A5069613378- Thyroid Disorders and Treatments
- Statistical Methods and Bayesian Inference
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Systemic Lupus Erythematosus Research
- Statistical Methods and Inference
- Diabetes Treatment and Management
- Cancer Genomics and Diagnostics
- Retinal and Optic Conditions
- Diet and metabolism studies
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Statistical Methods in Clinical Trials
- Ocular Diseases and Behçet’s Syndrome
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Neutropenia and Cancer Infections
- Nutritional Studies and Diet
- Birth, Development, and Health
- Chronic Lymphocytic Leukemia Research
- Cancer Risks and Factors
- Heart Failure Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
Danish Cancer Society
2023-2025
University of Copenhagen
2018-2024
Leiden University Medical Center
2015-2018
Combined Ophthalmic Research Rotterdam
2018
Background: Increased public attention toward health and quality-of-life issues has led to more intensified screening for various medical conditions, including hypothyroidism. A falling serum thyrotropin (s-TSH) at initiation of levothyroxine (LT4) treatment been reported in the United Kingdom between 2001 2009, indicating a TSH threshold, which may lead less benefit from therapy possibly overtreatment. The aim this study was investigate changes s-TSH threshold used by general practitioners...
The Copenhagen General Practice Laboratory (CGPL) was founded in 1922 to provide paraclinical analyses the primary health-care sector Copenhagen. At end of 2015, CGPL closed and CopLab database established make data available for research.
Parkinson's disease is a progressive neurodegenerative disorder with no cure. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) may have neuroprotective effects. However, long-term real-world studies are needed to clarify their potential impact on disease. This nationwide cohort study included 33,462 patients (16,731 GLP-1RA initiators and 16,731 propensity score-matched dipeptidyl peptidase-4 inhibitor [DPP-4i] initiators) from 2007 2018, followed until 2022. Eligible participants were ≥...
Abstract Context Thyroid hormones are critical for neural development, and during the first trimester of pregnancy, fetus relies fully on maternal thyroid hormone production. Objective To investigate associations between levels in with child's school performance, risk attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD). Methods Information from Copenhagen Primary Care Laboratory Pregnancy Database TSH free thyroxine measurements mothers children born 2000 through 2014 were...
In multi-state models, the expected length of stay (ELOS) in a state is not straightforward object to relate covariates, and traditional approach has instead been construct regression models for transition intensities calculate ELOS from these. The disadvantage this that effect covariates on easily translated into ELOS, it typically relies Markov assumption. We propose use pseudo-observations thereby allowing direct interpretation covariate effects while at same time avoiding For approach,...
Abstract Background The prevalence of chronic kidney disease (CKD) is increasing globally. Early diagnosis in primary care may have a role ensuring proper intervention. We aimed to determine the and outcome CKD care. Methods performed an observational cohort study Copenhagen (2001–2015). Outcomes were stroke, myocardial infarction (MI), heart failure (HF), peripheral artery (PAD), all-cause- cardiovascular mortality. combined individuals with normal function stage 2 as reference. conducted...
A decrease over time in thyroid stimulating hormone (TSH) levels when initiating levothyroxine (L-T4) therapy for hypothyroidism has been reported, where treatment most often is initiated with TSH below 10 mIU/L. The primary objective of this study was to investigate whether lower threshold resulted an increased number overtreated patients.Retrospective cohort comprising inhabitants Copenhagen had measurements requested by general practitioners which led a new prescription L-T4 between 2001...
Pseudo-observations have been introduced as a way to perform regression analysis of mean value parameter related right-censored time-to-event outcome, such the survival probability or restricted time. Since introduction approach there several extensions from original setting. However, proper definition and performance pseudo-observations under left-truncation has not yet addressed. Here, we look at two types right-censoring left-truncation. We explored their in simulation study applied them...
Background: Elastography can be measured with different imaging techniques and is increasingly used for noninvasive assessment of hepatic fibrosis. Little known about the performance, interrelation elastographic techniques, in prediction fibrosis pediatric liver disease. Objectives: We aimed to determine discriminatory value advanced (Metavir F3-4) evaluate applicability 2D shear wave ultrasound elastography (USe), Transient (TE) Magnetic Resonance (MRe) Methods: In patients disease aged...
Measurement of B-type natriuretic peptide (BNP) in plasma may have its greatest potential primary care, as general practitioners need to rapidly identify patients who warrant further medical review. The aim the present study was examine prognostic information BNP measurement on all-cause mortality a large Danish care cohort.This covered cohort (n = 61665) with median follow-up period 4.36 years (interquartile range, 2.29-6.62 years). measured using ADVIA Centaur/CentaurXP platform....
Abstract To investigate possible biochemical abnormalities associated with celiac disease (CD) antibody positivity in a primary health care setting and thereby identify predictors that could potentially reduce diagnostic delay underdiagnosis of CD. This observational cohort study included measurements CD antibodies the Copenhagen Primary Care Laboratory (CopLab) database from 2000 to 2015; was defined as tissue transglutaminase IgA or IgG ≥ 7 kU/L and/or deamidated gliadin peptide 10 kU/L....
The dynamics of pre-diagnostic lymphocytosis in patients with ensuing chronic lymphocytic leukemia (CLL) need to be explored as a better understanding disease progression may improve treatment options and even lead avoidance approaches. Our aim was investigate the development prior diagnosis population-based cohort CLL assess prognostic information these measurements.All diagnosed Greater Copenhagen area between 2008 2016 were included study. Pre-diagnostic blood test results obtained from...
Purpose The Copenhagen Primary Care Laboratory Pregnancy (CopPreg) database was established based on data from Danish Medical Birth Register and the (CopLab) database. aim to provide a biomedical epidemiological resource for research in early disease programming (eg, parental clinical biomarker levels pregnancy/ birth outcomes or long-term health offspring). Participants cohort consisted total of 203 608 women (with 340 891 pregnancies) who gave 348 248 children with 200 590 related fathers....
Abstract In recent years there have been a series of advances in the field dynamic prediction. Among those is development methods for prediction cumulative incidence function competing risk setting. These models enable predictions to be updated as time progresses and more information becomes available, example when patient comes back follow‐up visit after completing year treatment, death, adverse events may changed since treatment initiation. One approach model risks by direct binomial...
Abstract Background Lipid levels in blood have decreased considerably during the past decades general population partly due to use of statins. This study aims investigate trends lipid between 2001 and 2018 a statin-free from primary health care, overall by sex age. Methods In cohort 634,119 patients practice with no diagnoses or medical treatments that affected total cholesterol (TC; n = 1,574,339) were identified. Similarly, measurements low-density lipoprotein (LDL-C; 1,302,440),...
Abstract Objective The incidence of hypothyroidism is not expected to differ by socioeconomic factors. However, the decision test and initiate treatment may differ. We aimed examine whether educational level influences probability thyroid stimulation hormone (TSH)‐measurement initiation levothyroxine treatment. Design Citizens in greater Copenhagen Area during 2001‐2015 were included. Individual‐level data on level, diagnoses, GP‐contact, TSH‐measurement medication derived from...
Uveitis is characterised as a recurrent inflammation of the eye and an ongoing can have severe impact on visual acuity patient. The Rotterdam Eye Hospital has been collecting data every uveitis patient visiting hospital since 2000. We propose joint model for with purpose making dynamic predictions. Dynamic prediction models allow predictions to be updated during follow‐up based patient's disease history. consists submodel inflammation, event history outcome, one acuity, longitudinal outcome....