A5017313233- Drug Transport and Resistance Mechanisms
- Ethnobotanical and Medicinal Plants Studies
- Drug Solubulity and Delivery Systems
- Complementary and Alternative Medicine Studies
- Advanced Drug Delivery Systems
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Tuberculosis Research and Epidemiology
- Gastrointestinal motility and disorders
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- African cultural and philosophical studies
- Global Health and Epidemiology
- Skin Protection and Aging
- Phytochemicals and Medicinal Plants
- Hydrogels: synthesis, properties, applications
- Traditional and Medicinal Uses of Annonaceae
- Contact Dermatitis and Allergies
- Global Health and Surgery
- Bee Products Chemical Analysis
- Endoplasmic Reticulum Stress and Disease
- Pharmacogenetics and Drug Metabolism
- Cannabis and Cannabinoid Research
- African Botany and Ecology Studies
Tshwane University of Technology
2010-2024
Diabetes mellitus (DM) is a global health burden that characterized by the loss or dysfunction of pancreatic β-cells. In β-cells, endoplasmic reticulum (ER) stress fact life contributes to β-cell dysfunction. Despite recent advances in research, existing treatment approaches such as lifestyle modification and use conventional therapeutics could not prevent β-cells abrogate disease progression. Therefore, targeting ER consequent unfolded protein response (UPR) may be potential therapeutic...
Background: Plants are important sources of medicines. Herbal medicines in Lesotho exposed to excessive exploitation and habitat destruction. Comprehensive information promote proper use conservation these herbal is lacking. This study described the uses medicinal plants with comparative reference between practice literature, highlighting ethno-medicinal status plants. Additionally, established a repository monograph for Lesotho.Materials Methods: Medicinal plant samples on their were...
Context: Dietary botanicals are often consumed together with allopathic medicines, which may give rise to pharmacokinetic interactions. In vitro intestinal models useful identify botanical-drug interactions, but they exhibit different expressions of transporters or enzymes.Objective: To compare the effects selected dietary botanical extracts on cimetidine transport across two in models.Materials and Methods: Bi-directional was measured Caco-2 cell monolayers excised porcine jejunum tissue...
Background: Plants are important sources of medicines. Herbal medicines in Lesotho exposed to excessive exploitation and habitat
 destruction. Comprehensive information promote proper use conservation these herbal is lacking. This study described the
 uses medicinal plants with comparative reference between practice the literature, highlighting ethno-medicinal
 status plants. Additionally, established a repository monograph for in
 Lesotho.
 Materials Methods:...
Background and objectivesInfection prevention control is a set of practices, protocols, procedures that are put in place to prevent infections associated with health care service provision settings.It an element quality safety delivery; worker occupational practices; medical waste management; also concerned clinical public surveillance action.Healthcare facilities ideal settings for the transmission patients (who more susceptible), healthcare workers, their families communities.Healthcare...
the use of skin lightening products (SLPs) by women is poorly documented in Africa, with statistics from some countries entirely missing. This study assessed knowledge, perceptions, practices and factors associated health risk awareness African Basotho towards SLPs.this was a questionnaire-based cross-sectional based on convenience sampling females secondary/high schools, universities, factories business offices Maseru City, Lesotho. Analysis differences knowledge (adequate ≥50% score),...
Edible wild plants were investigated as potential sources of antioxidants and prebiotics to benefit human health. Antioxidant activity, ascorbic acid total dietary fibre contents determined in edible from Lesotho, Swaziland South Africa. Pure probiotic strains Bifidobacterium animalis subsp. (ATCC 25527), Lactobacillus rhamnosus (TUTBFD) acidophilus 314) cultured broth containing plant extracts assess their prebiotic activity. Cyperus esculantus had the highest arscobic content 603±64.1...
Matrix-type drug delivery systems were prepared by moulding and drying cross-linked chitosan gels in 24-well plates they evaluated terms of their physical properties, content, surface morphology swelling. Furthermore, the vitro release profiles subjected to kinetic modelling at two different pH values. In general, moulded matrix showed statistically significantly slower compared immediate tablets as measured mean dissolution time. Drug from with tripolyphosphate was pH-dependent can be seen...
Tuberculosis is a global public health problem. Lesotho, sub-Saharan country with high HIV and tuberculosis burden, launched the Three I’s programme of World Health Organization in 2013. However, outcomes this intervention are scarcely known. This study evaluated profile diagnostic techniques used, treatment associated factors across baseline period (2010–2012) after launch (2013–2015) based on retrospective cohort review patient records at major clinic Maseru, Lesotho. In total, 812 cases...
Tuberculosis is a global public health problem. Lesotho, sub-Saharan country with high HIV and tuberculosis burden, launched the Three I’s programme of World Health Organization in 2013. However, outcomes this intervention are scarcely known. This study evaluated profile diagnostic techniques used, treatment associated factors across baseline period (2010–2012) after launch (2013–2015) based on retrospective cohort review patient records at major clinic Maseru, Lesotho. In total, 812 cases...
Plant materials in the form of fruit, vegetables or herbal medicines are often taken conjunction with allopathic medicines. Pharmacodynamic and/or pharmacokinetic interactions may occur between phytoconstituents and co-administered drug [1]. Pharmacokinetic include interferences delivery distribution by means altered absorption, metabolism, elimination [2]. This work reports on effects extracts from traditional medicinal plants (Hypoxis hemerocallidea Sutherlandia frutescens), fruit...
P-glycoprotein (P-gp) is a membrane-bound transporter protein, which causes multidrug-resistance in tumour cells [1]. It also localized the apical membrane of normal intestinal epithelial [2] where it actively pumps substrates from within cell back into lumen with consequent reduction their bioavailability [3]. Many drugs, herbs and food substances may inhibit or induce P-gp, consequently influence absorption co-administered drugs [4]. The aim this study was to investigate effect selected...