A5010116471- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
- Antibiotic Use and Resistance
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Multicomponent Synthesis of Heterocycles
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
- Medical Education and Admissions
- Essential Oils and Antimicrobial Activity
- Dental Research and COVID-19
- Obesity, Physical Activity, Diet
- Healthcare and Environmental Waste Management
- Parkinson's Disease Mechanisms and Treatments
- Heart Failure Treatment and Management
- Nigella sativa pharmacological applications
- Sodium Intake and Health
- PARP inhibition in cancer therapy
- Musculoskeletal pain and rehabilitation
- Municipal Solid Waste Management
- Cancer Mechanisms and Therapy
- Patient Satisfaction in Healthcare
- Infection Control and Ventilation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and biological activity
King Khalid University
2020-2024
A novel combination of antibiotic, ciprofloxacin (CIP) with herbal counterpart naringin (NAR) was encapsulated by an oleic acid lipid core and carboxymethyl chitosan (CM–CS)/Alginate (AG) nanoparticle composite (CIP + NAR–CM–CS/AG–NPs) for improved antimicrobial efficacy antibiotic. Herein, this study explored the design preparation a system that enables to deliver both CIP NAR from CM–CS/AG nanoparticles using nonsolvent ionic gelation technique. The (NPs) were fabricated long-acting...
Background: Basidiobolomycosis is a fungal infection caused by Basidiobolus ranarum . It primarily located in the tropical areas. commonly affecting gastrointestinal tract and rarely presents with systemic affection. Patients Methods: The records of fifteen patients, including pediatrics, from various geographic regions (western southern Kingdom Saudi Arabia) who were diagnosed basidiobolomycosis two tertiary hospitals over last fourteen consecutive years January 2010 to February 2023...
Lung carcinoma is the leading cause of cancer-related mortalities worldwide, and present therapeutical interventions are not successful enough to treat this disease in many cases. Recent years have witnessed a surge exploring natural compounds for their antiproliferative efficacy expedite characterization novel anticancer chemotherapeutics. Swertia chirayita valued medicinal herb possess intrinsic pharmaceutical potential. However, elucidation its effects at molecular levels remains unclear...
Adenium obesum commonly known as "desert rose" belongs to the family Apopcynaceae and has previously been reported for its anti-influenza, antimicrobial, cytotoxic efficacies well-known their ethno-medicinal applications. In present study, ethanolic extracts of A. (AOE) were analyzed by gas chromatography-mass spectrometry (GC-MS) identify important phytochemical compounds. The GC-MS analysis AOE detected presence 26 This plant is traditionally used treatment various diseases. this report,...
Poor waste management of unused or expired medications jeopardizes healthcare staff, employees who oversee medical waste, patients and their families, the neighboring population, environmental contamination. In addition, inappropriate treatment disposal that leads to. exerts an intolerable burden on economy health care facilities. Currently, there is a lack data in community settings regarding adequate methods medication Saudi Arabia.The current study aimed to evaluate knowledge awareness...
Background The COVID-19 pandemic had an enormous impact on people’s quality of life worldwide. Appropriate use facemasks is important checkpoint in containing the spread infection, which was believed to provide desired level protection and preserve community. Given relative novelty facemask general population, it imperative prioritize promotion appropriate utilization identify factors that may contribute poor adherence. Aim This study assessed determined among public. Methods A...
In this study, choline chloride/urea was used as a green deep eutectic solvent in the three-component reaction of hydrazine/phenylhydrazine, malononitrile, and aromatic aldehydes for synthesizing pyrazole derivatives, four-component methyl/ethyl acetoacetate, pyrano[2,3-c]pyrazole derivatives. Elemental analysis, 1 H, 13 C NMR spectroscopy were to confirm structure synthesized pyrano[2,3-c] The antimicrobial effects derivatives investigated. tests, instructions from clinical laboratory...
Students face more challenging conditions as they move forward with their education. As a result of these negative circumstances are vulnerable to mental disorders like anxiety and depression. Thus, the study's goal was determine symptoms depression among King Khalid University students in Saudi Arabia's southern region. A descriptive online institution-based cross-sectional survey design conducted for period 3 months from 20.12.2023 29.02.2024 assess university students. This study utilized...
Background Knee osteoarthritis (KOA) is one of the most common conditions resulting in disability, particularly elderly population. Osteoarthritis (OA) articular disease and leading cause chronic disability developed world. Objective This study was carried out to evaluate knee pain Asir region Saudi Arabia. An analytical cross-sectional survey design adopted from April 2023 August assess adult population using an anonymous online questionnaire. Results Of 1234, 332 were men (26.90) 902 women...
Limited data are available on factors that associated with passing rates for the Saudi Pharmacist Licensure Examination (SPLE). The aim of this study is to investigate student characteristics and academic performance may predict their success SPLE. This was a single-institution retrospective cohort study, which included pharmacy graduates from 2019 2021. Demographic, academic, SPLE were collected each graduate. Binary logistic regression used explore association between potential predictors...
