A5015096183- Cutaneous Melanoma Detection and Management
- Innovations in Medical Education
- Telemedicine and Telehealth Implementation
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- COVID-19 and healthcare impacts
- Cancer Cells and Metastasis
- Ultrasound and Hyperthermia Applications
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Melanoma and MAPK Pathways
- Neurofibromatosis and Schwannoma Cases
- Higher Education Practises and Engagement
- Extracellular vesicles in disease
- Online and Blended Learning
- Nanowire Synthesis and Applications
- Educational Technology and Pedagogy
- Inflammasome and immune disorders
- Microfluidic and Bio-sensing Technologies
- Online Learning and Analytics
- Skin Protection and Aging
- Radiation Dose and Imaging
- Cancer, Hypoxia, and Metabolism
- Public Health Policies and Education
UNM Comprehensive Cancer Center
2024
University of New Mexico
2024
Scripps Clinic
2022-2024
New Mexico Cancer Center
2024
Scripps Health
2023
Scripps MD Anderson Cancer Center
2023
Cleveland Clinic
2019-2021
UC San Diego Health System
2021
University of California, San Diego
2021
The University of Texas Health Science Center at Houston
2013-2019
Introduction: The role of medical students in catalyzing and leading curricular change US schools is not well described. Here, American Medical Association student physician leaders the Accelerating Change Education initiative use qualitative methods to better define leadership change.Methods: authors developed case studies describing efforts. Case were presented at a national education workshop; participants provided worksheet reflections surveyed, responses transcribed. Kotter's management...
Abstract Telemedicine training was not a substantial element of most residency programmes prior to the COVID-19 pandemic. Social distancing measures changed this. The Cleveland Clinic Internal Medicine Residency Programme (IMRP) is one largest in USA, which made task implementing telemedicine curriculum more complex. Here we describe our experience an effective, expedited for ambulatory resident clinics. This study started April 2020 when implemented resident-led and programme providing...
Dendritic cells (DC) process and present antigens to T lymphocytes, inducing potent immune responses when encountered in association with activating signals, such as pathogen-associated molecular patterns. Using the 4T1 murine model of breast cancer, cationic liposomes containing monophosphoryl lipid A (MPL) interleukin (IL)-12 were administered by intratumoral injection. Combination multivalent presentation Toll-like receptor-4 ligand MPL cytotoxic 1,2-dioleoyl-3-trmethylammonium-propane...
Porous silicon (pSi) microparticles, in diverse sizes and shapes, can be functionalized to present pathogen-associated molecular patterns that activate dendritic cells. Intraperitoneal injection of MPL-adsorbed pSi contrast free MPL, resulted the induction local inflammation, reflected recruitment neutrophils, eosinophils proinflammatory monocytes, depletion resident macrophages mast cells at site. Injection microparticle-bound MPL enhanced secretion T helper 1 associated cytokines IFN-γ...
The COVID-19 pandemic has been transformative for healthcare and medical education. Physician trainees the education system that serves them adapted quickly so could finish academic year on time advance to next phase of training without compromising clinical competency or public safety. Systemic changes have had most significant impact telemedicine training, virtual learning, secure testing, interview process residency fellowship positions. Trainees are now getting regular, supervised...
Herein, we present a novel imaging platform to study the biological effects of non-invasive radiofrequency (RF) electric field cancer hyperthermia. This system allows for real-time in vivo intravital microscopy (IVM) radiofrequency-induced alterations such as changes vessel structure and drug perfusion. Our results indicate that IVM is able handle exposure high-power electric-fields without inducing significant hardware damage or artifacts. Furthermore, short durations low-power (< 200 W)...
Neuroblastoma is the most common malignancy in infants. Overexpression of epidermal growth factor receptor (EGFR) neuroblastoma tumors underlies resistance to chemotherapeutics. UBE4B, an E3/E4 ubiquitin ligase involved EGFR degradation, located on chromosome 1p36, a region which loss heterozygosity observed approximately one-third and correlated with poor prognosis. In chemoresistant cells, depletion UBE4B yielded significantly reduced cell proliferation migration, enhanced apoptosis...
