A5102740815- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Bone fractures and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Musculoskeletal Disorders and Rehabilitation
- Genetic Neurodegenerative Diseases
- Cancer-related gene regulation
- Melanoma and MAPK Pathways
- Cholesterol and Lipid Metabolism
- Nuclear Structure and Function
- Sirtuins and Resveratrol in Medicine
- Hip and Femur Fractures
- Skin Protection and Aging
- Plant Water Relations and Carbon Dynamics
- Smoking Behavior and Cessation
- Protein Kinase Regulation and GTPase Signaling
Cleveland State University
2024
Brown University
2020-2024
Australian National University
2023
Children's Hospital of Philadelphia
2018
The University of Texas Southwestern Medical Center
2018
Wake Forest University
2009-2017
National Center for Geriatrics and Gerontology
2014
Winston-Salem State University
2012
East Carolina University
2008-2011
Tobacco smoke contains numerous agonists of the aryl hydrocarbon receptor (AhR) pathway, and activation AhR pathway was shown to promote atherosclerosis in mice. Intriguingly, cigarette smoking is most strongly robustly associated with DNA modifications an gene, repressor (AHRR). We hypothesized that altered AHRR methylation monocytes, a cell type sensitive involved atherogenesis, may be part biological link between atherosclerosis.DNA profiles monocytes (542 CpG sites ± 150 kb AHRR, using...
Sirt6 is a multifunctional enzyme that regulates diverse cellular processes such as metabolism, DNA repair, and aging. Overexpressing extends lifespan in mice, but the underlying mechanisms are unclear. Drosophila melanogaster an excellent model to study genetic regulation of lifespan; however, despite extensive mammals, very little known about function flies. Here, we characterized ortholog Sirt6, dSirt6, examined its role regulating longevity; dSirt6 nuclear chromatin-associated protein...
Transcriptomic studies hold great potential towards understanding the human aging process. Previous transcriptomic have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often make these results difficult to interpret. Using profiles in CD14+ monocytes from 1,264 participants of Multi-Ethnic Study Atherosclerosis (aged 55–94 years), we 2,704 differentially expressed chronological age (false discovery rate, FDR ≤ 0.001). We further...
The purpose of this study was to compare the accuracy different methods used predict ultimate leg lengths and residual leg-length discrepancy in a group patients treated with epiphysiodesis at our institution.Seventy-seven adequate preoperative radiographs, no postoperative complications, follow-up skeletal maturity composed group. We compared predicted both legs actual outcomes using White-Menelaus, Anderson-Green, Moseley, multiplier methods.Skeletal age varied >1 year from chronological...
Jackson R. Taylor 1* , Brian D. Lehmann 2# William H. Chappell 1 Stephen L. Abrams Linda S. Steelman and James A. McCubrey Department of Microbiology & Immunology, Brody School Medicine at East Carolina University Greenville, NC 27858 USA 2 Anatomy Cell Biology, University, * Current Address: Wake Forest Winston-Salem, NC, # Vanderbilt Nashville, TN, Received: August 26, 2011; Accepted: 30, Published: Keywords: Akt, ERK, mTOR, Senescence, Drug Resistance, Tamoxifen Correspondence: McCubrey,...
BACKGROUNDPreclinical studies suggest that cholesterol accumulation leads to insulin resistance. We previously reported alterations in a monocyte metabolism transcriptional network (CMTN) - suggestive of cellular were cross-sectionally associated with obesity and type 2 diabetes (T2D). Here, we sought determine whether the CMTN independently predict incident prediabetes/T2D risk, correlate accumulation.METHODSMonocyte mRNA expression 11 genes was quantified among 934 Multi-Ethnic Study...
Ca2+ release from the sarcoplasmic reticulum (SR) into cytosol is a crucial part of excitation-contraction (E-C) coupling. Excitation-contraction uncoupling, deficit in SR, thought to be responsible for at least some loss specific force observed aging skeletal muscle. uncoupling may caused by alterations expression voltage-dependent calcium channel alpha1s (CaV1.1) and beta1a (CaVbeta1a) subunits, both which are necessary E-C coupling occur. While previous studies have found CaV1.1 declines...
Voltage-gated calcium channel (Cav) β subunits are auxiliary to Cavs. Recent reports show Cavβ may enter the nucleus and suggest a role in transcriptional regulation, but physiological relevance of this localization remains unclear. We sought define nuclear function muscle progenitor cells (MPCs). found that Cavβ1a is expressed proliferating MPCs, before expression conducting subunit Cav1.1, enters nucleus. Loss impaired MPC expansion vitro vivo caused widespread changes global gene...
CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if how these differences reflected at transcriptomic level. We performed microarray profiling on RNA derived from (CD44low) (CD44high) young (2–3 month) old (28 mice, in order to better understand mechanisms age-related functional alterations both subsets. also follow-up bioinformatic analyses determine consequences gene expression changes identify...
Abstract The Midwest Aging Consortium (MAC) has emerged as a critical collaborative initiative aimed at advancing our understanding of aging and developing strategies to combat the rising prevalence age-related diseases. Founded in 2019, MAC brings together researchers from various disciplines institutions across Midwestern United States foster interdisciplinary geroscience research. This report summarizes highlights Fourth Annual Symposium MAC, which was held Iowa State University May 2023....
As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate mechanisms and precipitate development of therapeutic interventions to support healthy aging. The Fifth Annual Midwest Aging Consortium Research symposium, held from April 28-30, 2024, was hosted Ohio State University in Columbus, featured presentations investigators across Midwestern United States. This report summarizes presented...