A5072833141- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Vestibular and auditory disorders
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Pituitary Gland Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Sarcoma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Migraine and Headache Studies
- Advanced Chemical Sensor Technologies
- Motor Control and Adaptation
- Hepatitis C virus research
- Ethics and Social Impacts of AI
- Vascular Anomalies and Treatments
- Biochemical and Molecular Research
- AI in Service Interactions
- Soft tissue tumor case studies
- Hearing, Cochlea, Tinnitus, Genetics
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS drug development and treatment
- Head and Neck Surgical Oncology
Klinikum Dortmund
2020-2024
Witten/Herdecke University
2024
University of Freiburg
2018-2023
The University of Notre Dame Australia
2023
University of the Free State
2023
University of Cambridge
2023
University Medical Center Freiburg
2023
Essen University Hospital
2009-2022
Inserm
2021
Sorbonne Université
2021
There is an urgent need to rapidly distinguish COVID-19 from other respiratory conditions, including influenza, at first-presentation. Point-of-care tests not requiring laboratory- support will speed diagnosis and protect health-care staff. We studied the feasibility of using breath-analysis these conditions with near-patient gas chromatography-ion mobility spectrometry (GC-IMS).
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Background Occipital nerve stimulation (ONS) has been shown to be effective for selected patients with intractable headache disorders. We performed a prospective critical evaluation of complications and direct treatment costs. Methods Twenty-seven chronic cluster (CCH, n = 24) or migraine (CM, 3) underwent trial phase bilateral ONS subsequent implantation permanent generator (IPG), if responsive according predefined criteria. Procedural long-term as well costs neuromodulation therapy were...
Objective: Neuromodulation has been recognized as a valuable surgical treatment option for patients with refractory chronic cluster headache (CCH). Due to the small number of afflicted individuals, knowledge about this specific therapy is limited. In study, we present our experiences bilateral occipital nerve stimulation (ONS) in CCH focusing on patient selection, pre- and postoperative evaluation, procedures, outcome.
It is widely accepted that action and perception in humans functionally interact on multiple levels. Moreover, areas originally suggested to be predominantly motor-related, as the cerebellum, are also involved observation. However, yet, few studies provided unequivocal evidence cerebellum coupling (APC), specifically integration of motor multisensory information for perception. We addressed this question studying patients with focal cerebellar lesions a virtual-reality paradigm measuring...
The nucleoside triphosphatase (NTPase)/helicase associated with nonstructural protein 3 of West Nile (WN) virus was purified from cell culture medium harvested virus-infected Vero cells. purification procedure included sequential chromatography on Superdex-200 and Reactive Red 120 columns, followed by a concentration step an Ultrogel hydroxyapatite column. nature the confirmed immunoblot analysis using WN virus-positive antiserum, determination its NH(2) terminus microsequencing, binding...
<h3>Background and purpose</h3> To test the hypothesis that sporadic cerebral cavernous malformations (CCMs) are systematically associated with venous (VMs) using susceptibility weighted imaging (SWI) at 7 Tesla (T) field MRI. <h3>Methods</h3> A prospective unselected series of 20 patients symptomatic or asymptomatic CCM diagnosed 1.5 T MRI was additionally scanned high resolution (250 µm<sup>2</sup> in-plane) SWI Imaging data were analysed to examine presence formation vessel structures....
We examined the influence of focal cerebellar lesions on working memory (n-back task), gait, and interaction between different gait tasks in a dual-task paradigm. The analysis included 17 young patients with chronic after tumor resection age-matched controls. Patients have shown mild to moderate ataxia. Lesion sites were basis structural magnetic resonance imaging. N-back executed levels difficulty (n = 1-4) during sitting (baseline), treadmill walking, tandem walking (dual-task conditions)....
Background: There is an urgent need to rapidly distinguish COVID-19 from other respiratory conditions, including influenza, at first-presentation. Point-of-care tests not requiring laboratory-support will speed diagnosis and protect health-care staff. We studied the feasibility of using breath-analysis these conditions with near-patient gas chromatography-ion mobility spectrometry (GC-IMS). Methods: Independent studies Edinburgh, UK, Dortmund, Germany, recruited adult patients possible...
