warning systems is crucial. Here, we used deep learning (DL) for weather-runoff forecasting in región Metropolitana Chile, a urban area valley at foot Andes Mountains, with more than 7 million inhabitants. final goal this research develop an effective...
The hydrodynamics of many hydropower reservoirs are controlled by the operation their power plant, but associated water quality impact is often poorly understood. In particular, significant hydropeaking operations plants affect not only downstream ecosystem also reservoir temperature. This paper contributes to understanding that link. For this, we coupled a hydrodynamic model (Estuary, Lake and Coastal Ocean Model, ELCOM) grid-wide system scheduling model. case study (Rapel, Chile), observe...
In the endorheic basins of Altiplano, water is crucial for sustaining unique ecological habitats. Here, wetlands act as highly localized evaporative environments, and little known about processes that control evaporation. Understanding evaporation in Altiplano challenging because these environments are immersed a complex topography surrounded by desert affected atmospheric circulations at various spatial scales. Also, may be subject to enhancement events result dry air advection. To better...
Abstract. We investigate the influence of regional atmospheric circulation on evaporation a saline lake in Altiplano (also known as Andean Plateau) region Atacama Desert. For that, we conducted field experiment Salar del Huasco (SDH) basin (135 km east Pacific Ocean), November 2018. The measurements were based surface energy balance (SEB) stations and airborne observations. Additionally, simulate meteorological conditions scale using Weather Research Forecasting Model. Our findings show two...
Abstract Summary: SysGenSIM is a software package to simulate Systems Genetics (SG) experiments in model organisms, for the purpose of evaluating and comparing statistical computational methods their implementations analyses SG data [e.g. expression quantitative trait loci (eQTL) mapping network inference]. allows user select variety topologies, genetic kinetic parameters ( genotyping, gene phenotyping) with large networks thousands nodes. The encoded MATLAB, user-friendly graphical...
Dissolved oxygen (DO) and heat exchanges across the water-sediment interface (WSI) of a shallow lagoon are controlled by processes occurring on both sides WSI, particularly volumetric source sink sediment side turbulent transport waterside.This article presents analyzes measurements DO (J s ) (H g fluxes WSI in extremely Salar del Huasco (20.274°S, 68.883°W, 3800 m above sea level), where exists layer, related to benthic primary production absorption solar radiation,...