A5067357551- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Muscle and Compartmental Disorders
- Tissue Engineering and Regenerative Medicine
- TGF-β signaling in diseases
- NF-κB Signaling Pathways
- Medical research and treatments
- Mesenchymal stem cell research
- Shoulder Injury and Treatment
- Medical and Biological Ozone Research
Universitat Pompeu Fabra
2020-2023
Institute for Research in Biomedicine
2018
Institut d'Investigacions Biomèdiques de Barcelona
2017
TGIF1 is a multifunctional protein that represses TGF-β-activated transcription by interacting with Smad2-Smad4 complexes. We found the complex structure of TGIF1-HD bound to TGACA motif revealed combined binding mode involves HD core and major groove, on one hand, amino-terminal (N-term) arm minor groove DNA, other. also show interacts MH1 domain Smad proteins, thereby indicating protein-binding domain. Moreover, formation HD-MH1 partially hinders DNA-binding site complex, preventing...
Abstract Multisubunit Tethering Complexes (MTCs) are a set of conserved protein complexes that tether vesicles at the acceptor membrane. Interactions with other components trafficking machinery regulate MTCs through mechanisms partially understood. Here, we systematically investigate interactome regulates MTCs. We report P4‐ATPases, family lipid flippases, interact participate in anterograde and retrograde transport Golgi, such as TRAPPIII. use P4‐ATPase Drs2 paradigm to mechanism biological...
Epithelial to mesenchymal transition (EMT) has emerged as a key process in the development of renal fibrosis. In fact, EMT-derived fibroblasts contribute progression chronic disease. addition, anti-inflammatory M2 macrophages have exhibited great influence on However, because high impact that inputs different environmental cytokines their phenotype, can easily lose this property. We aim known if microencapsulated M2-inducing alginate matrices could preserve macrophage phenotype and thus...
Abstract Multisubunit Tethering Complexes (MTCs) are a set of conserved protein complexes that tether transported vesicles at the acceptor membrane. Interactions with other components trafficking machinery regulate MTCs through mechanisms just partially understood. Here we systematically investigate interactome regulates function MTCs. We found P4-ATPases, family lipid transporters involved in biogenesis vesicles, interact participate anterograde and retrograde transport Golgi, such as...