Abstract Background Combination immune checkpoint blockade targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte associated 4 (CTLA-4) leads to high response rates improved survival in patients with advanced cutaneous melanoma (CM). Less is known about the efficacy of this combination acral lentiginous (ALM). Objectives To determine PD-1 CTLA-4 a diverse, real-world population ALM. Methods This multi-institutional retrospective study analysed histologically confirmed...
Aim: This study determined the characteristics of patients with early-stage melanoma (IA-IIA) who later had stage IV recurrence.Patients & methods: We retrospectively examined 880 and identified those progressed to disease from an initial (n = 50).Results: observed a median latent period 4 years between diagnosis metastatic disease. More (54%) developed or diagnosis. 34% regular dermatology appointments, 30% oncology follow-up. Lung brain were most common sites.Conclusion: Long term...
Abstract Introduction Telemedicine is an important element of healthcare. However, until the COVID-19 pandemic, training in telemedicine was not a substantial most residency programs. Social distancing measures changed this. The Cleveland Clinic Internal Medicine Residency Program (IMRP) one largest programs United States, which made task developing and adopting effective, expedited curriculum challenging. Our goal to implement system for teaching care skills supervising provided by...
e22505 Background: Decreasing unprotected exposure to ultraviolet (UV) radiation during childhood can significantly decrease the risk of developing skin cancer as an adult. School-based sun safety curricula have demonstrated efficacy in teaching young adults about harms prolonged, UV and been effective increasing practices. This project provided a 50-min curriculum high school students at public San Diego, CA just prior summer break 2022. The addressed factors, protection methods, benefits...
Breaking bad news (BBN) is a critically important skill set for residents. Limited formal supervision and unpredictable timing of delivery serve as barriers to the exchange meaningful feedback.The goal this educational innovation was improve internal medicine residents' communication skills during challenging BBN encounters. A training programme innovative on-demand task force were part two-phase project.Internal residents at large academic medical centre participated in an interactive...
e24055 Background: Despite an encouraging 99% five-year survival in patients diagnosed with early-stage melanoma, a higher proportion of fatal melanomas initially present thin ( < 1mm) rather than thick > 4mm) melanoma. 1 Therefore, melanoma survivorship remains topic high interest. We examined cohort which progressed to stage IV inform and risk-stratification approaches this large, understudied population. Methods: From retrospective single-center study 880 consecutive from 2016-2020,...
113 Background: Farmworkers are at increased risk for skin cancer because of occupational exposure to sun and pesticides. In 2017/2018, Farmworker Justice conducted the Unidos community mobilization project raise skin-cancer awareness promote care access in farmworker communities. Unmet needs were identified follow-up coordination patients who screened positive a suspicious lesion. We undertook this ReUnidos study document incidence evaluate benefits health-navigator program facilitate care....
Abstract Nanoparticles, such as liposomes, provide opportunities to simultaneously present antigens and immune modulators. Using a 4T1 murine model of breast cancer, cationic nanoliposomal formulation containing monophosphoryl lipid A the 1,2-dioleoyl-3-trimethylammonium-propane induced anti-tumor activity following intratumoral administration. Addition recombinant interleukin-12 (IL-12) further suppressed tumor growth augmented T helper-1 cell (Th-1) polarization, with enhanced infiltration...
Purpose: The sad truth is that cancer blamed for the death of nearly one in four people US. Immunotherapy offers hope stimulating immunity leading to targeted killing cells and a preventative measure recurrence. Unfortunately, clinical efficacy immunotherapy has not yet been established, however novel approaches are being developed, including combining with traditional chemotherapy, radiotherapy or thermal therapy. Therapeutics such as radiofrequency (RF) ablation select chemotherapeutics...
e21551 Background: Cutaneous squamous cell carcinoma (CSCC) is the 2 nd most common malignancy in US. Approximately 10% of patients will experience either recurrent or metastatic disease, leading to worsened morbidity and mortality. In 2019, anti-PD1 therapy was FDA approved for unresectable CSCC, has been established as standard frontline systemic this disease. Here we present our long-term, follow-up data investigating efficacy, safety, durability PD-1 CSCC. Methods: This a retrospective...