A5074414177- Computational Drug Discovery Methods
- Complementary and Alternative Medicine Studies
- HIV/AIDS Research and Interventions
- Antibiotic Use and Resistance
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Ethnobotanical and Medicinal Plants Studies
- Global Maternal and Child Health
- Musculoskeletal Disorders and Rehabilitation
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmaceutical studies and practices
- HIV/AIDS Impact and Responses
- HIV-related health complications and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Drug Transport and Resistance Mechanisms
- Diverse Scientific Research Studies
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Parasites and Host Interactions
- Adolescent Sexual and Reproductive Health
- Hibiscus Plant Research Studies
- Psidium guajava Extracts and Applications
- Historical and modern epidemiology studies
University of Limpopo
2013-2024
University of KwaZulu-Natal
2015-2024
Acquired Immune Deficiency Syndrome is the most severe phase of Human Immunodeficiency Virus (HIV) infection. Recent studies have seen an effort to isolate phytochemicals from plants repress HIV, but less focused on effects these activities enzymes/transporters involved in metabolism drugs, which one aims this study and, examine antiviral activity compounds against HIV-1 protease enzyme using computational tools. Centre Awareness-Food Supplement (COA®-FS) herbal medicine, has been said...
Diabetes mellitus (DM) is a global health burden that characterized by the loss or dysfunction of pancreatic β-cells. In β-cells, endoplasmic reticulum (ER) stress fact life contributes to β-cell dysfunction. Despite recent advances in research, existing treatment approaches such as lifestyle modification and use conventional therapeutics could not prevent β-cells abrogate disease progression. Therefore, targeting ER consequent unfolded protein response (UPR) may be potential therapeutic...
Background The use of quality indicators in healthcare systems is one the factors that improve health services. However, for assessing human immunodeficiency virus and acquired syndrome (HIV AIDS) clinical care context low- middle-income countries are not defined. This study aims to assess compare pertinent practice utility these from perspective professionals (HCPs) specializing HIV AIDS Democratic Republic Congo (DRC) South Africa (RSA). Methods After a systematic review care, we conducted...
P-glycoprotein (ABCB1) and cytochrome P450 3A4 (CYP3A4) metabolize almost all known human immunodeficiency virus' protease inhibitor drugs (PIs). Over induction of these proteins' activities has been linked to rapid metabolism PIs which are then pumped out the circulatory system, eventually leading drug-resistance in HIV-positive patients. This study aims determine, with use computational tools, inhibitory potential four phytochemical compounds (PCs) (epigallocatechin gallate (EGCG),...
Background HIV-infected people may present with co-infections, comorbidities, and side effects associated antiretroviral therapy. This study explored the prevalence of comorbid health problems determined extent use traditional medicine for treatment comorbidities HIV infection effects. Methods A cross sectional study, using researcher-administered questionnaires, was carried out among patients in eight public sector healthcare facilities KwaZulu-Natal between April October 1024. Self-reports...
The roll out of antiretroviral therapy in the South African public health sector 2004 was preceded by politicisation HIV-infection which used to promote traditional medicine for management HIV/AIDS. One decade has passed since; however, questions remain on extent use traditional, complementary and alternative (TCAM) HIV-infected patients. This study therefore aimed at investigating prevalence (ATM), medicines (CAM) adult patients eThekwini UThukela Health Districts, Africa.A cross- sectional...
Background: The Beers Criteria were developed with the aim of improving safety medicines among older persons. While association between Beers' list potentially inappropriate (PIMs) and adverse drug reactions (ADRs) Caucasians is contentious, ability to predict ADRs persons in Africa remains unexplored. Objectives: This study aimed compare prevalence PIMs hospitalized Nigeria South Africa, determine 2015 American Geriatrics Society-Beers (AGS-Beers) ADRs. Methods: medical records aged ≥60...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a pneumonia-like disease with pattern of acute respiratory symptoms, currently remains significant public health concern causing tremendous human suffering. Although several approved vaccines exist, vaccine hesitancy, limited availability, high rate viral mutation, and the absence drugs account for persistence SARS-CoV-2 infections. The investigation possibly repurposing phytochemical compounds as therapeutic alternatives has...
The paper is based on a study which used primary and secondary sources to examine the influence of culture food habits in Tanzania Democratic Republic Congo.The revealed that impacted habits, through production, distribution, consumption. other factor considered was HIV/AIDS. As community knowledge-holders die AIDS, they take with them their local knowledge experiences. In times severe labour shortages owing people plant fewer crop varieties save time money. There should also be...
Many patients with human immunodeficiency virus infection use traditional, complementary, and alternative medicines other practices to combat the disease, some also using prescribed antiretroviral therapy provided by public health sector. This study aimed establish awareness of sector biomedical care providers on complementary HIV-infected who used highly active therapy, determine whether this was based seen or cases being reported them. Potential risks interactions between non-prescribed...
Abstract Essential oils are combinations of naturally occurring phytochemicals that, alone or in synergy with other compounds, can therapeutically attenuate disease-causing viral infections such as SARS-CoV-2, Ebola, and Marburg viruses. This study aimed to investigate the biosafety identification antiviral Spondias mombin (Linn) leaf crude extracts by GC–MS analysis. analysis showed that compound concentrations were dependent on polarity extracting solvent SMH (34), SMDCM (36), SMEA (12),...
Background: Schistosomiasis is the third most important Neglected Tropical Disease, with more than 4 million South Africans being infected. Cases of re-infection schistosomiasis after treated using modern medication has opened ways to seeking alternative treatment modalities medicinal plants. This study aims explore and understand way traditional healers diagnose schistosomiasis, types medicines they use treat it in communities a high prevalence infection, establish whether unavailability...
Background Praziquantel is the commonly used conventional treatment recommended for schistosomiasis in mainstream healthcare system. Although may be free facilities, many individuals resort to use of traditional medicine. This study aimed assess perceptions participants on availability and ascertain whether infected with concurrently African medicines this treatment. Methods A cross–sectional descriptive study, using face-to-face interviews, was conducted from January April 2023...
The main proteinase (Mpro), or 3CLpro, is a critical enzyme in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lifecycle and responsible for breaking down releasing vital functional viral proteins crucial virus development transmission. As catalytically active dimer, its dimerization interface has become an attractive target antiviral drug development. Recent research extensively investigated enzymatic activity of Mpro, focusing on role regulating replication complex...