Poly [adenosine diphosphate (ADP)-ribose] polymerases (PARPs) are members of a family 17 enzymes that performs several fundamental cellular processes. Aberrant activity (mutation) in PARP12 has been linked to various diseases including inflammation, cardiovascular disease, and cancer. Herein, large library compounds (ZINC-FDA database) screened virtually identify potential inhibitor(s). The best were selected on the basis binding affinity scores poses. Molecular dynamics (MD) simulation free...
Migraine is a disabling disease that poses significant societal burden. major cause of disability. the eighth leading disease-causing disability in population.
Minichromosome maintenance complex component 7 (MCM7) is involved in replicative licensing and the synthesis of DNA, its overexpression a fascinating biomarker for various cancer types. There currently no effective agent that can prevent development caused by MCM7 protein. However, on molecular level, inhibiting lowers cancer-related cellular growth. With this purpose, study screened 452 biogenic compounds extracted from UEFS Natural Products dataset against MCM protein using silico art...
Cervical cancer (CCa) is the second most frequent carcinoma in females and human papilloma virus (HPV) oncoproteins are regarded as one of critical etiological agent. Despite recent advances screening management CCa, still it remains deadliest advanced metastatic stages mostly incurable. This urges for development newer therapeutic interventions. The current was aimed to investigate antiproliferative apoptotic potential glycyrrhizin (Gly) against HPV16+ CaSki CCa cells. Our findings...
Despite the availability of human papillomavirus (HPV) vaccines and screening facilities at various health centers in Saudi Arabia, annual death rate due to cervical cancer is high. Therefore, knowledge awareness are essential for self-care educating others, particularly among healthcare students. The present descriptive, cross-sectional study explored female pharmacy students' knowledge, attitudes, practices related cancer. A total 140 students participated survey. survey was conducted...
Background Resistance to antibiotics causes negative impact on health of the patients. Antibiotic resistance is major global concern that has be nullified for better outcome. The knowledge very essential students who undertake pharmacy and science courses. Hence a study was aimed assess level knowledge, attitude, perception practice usage among King Khalid University, KSA. Materials methods A prospective online questionnaire based survey carried out about attitude using 5-point "Likert...
As the number of unemployment among pharmacy graduates increases, Saudi Ministry Labor implemented extra measures to facilitate their training and hiring by private sectors. Nevertheless, there is a paucity data regarding graduates' work readiness (WR). Hence, we aim assess WR identify predicting factors associated with in Arabia.A 46-item self-reported pre-validated anonymous scale (WRS) survey 5-point Likert was administered senior students using Qualtrics XM® tool over month May 2020. The...
Background Antimicrobials save millions of lives annually from dying because bacterial infections, but the rapid emergence antimicrobial resistance (AMR) becomes a global threat. The Saudi Ministry Health (MOH) has taken containment measures to limit misuse antimicrobials via implementing restrictions on dispensing without prescriptions. Hence, we aim evaluate impact regulating sales and identify challenges that pharmacists are facing prevent self-medication with agents. Materials Methods A...
Mycobacterium tuberculosis (Mtb) is a deadly (TB)-causing pathogen. The proteasome vital to the survival of Mtb and therefore validated as potential target for anti-TB therapy. resistance existing antibacterial agents has enhanced drastically, becoming worldwide health issue. Therefore, new therapeutic need be developed that can overcome complications TB. With this purpose, in present study, 224,205 natural compounds from ZINC database have been screened against catalytic site by...
Abstract Objectives Although depression symptoms are common among patients with Parkinson's disease (PD), the medical literature still reports underrecognition of in PD. Our main objective is to examine trend recognition during first year PD diagnosis using large population data. Methods We conducted a population‐based study residents Wales, Secure Anonymized Information Linkage (SAIL) Databank. included newly diagnosed aged 40 years or older between 2000 and 2015. Depression antidepressants...
Non-small-cell lung cancer (NSCLC) mortality and new case rates are both on the rise. Most patients have fewer treatment options accessible due to side effects from drugs emergence of drug resistance. Bedaquiline (BQ), a licensed by FDA treat tuberculosis (TB), has demonstrated highly effective anti-cancer properties in past. However, it is difficult transport biological barriers because their limited solubility water. Our study developed UPLC method whose calibration curves showed linearity...
In this study, Co 3 O 4 nanoparticles were used as nanocatalyst for two different series of nitrogen-containing heterocyclic compounds, including pyrrole (Pyo) derivatives and pyrano [2, 3-c]pyrazole (Pya[2, 3-c]Pyz) derivatives. the synthesis derivatives, using 15 mol% 10 catalyst Pyo Pya[2, 3-c]Pyz respectively, an efficiency between 83% 96%, observed. addition, novel Pya[2,3-c]Pyz synthesized their structures confirmed. general, advantages cobalt compared to previous reports include new...