A5090956355- Bioactive Compounds and Antitumor Agents
- Garlic and Onion Studies
- Essential Oils and Antimicrobial Activity
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Andrographolide Research and Applications
- Natural product bioactivities and synthesis
- Cholesterol and Lipid Metabolism
- Phytochemistry and biological activities of Ficus species
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects of Natural Compounds
- Food Allergy and Anaphylaxis Research
- Nanoparticles: synthesis and applications
- Protein Tyrosine Phosphatases
- Fungal Plant Pathogen Control
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Plant biochemistry and biosynthesis
- Phytochemical compounds biological activities
- Pharmacological Effects of Medicinal Plants
- Hedgehog Signaling Pathway Studies
- Curcumin's Biomedical Applications
- SARS-CoV-2 detection and testing
- Ethnobotanical and Medicinal Plants Studies
Integral University
2016-2025
Jamia Millia Islamia
2014-2021
Hadassah Medical Center
2021
Hebrew University of Jerusalem
2020
NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital
2015
Freeman Hospital
2013
Sarojini Naidu Medical College
2008
Indian Institute of Technology Kharagpur
2004
Johns Hopkins University
1994
Pooling multiple swab samples before RNA extraction and real-time reverse transcription polymerase chain reaction (RT-PCR) analysis has been proposed as a strategy to reduce costs increase throughput of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests. However, reports on practical large-scale group testing for SARS-CoV-2 have scant. Key open questions concern reduced sensitivity due sample dilution, the rate false positives, actual efficiency (number tests saved by...
Andrographolide, a diterpenoid lactone and major constituent of Andrographis paniculata Nees, exhibits remarkable anticancer activity. However, the effect andrographolide on colon cancer has not been completely elucidated yet. Thus, we investigated chemopreventive potential in HT-29 cells. The cytotoxic cells was determined by MTT assay, trypan blue exclusion colony formation morphological analysis; apoptotic property DAPI Hoechst staining, FITC-Annexin V DNA fragmentation assay caspase-3...
Carvacrol, a major monoterpenoid phenol from Origanum and Thymus species, has been shown to exhibit antiproliferative anticancer properties in few recent studies. Nevertheless, detailed mechanism of the action this compound prostate cancer not elucidated yet. Therefore, current study, we examined activity carvacrol against human cells. It was found that treatment DU145 cells with decreased cell viability concentration time-dependent manner. The leads induction apoptosis as confirmed by...
Several studies have revealed that abnormal activation of Notch signaling is closely related with the development and progression prostate cancer. Although there are numerous therapeutic strategies, a more effective modality least side effects urgently required for treatment Carvacrol monoterpenoid phenol majorly present in essential oils Lamiaceae family plants. Many previous reports shown various biological activities carvacrol like antioxidant, antiinflammatory anticancer properties....
Diabetes mellitus is a multifactorial disease that affects both developing and developed countries major public health concern. Many synthetic drugs are available in the market, which counteracts associated pathologies. However, due to propensity of side effects, there an unmet need for investigation safe effective drugs. This research aims find novel phytoconstituent having diminished action on blood glucose levels with least effects. Shikonin naturally occurring naphthoquinone dying...
Cervical cancer is the fourth most common among women worldwide and a major cause of morbidity mortality. High-risk Human Papilloma Virus (mostly type 16 & 18) infection primary risk factor for development cervical carcinoma. The quest strong, safe cost effective natural antiproliferative agents that could reduce have been focussed now day. Recently, glycyrrhizin, triterpene glycoside (saponin) from licorice (Glycyrrhiza glabra Linn.), has shown to exhibit potent anticancer properties in few...
Background: The carcinogenesis of the uterine cervix is predominantly initiated with consistent infection Human Papilloma Virus (HPV). Owing to side effects standard chemotherapeutics in treatment recurrent and metastatic cervical cancer, there a need for better effective modality. In this lieu concern, natural compounds have proven their worthwhile potential against various carcinomas. Carvacrol phenolic monoterpenoid several reports suggested its different biological properties including...
The potential of oxidized-LDL (Ox-LDL) to elicit inflammatory responses in macrophages leading the atherosclerosis (AS) progression is well known. Since proprotein convertase subtilisin/Kexin-9 (PCSK-9), posttranslational regulator LDL-receptor, associated with elevated LDL circulation, present report was aimed uncover ameliorative effects Ginkgolide B, a terpenic lactone from Ginkgo biloba , against Ox-LDL-induced alterations cholesterol metabolism HUVECs. Consequently, our results...
