A5076549368- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- EEG and Brain-Computer Interfaces
- Cancer Immunotherapy and Biomarkers
- Obsessive-Compulsive Spectrum Disorders
- Neonatal and fetal brain pathology
- Language Development and Disorders
- Autoimmune Neurological Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Behavioral and Psychological Studies
- Second Language Learning and Teaching
- Advanced Text Analysis Techniques
- Immune cells in cancer
- Hypothalamic control of reproductive hormones
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Vestibular and auditory disorders
- Pharmacological Receptor Mechanisms and Effects
- Fetal and Pediatric Neurological Disorders
- International Student and Expatriate Challenges
- Face Recognition and Perception
Harvard University
2022-2025
Harvard University Press
2024
University of California, Los Angeles
2020-2024
Neurobehavioral Systems
2021-2024
Lemuel Shattuck Hospital
2022
University of California, Berkeley
2019-2021
Brain Mapping Foundation
2020
University of Denver
2020
Columbia University
2020
Yamaguchi University
2018-2019
Autoimmunity to membrane proteins in the central nervous system has been increasingly recognized as a cause of neuropsychiatric disease. A key recent development was discovery autoantibodies N-methyl-d-aspartate (NMDA) receptors some cases encephalitis, characterized by cognitive changes, memory loss, and seizures that could lead long-term morbidity or mortality. Treatment approaches experimental studies have largely focused on pathogenic role these autoantibodies. Passive antibody transfer...
Abstract Sensory over-responsivity (SOR), extreme sensitivity to or avoidance of sensory stimuli (e.g., scratchy fabrics, loud sounds), is a highly prevalent and impairing feature neurodevelopmental disorders such as autism spectrum (ASD), anxiety, ADHD. Previous studies have found overactive brain responses reduced modulation thalamocortical connectivity in response mildly aversive stimulation ASD. These findings suggest altered thalamic gating which could be associated with an...
Prior studies have demonstrated that infants and toddlers who later go on to develop autism spectrum disorder (ASD) show atypical functional connectivity as well altered neural processing of language other auditory stimuli, but the timeline underlying emergence these developmental trajectories is still unclear. Here we used resting-state fMRI (rsfMRI) during natural sleep examine longitudinal development in language-related networks from 1.5 9 months age. We found underlie integration...
Abstract Background Language difficulties are common in autism spectrum disorder (ASD), a neurodevelopmental condition characterized by impairments social communication as well restricted and repetitive behaviors. Amongst infant siblings of children with an ASD diagnosis – who at higher likelihood for developing high proportion also show delays language acquisition. Methods In this study, we used functional magnetic resonance imaging (fMRI) to examine differences processing 9-month-old...
In humans, nonhuman primates, and rodents, the frontal cortices exhibit grey matter thinning dendritic spine pruning that extends into adolescence. This maturation is believed to support higher cognition but may also confer psychiatric vulnerability during Currently, little known about how specific cell types in cortex mature or whether puberty plays a role of some not others. Here, we used mice characterize spatial topography adolescent development cross-corticostriatal (cSTR) neurons...
Despite growing evidence implicating thalamic functional connectivity atypicalities in autism spectrum disorder (ASD), it remains unclear how such alterations emerge early human development. Because the thalamus plays a critical role sensory processing and neocortical organization life, its with other cortical regions could be key for studying onset of core ASD symptoms. Here, we investigated emerging thalamocortical infants at high (HL) typical (TL) familial likelihood late infancy. We...
The cerebellum has been consistently shown to be atypical in autism spectrum disorder (ASD). However, despite its known role sensorimotor function, there is limited research on association with sensory over-responsivity (SOR), a common and impairing feature of ASD. Thus, this study sought examine functional connectivity the ASD compared typically developing (TD) youth investigate whether cerebellar associated SOR. Resting-state was examined 54 43 TD aged 8-18 years. Using seed-based...
While the cerebellum is traditionally known for its role in sensorimotor control, emerging research shows that particular subregions, such as right Crus I (RCrusI), support language and social processing. Indeed, cerebellar atypicalities are commonly reported autism spectrum disorder (ASD), a neurodevelopmental characterized by socio-communicative impairments. However, cerebellum's contribution to early development remains virtually unknown.Here, we functional connectivity within...
Abstract The biological mechanisms underlying the greater prevalence of autism spectrum disorder in males than females remain poorly understood. One hypothesis posits that this female protective effect arises from genetic load for differentially impacting male and brains. To test hypothesis, we investigated impact cumulative risk on functional brain connectivity a balanced sample boys girls with typically developing (127 youth, ages 8–17). Brain analyses focused salience network, core...
Abstract Background Social interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth autism spectrum disorders (ASD) who commonly experience over-responsivity (SOR) addition to social challenges. However, the relationship between SOR and difficulties still poorly understood thus rarely addressed interventions. study investigated effect of auditory distracters on neural processing emotion identification ASD effects increasing...
Background Language difficulties are common in autism spectrum disorder (ASD), a neurodevelopmental condition characterized by impairments social communication as well restricted and repetitive behaviors. Amongst infant siblings of children with an ASD diagnosis - who at higher likelihood for developing high proportion also show delays language acquisition. Methods In this study, we used functional magnetic resonance imaging (fMRI) to examine atypicalities associated processing 9-month-old...
Abstract Autoimmunity to membrane proteins in the central nervous system has been increasingly recognized as a cause of neuropsychiatric disease. A key recent development was discovery antibodies NMDA receptors limbic encephalitis, characterized by cognitive changes, memory loss, seizures and sometimes long-term morbidity or mortality. Treatment approaches experimental studies have largely focused on pathogenic role these autoantibodies. Passive antibody transfer mice provided useful...
In humans, nonhuman primates, and rodents, the frontal cortices exhibit grey matter thinning dendritic spine pruning that extends late into adolescence. This protracted maturation is believed to support higher cognition but may also confer psychiatric vulnerability during Currently, little known about how different cell types in cortex mature or whether puberty plays a role. Here, we used mice characterize spatial topography adolescent development of cross-corticostriatal (cSTR) neurons...
本論文では，テキストマイニング技術を用いて，株主招集通知の情報をデータベースに格納する業務の効率化を実現するための応用システムの研究について述べる．効率化したい業務とは，株主招集通知に記載されている議案の開始ページを予測し，その開始ページにおける議案の議案タイトルと議案内容を分類する業務である．本研究では，これらの業務を株主招集通知のテキスト情報を用いて自動的に行うシステムを開発し，実際に運用している．本研究によって実装したシステムと従来の人手による作業の比較実験の結果，作業時間は 1/10 程度に短縮された．議案分類の手法としては，学習データから抽出した特徴語の重みを用いた分類，多層ニューラルネットワーク（深層学習）を用いた分類，抽出した議案タイトルを用いた分類の三手法を用いた．さらに，各手法の評価を行い，各手法の議案ごとの有効性を確認した．
Abstract BackgroundSocial interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth autism spectrum disorders (ASD) who commonly experience over-responsivity (SOR) addition to social impairment. However, the relationship between these symptoms still poorly understood and thus rarely addressed interventions. study investigated effect of auditory distracters on neural processing emotion identification ASD effects increasing...
Abstract Background: Social interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth autism spectrum disorders (ASD) who commonly experience over-responsivity (SOR) addition to social impairment. However, the relationship between these symptoms still poorly understood and thus rarely addressed interventions. study investigated effect of auditory distracters on neural processing emotion identification ASD effects increasing...