A5000009817- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Natural Antidiabetic Agents Studies
- Neonatal Respiratory Health Research
- Metabolomics and Mass Spectrometry Studies
- Congenital Diaphragmatic Hernia Studies
- Advanced Drug Delivery Systems
- Computational Drug Discovery Methods
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Plant-based Medicinal Research
- Diverse Scientific Research Studies
- Pain Mechanisms and Treatments
- Alcohol Consumption and Health Effects
- Congenital Heart Disease Studies
- Nanocomposite Films for Food Packaging
- Algal biology and biofuel production
- Nanoplatforms for cancer theranostics
- Pharmacological Effects and Toxicity Studies
- Advanced Nanomaterials in Catalysis
- Ginger and Zingiberaceae research
- Advancements in Transdermal Drug Delivery
- Long-Term Effects of COVID-19
National Guard Health Affairs
2024-2025
King Abdulaziz Medical City
2024-2025
Umm al-Qura University
2021-2024
A novel combination of antibiotic, ciprofloxacin (CIP) with herbal counterpart naringin (NAR) was encapsulated by an oleic acid lipid core and carboxymethyl chitosan (CM–CS)/Alginate (AG) nanoparticle composite (CIP + NAR–CM–CS/AG–NPs) for improved antimicrobial efficacy antibiotic. Herein, this study explored the design preparation a system that enables to deliver both CIP NAR from CM–CS/AG nanoparticles using nonsolvent ionic gelation technique. The (NPs) were fabricated long-acting...
Background: Liver cancer is the sixth most prevalent form of and second major cause cancer-associated mortalities worldwide. Cancer nanotechnology has ability to fundamentally alter treatment, diagnosis, detection. Objective: In this study, we explained development graphene oxide/polyethylene glycol/folic acid/brucine nanocomposites (GO/PEG/Bru-FA NCs) evaluated their antimicrobial anticancer effect on liver HepG2 cells. Methodology: The GO/PEG/Bru-FA NCs were prepared using co-precipitation...
Aims This study aims to evaluate the association between Oxygenation Index (OI) and Oxygen Saturation (OSI) in extremely preterm infants. In addition, seeks determine predictive value of these indices for mortality first 7 days Bronchopulmonary Dysplasia (BPD) at 36 weeks postmenstrual age (PMA). Methods is a prospective observational conducted King Abdulaziz Medical City, Riyadh October 2023 May 2024, involving infants with clinical ventilator data collected during life. The capabilities OI...
High Frequency Oscillatory Ventilation (HFOV) combined with volume guarantee (HFOV-VG) represents an innovative ventilation mode designed for managing respiratory failure in neonates. This study aimed to assess the stability of tidal (VThf) extremely preterm infants ventilated on HFOV VG during first 48 h life. Additional objectives included examining correlations between VThf, Diffusion Coefficient Carbon Dioxide (DCO2) and key markers. retrospective, single-center 22 treated HFOV-VG as...
Gaining knowledge about the differences in substance P (SP) and neurokinin 1 receptor (NK1R) levels between cardiac hypertensive patients may help clarify how these neuropeptides could be involved pathophysiology of cardiovascular disorders. This study aimed to investigate SP NK1R individuals diagnosed with hypertension conditions. Participants were chosen from a pool (n=30) (n=35) addition control group (n=12). Each participant was asked for their informed permission before any demographic...
Abstract Nanomedicine is the application of nanomaterials and nanotechnology to development novel pharmaceuticals drug delivery mechanisms. The present study synthesized a functionalized nanocomposite (NC) containing graphene oxide (GO), chitosan (Ch), manganese (Mn), folic acid (FA), brucine. anticancer properties GO/Mn/Ch/FA-Brucine NCs were evaluated against liver cancer cells. characterized using several characterization techniques. growth HepG2 Hep3B cells was analyzed...
Globally, dengue (DENV) fever has appeared as the most widespread vector-borne disease, affecting more than 100 million individuals annually. No approved anti-DENV therapy or preventive vaccine is available yet. DENV NS3 protein associated with protease activity and essential for viral replication process within host cell. NS2B linked a cofactor. Hence, NS3/NS2B potential druggable target developing inhibitors against virus. In present study, dataset of
Background and Aims: Tobacco smoking has a significant role in health deterioration worldwide. The study was conducted to estimate the prevalence awareness of among young Makkah people. Methods: A cross-sectional tobacco smoking’s prevalence, characteristics, perception, using GATS standardized questionnaire tool. Results: sample size 410, males 22.92% (n = 94), for fe¬males 14.39% 59). gender difference is (χ2 93.657, p < 0.001). Most are new users have used it less than one year with...
In this study, cobalt neurotoxicity was investigated in human astrocytoma and neuroblastoma (SH-SY5Y) cells using proliferation assays coupled with LC-MS-based metabolomics transcriptomics techniques. Cells were treated a range of concentrations between 0 200 µM. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed cytotoxicity decreased cell metabolism dose time-dependent manner observed by analysis, both lines. Metabolomic analysis also several altered...
Mephedrone is an illegal drug that used recreationally. Few studies have been conducted to investigate the mechanisms by which mephedrone harming cells. In this research, we investigated effect of using toxicology coupled with LC-MS/MS based metabolomics in two CNS derived cell lines. Methods assessment such as neutral red (NR) assay, dimethylthiazolyl diphenyltetrazolium bromide (MTT), lactose dehydrogenase (LDH) measurement, and morphology were performed identify on viability best...
Objective To explore the relationship between Oxygenation Index (OI) and Oxygen Saturation (OSI) among infants with Congenital Diaphragmatic Hernia (CDH), both within first 24 h after birth in extended observations those who survived until their surgical intervention. Methods Seven- years retrospective review of CDH cases at a single Level III neonatal intensive care unit. The correlations various combinations OI-OSI pairs were assessed using Spearman's rho Correlation Coefficient....
Many children were suffering from neurological problems. One of these problems is epilepsy, which causes seizures. Children with seizures managed different drugs. A drug like phenobarbital used mainly for epilepsy. This study aimed to assess the awareness parents about side effects and management epileptic children, describe clinical presentation epilepsy knowledge children. descriptive cross-sectional was conducted among diagnosed Online questionnaire survey distributed total 200 included....
The battle against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) associated coronavirus disease 2019 (COVID-19) is continued worldwide by administering firsttime emergency authorized novel mRNA-based and conventional vector-antigen-based anti- COVID-19 vaccines to prevent further transmission of the virus as well reduce complications infection in infected individuals. However; emergence numerous SARS-CoV-2 variants concern, identification certain breakthrough reinfection cases...
In this study we have formulated nanocomposite using graphene oxide, chitosan and folic acid as a nanocarrier loaded with phytochemical d-Pinitol subjected to spectroscopic microscopic analysis assess the shape, size structure. Nanocomposite was further cytotoxic against hepatoma HepG-2 cells non-malignant Vero MTT assay. The generation of ROS, disruption mitochondrial membrane permeability induction cell death corresponding fluorescent staining. Finally apoptotic proteins Bax, Bcl2 caspases...