Growing emphasis on exploring the antiproliferative potential of natural compounds has gathered momentum for formulation anticancer drugs. In present study, and apoptotic glycyrrhizin (GLY) was studied HPV– C33A cervical cancer (CCa) cells. Our results indicated that GLY exerted effects in cells by inducing significant cytotoxicity. Treatment with substantially increases apoptosis a dose-dependent manner via disrupting mitochondrial membrane potential. induced activation capsase-9 (intrinsic...
This study reports the therapeutic effectiveness of doxorubicin-conjugated zinc oxide nanoparticles against lung cancer cell line. The (ZnONPs) were first synthesised using a fungus, isolated from air with an extraordinary capability to survive in very high concentrations salt. Molecular analysis based on 18S rRNA gene sequencing led its identification as Aspergillus niger NCBI accession no. OL636020. fungus was found produce ZnONPs via reduction ions sulphate. characterised by various...
The current study was undertaken to delineate the protective effect of Ginkgolide B, a phyto‐constituent from Ginkgo biloba , on oxidized (ox)‐LDL‐induced endothelial dysfunction via targeting Lectin‐like ox‐LDL‐receptor‐1 (LOX‐1), NADPH oxidase 4 (NOX‐4), and other inflammatory proteins. Our results have shown that B downregulated expression LOX‐1 in ox‐LDL‐treated human umbilical vein cells (HUVECs) RAW246.7 murine macrophages which ultimately resulted decreased cholesterol deposits HUVECs...
Lung carcinoma is the leading cause of cancer-related mortalities worldwide, and present therapeutical interventions are not successful enough to treat this disease in many cases. Recent years have witnessed a surge exploring natural compounds for their antiproliferative efficacy expedite characterization novel anticancer chemotherapeutics. Swertia chirayita valued medicinal herb possess intrinsic pharmaceutical potential. However, elucidation its effects at molecular levels remains unclear...
Diabetes is a complicated multifactorial disorder in which the patient generally observes polyphagia, polydipsia, and polyuria due to uncontrolled growth blood sugar levels. For its management, pharmaceutical industry working day night find better drug with no or least toxicity. That's why nowadays more focused branch use herbal phytoconstituents for prevention. Shikonin naphthoquinone natural dye that isolated from plants of Boraginaceae family has proven role as an anti-cancer,...
Adenium obesum commonly known as "desert rose" belongs to the family Apopcynaceae and has previously been reported for its anti-influenza, antimicrobial, cytotoxic efficacies well-known their ethno-medicinal applications. In present study, ethanolic extracts of A. (AOE) were analyzed by gas chromatography-mass spectrometry (GC-MS) identify important phytochemical compounds. The GC-MS analysis AOE detected presence 26 This plant is traditionally used treatment various diseases. this report,...
Recent times have seen a strong surge in therapeutically targeting the hedgehog (HH)/GLI signaling pathway cervical cancer. HH is reported to be crucial modulator of carcinogenesis cancer and also associated with recurrence development chemoresistance. Moreover, our previous reports established that carvacrol (CAR) inhibited proliferation prostate cells via inhibiting Notch thus, it was rational explore its antiproliferative effects cell lines. Herein, present study aimed investigate...
Background: Dates palm ( Phoenix dactylifera L.) fruits are among the most widely used in Middle East and African nations. Numerous researchers confirmed presence of phytochemicals P. L. fruit its by-products with broad-ranging biological activities. Objectives: In present work, phytochemical assessments two different cultivars date Shishi M1 Majdool M2 grown Ha’il region Saudi Arabia) have been carried out. Methods: Date were extracted analyzed by gas chromatography-mass spectrometry...
The successful chemotherapeutic regime required for the clinical management of different cancers largely depends on efficient drug delivery within cancer cells. Exosomes have emerged as an enticing candidate exploring their role vehicles. are reported to be intrinsically nanosized vesicles competent across cellular membrane. In present study, we assessed feasibility autologous exosome-based platform delivering 5-Fluorouracil (5-FU) against human colon HCT116 Autologous exosomes shown...
The Wnt signaling pathway is reported to be associated with lung cancer progression, metastasis and drug resistance, thus it an important therapeutic target for cancer. Plants have been shown as reservoirs of multiple potential anticancer agents. In the present investigation, ethanolic leaf extract Artemisia vulgaris (AvL-EtOH) was initially analyzed by means gas chromatography-mass spectrometry (GC–MS) identify phytochemical constituents. GC–MS analysis AvL-EtOH exhibited 48 peaks various...