A5103178909- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Gastrointestinal motility and disorders
- Protein Kinase Regulation and GTPase Signaling
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Liver Disease and Transplantation
- Protease and Inhibitor Mechanisms
- Endometrial and Cervical Cancer Treatments
- Chronic Lymphocytic Leukemia Research
- Congenital gastrointestinal and neural anomalies
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Neonatal Respiratory Health Research
- Calpain Protease Function and Regulation
- Gestational Diabetes Research and Management
- Neurofibromatosis and Schwannoma Cases
- Cancer Mechanisms and Therapy
- Infrared Thermography in Medicine
- Kruppel-like factors research
- Gout, Hyperuricemia, Uric Acid
Guangdong Medical College
2024
Second Hospital of Shandong University
2015-2023
Xinjiang Medical University
2023
Guangxi Medical University
2020
First Affiliated Hospital of GuangXi Medical University
2020
Qingdao University
2005-2017
Shandong University
2014
University of Michigan
2003-2010
Peking Union Medical College Hospital
1996-2006
Chinese Academy of Medical Sciences & Peking Union Medical College
1996-2006
Abstract Lysophosphatidic acid receptors stimulate a Gα12/13/RhoA-dependent gene transcription program involving the serum response factor (SRF) and its coactivator oncogene, megakaryoblastic leukemia 1 (MKL1). Inhibitors of this pathway could serve as useful biological probes potential cancer therapeutic agents. Through transcription-based high-throughput element-luciferase screening assay, we identified two small-molecule inhibitors pathway. Mechanistic studies on more potent CCG-1423 show...
The 2 closely related small GTPases, RHOC and RHOA, are involved in mammary gland carcinogenesis; however, their specific roles determining cancer cell adhesion invasion have not been elucidated.RHOA highly homologous, thereby posing a major challenge to study individual functions cells. By selectively knocking down these proteins, we able alternatively inhibit while preserving expression of the other rho protein. Quantitative analyses growth patterns aggressive estrogen receptor negative...
Objectives The ultrasound characteristics of benign and malignant thyroid nodules were compared to develop a deep learning model, aiming establish nomogram model based on image analysis improve the predictive performance nodules. Materials methods This retrospective study analyzed clinical 2247 from March 2016 October 2023. Among them, 1573 used for training testing models, 674 validation, predicted values obtained. These randomly divided into set validation in 7:3 ratio construct model....
Currently there are no reliable biological markers for ischemic stroke. The novel chemokine CXCL16 is known to be involved in the development of atherosclerosis. Nevertheless, real role atherosclerotic disorders remains uncertain. goal our study was investigate associations between serum-soluble level and stroke, including large artery atherosclerosis (LAA) small occlusion (SAO) subtypes, explore whether elevation levels correlated with severity arterial stenosis.The recruited 227 subjects,...
Treatment for breast cancer is mainly performed by surgical resection of primary tumors and chemotherapy. However, after tumor invasion metastases, hard to control. Clarification the pathogenic mechanisms would be helpful prognosis or therapy cancer. The aim this study investigate clinical prognostic implications legumain protein Materials Methods: In study, we examined mastectomy specimens from 114 matching, 26 adjacent non-cancerous tissues using immunohistochemistry.The results indicated...
To analyze the clinical and ultrasonic characteristics of breast sclerosing adenosis (SA) invasive ductal carcinoma (IDC), construct a predictive nomogram for SA.A total 865 patients were recruited at Second Hospital Shandong University from January 2016 to November 2022. All underwent routine ultrasound examinations before surgery, diagnosis was confirmed by histopathological examination following operation. Ultrasonic features recorded using Breast Imaging Data Reporting System (BI-RADS)....
The study was to investigate the role of color Doppler ultrasonography in evaluation effect Rex-bypass shunt on cavernous transformation portal vein (CTPV) children.Fifty children with symptomatic extrahepatic hypertension who received were retrospectively reviewed, and they diagnosed CTPV by ultrasonography. clinical characteristics analyzed before after operation.Forty-five patients at 6 months surgery, good patency bypass vessels displayed. platelet count significantly increased (P <...
Objective To develop an easy‐to‐use nomogram for discrimination of malignant thyroid nodules and to compare diagnostic efficiency with the Kwak American College Radiology (ACR) Thyroid Imaging, Reporting Data System (TI‐RADS). Study Design Retrospective study. Setting The Second Hospital Shandong University. Subjects Methods From March 2017 April 2019, 792 patients 1940 were included into training set; from May 2019 December 174 389 validation set. Multivariable logistic regression model was...
Breast cancer is the most common female malignancy worldwide and prognosis of triple-negative breast (TNBC) advanced patients unsatisfying. The exploration novel prognostic indicators appropriate targets crucial for improving treatment outcomes patients. cell division cycle protein 14B (CDC14B) known its roles in control, but expression status molecular function unknown. This study explores patterns clinical values CDC14B tissues. For this research, authors downloaded gene microarrays RNA...
The present case report describes a of infantile myofibromatosis (IM) with pseudo-ulcerated plaque on the right side back fetus, detected in 38th week gestation using prenatal ultrasound. fetus was examined weekly by ultrasound to measure size mass. At birth, scarlet mass slightly elevated compared skin around it, cavity center. It appeared similar an ulcerated plaque, but surface intact and smooth stratum lucidum. Thus, indicated be plaque. Three months later, had grown larger so removed...
We investigated the risk factors of nonalcoholic fatty liver disease (NAFLD) in healthy women. This is a cross-sectional study. Healthy women who underwent physical examination were enrolled. Their basic information and medical history [including age, height, weight, body mass index (BMI)], abdominal ultrasound results, and, serological indexes white blood cells, platelet count, fasting glucose, triglyceride (TG), total cholesterol, low-density lipoprotein high-density cholesterol (HDLC),...
In the rat and guinea-pig enteric nervous system, gamma-aminobutyric acid (GABA) has been shown to act as a neurotransmitter in interneurons innervating both excitatory inhibitory motor neurons, thus modulating peristalsis secretion. The present study reports on distribution of GABA-containing neurons porcine intestine by use immunocytochemistry. Duodenal, jejunal, ileal distal colonic segments were exposed vitro exogenous GABA (10(-8) M) prior fixation immunocytochemical staining supplement...