Hemangioblastoma (HB) is mainly located in the brain and spinal cord. The tumor composed of two major components, namely neoplastic stromal cells abundant microvessels. Thus, hyper‐vascularization hallmark this tumor. Despite identification germline and/or epigenetic mutations Von Hippel Lindau ( VHL ) gene as an important pathogenic mechanism HB, little known about molecular signaling involved highly vascularized present study investigated key players multiple angiogenic pathways including...
Neovascularization and peritumoral edema are hallmarks of glioblastoma (GBM). Programmed cell death 10 (PDCD10) plays a pivotal role in regulating apoptosis, neoangiogenesis vessel permeability is implicated certain tumor signaling pathways. However, little known about PDCD10 GBM. We aimed to investigate the expression pattern identify association its with some molecular clinical parameters human mRNA protein were examined respectively by real-time RT-PCR Western blotting GBM (n = 27),...
Objective Extent of resection (EOR) and Karnofsky Performance Status (KPS) are at odds in glioblastoma (GBM) surgery, that is, the anticipated postoperative disability limits EOR. This study analyzes correlation different surgical modalities with resulting physical status survival patients GBM. Methods A total 565 primary GBM were operated on a single institution between 2006 2014. Possible comprised supratotal (SLR), gross (GTR; ≥ 95% by volume), tumor debulking (TDB; ≤ stereotactic biopsy...
To enhance the inhibitory potential of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) vs hepatitis C virus (HCV) NTPase/helicase, ribavirin-5'-triphosphate (ribavirin-TP) was synthesized and investigated. Ribavirin-TP prepared with use modified Yoshikawa-Ludwig-Mishra-Broom procedure (cf. Mishra & Broom, 1991, J. Chem. Soc., Commun, 1276-1277) involving phosphorylation unprotected nucleoside. Kinetic analysis revealed enhanced ribavirin-TP (IC50=40 microM) as compared to...
Background and Study Aim: Early diagnosis of ventriculostomy-related infection (VRI) is crucial for the early treatment course this disease. In neurosurgical patients diagnostic criteria are equivocal, mostly because bloodstained cerebrospinal fluid (CSF). The predictive value, sensitivity specificity intrathecal interleukin-6 (IL-6CSF) has been proven VRI compared with classical CSF parameters, i.e. cell countCSF (CCCSF) total proteinCSF.
Traditionally, cerebellar disorders including ataxias have been associated with deficits in motor control and learning. Since the 1980's growing evidence has emerged that diseases also impede cognitive affective processes such as executive linguistic functions, visuospatial abilities regulation of emotion affect. This combination non-motor symptoms named Cerebellar Cognitive Affective/ Schmahmann Syndrome (CCAS). To date, diagnosis relies on non-standardized bedside examination and, if...
(2001). Efficacy of Short-course Therapy with the Ketolide Telithromycin Compared 10 Days Penicillin V for Treatment Pharyngitis/Tonsillitis. Scandinavian Journal Infectious Diseases: Vol. 33, No. 12, pp. 883-890.
Objective: Intracranial aneurysms (IAs) require deliberately selected treatment strategies as they are incrementally found prior to rupture and deleterious subarachnoid haemorrhage (SAH). Multiple recurrent necessitate both neurointerventionalists neurosurgeons optimize aneurysmal occlusion in an interdisciplinary effort. The present study was conducted condense essential from a single neurovascular centre with regard the lessons learned. Method: Medical charts of 321 consecutive patients...
Stimulation of the greater occipital nerve has been employed for various intractable headache conditions more than a decade. Still, prospective studies that correlate stimulation with outcome patients respect to alleviation are sparsely found in literature.To identify anatomical landmarks reproducible nerve. For clinical implication, individual response therapy refractory chronic cluster undergoing was correlated postoperative localization electrodes and distribution field.Prospective...