A5004674881- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and biosynthesis
- Axon Guidance and Neuronal Signaling
- Neurobiology and Insect Physiology Research
- Cellular Mechanics and Interactions
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Apelin-related biomedical research
- Wnt/β-catenin signaling in development and cancer
- Glutathione Transferases and Polymorphisms
- CRISPR and Genetic Engineering
- Photosynthetic Processes and Mechanisms
- Reproductive Biology and Fertility
- Viral Infectious Diseases and Gene Expression in Insects
- Pancreatic function and diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Skin Protection and Aging
- Global Public Health Policies and Epidemiology
- Global Cancer Incidence and Screening
- Data-Driven Disease Surveillance
- 3D Printing in Biomedical Research
- Sperm and Testicular Function
University of Louisville
2024
University of California, Los Angeles
2014-2022
University of Kansas
2008-2018
Lawrence University
2018
UCLA Health
2018
Institut thématique Génétique, génomique et bioinformatique
2010-2011
The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone during axon extension remain mysterious. Rho-family GTPases Rac and CDC-42 are key regulators of lamellipodia filopodia formation, yet little is understood about how these molecules interact outgrowth or activities regulated distinct contexts. UNC-73/Trio a well-characterized GTP exchange factor Caenorhabditis elegans pathfinding, UNC-73 does not control CED-10/Rac downstream UNC-6/Netrin attractive...
Abstract In the developing nervous system, axons are guided to their targets by growth cone. Lamellipodial and filopodial protrusions from cone underlie motility guidance. Many molecules that control lamellipodia filopodia formation, actin organization, axon guidance have been identified, but it remains unclear how these act together events. Experiments described here indicate that, in Caenorhabditis elegans, two WH2-domain-containing activators of Arp2/3 complex, WVE-1/WAVE WSP-1/WASP,...
It is estimated that more than 600,000 new cases of cancer will be reported in Brazil during the 2018-2019 biennium, especially with regard to prostate, breast, lung and colorectal cancers. Due high prevalence, incidence mortality rates these diseases, campaigns such as 'Pink October' 'Blue November' were strongly promoted past decade throughout country raise awareness breast prostate cancer, respectively. Nevertheless, whether implementation has been proven efficient still unknown. In...
Highlights•Autophagy is required for regulating CySC maintenance and cyst cell function•EGFR signaling stimulates autophagy to control early CC behavior•Autophagy suppression by TOR in CCs somatic/germline differentiation•Defective results lipid accumulation loss of cellsSummaryAlthough typically upregulated upon cellular stress, can also be utilized under homeostatic conditions as a quality mechanism or response developmental cues. Here, we report that the somatic stem cells (CySCs)...
Abstract Mitochondria are essential organelles that have recently emerged as hubs for several metabolic and signaling pathways in the cell. Mitochondrial morphology is regulated by constant fusion fission events to maintain a functional mitochondrial network remodel response external stimuli. Although role of mitochondria later stages spermatogenesis has been investigated depth, dynamics regulating early germ cell behavior relatively less-well understood. We previously demonstrated required...
Migrating cells and growth cones extend lamellipodial filopodial protrusions that are required for outgrowth guidance. The mechanisms of cytoskeletal regulation underlie cell cone migration much interest to developmental biologists. Previous studies have shown the Arp2/3 complex UNC-115/abLIM act redundantly mediate lamellipodia filopodia formation axon pathfinding. While is known about Arp2/3, less regulators UNC-115/abLIM. Here we show Caenorhabditis elegans counterpart Receptor Activated...
Adult stem cells coordinate intrinsic and extrinsic, local systemic, cues to maintain the proper balance between self-renewal differentiation. However, precise mechanisms use integrate these signals remain elusive. Here, we show that Escargot (Esg), a member of Snail family transcription factors, regulates maintenance somatic cyst (CySCs) in Drosophila testis by attenuating activity pro-differentiation insulin receptor (InR) pathway. Esg positively expression an antagonist signaling, ImpL2,...
The Rac and Cdc42 GTPases as well the multiple GTP exchange factors that regulate their activity have been implicated in pathways drive actin cytoskeleton reorganization, but individual contributions of these molecules to cell migration remain unknown. Studies shown here examine roles CED-10/Rac, MIG-2/RhoG CDC-42 QL QR neuroblasts C. elegans. CED-10/Rac was found normally limit protrusion migration, whereas required for migration. also had redundant Q Surprisingly, only weak effects on We a...
During development, neuronal cells extend an axon toward their target destination in response to a cue form properly functioning nervous system. Rho proteins, Ras-related small GTPases that regulate cytoskeletal organization and dynamics, cell adhesion, motility, are known guidance. Despite extensive knowledge about canonical proteins (RhoA/Rac1/Cdc42), little is the Caenorhabditis elegans (C. elegans) atypical Cdc42-like family members CHW-1 CRP-1 regards pathfinding migration....
The Rho subfamily of small GTPases is critical for the regulation actin cytoskeleton in processes such as cell migration, axon extension and adhesion. Three major groups comprise this family: Rac, Cdc-42. Rac proteins have a key role protrusions (lamellipodia filopodia) during migration extension. In developing neurons, growth cones extend lamellipodia filopodia, which are composed meshwork bundles filaments, respectively. These aid migrating cone with guidance motility necessary its proper...
As the healthcare burden caused by an increasingly aging population rapidly rises, a pressing need exists for innovative geroscience research that can elucidate mechanisms and precipitate development of therapeutic interventions to support healthy aging. The Fifth Annual Midwest Aging Consortium Research symposium, held from April 28-30, 2024, was hosted Ohio State University in Columbus, featured presentations investigators across Midwestern United States. This report summarizes presented...
Abstract During development, neuronal cells extend an axon towards their target destination in response to a cue form properly functioning nervous system. Rho proteins, Ras-related small GTPases that regulate cytoskeletal organization and dynamics, cell adhesion, motility, are known guidance. Despite extensive knowledge about canonical proteins (RhoA/Rac1/Cdc42), little is the Caenorhabditis elegans ( C. ) atypical Cdc42-like family members CHW-1 CRP-1 regards pathfinding migration. chw-1...