A5027404682- Bladder and Urothelial Cancer Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Urinary and Genital Oncology Studies
- Hemodynamic Monitoring and Therapy
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Long-Term Effects of COVID-19
- Hip and Femur Fractures
- SARS-CoV-2 and COVID-19 Research
- Aortic aneurysm repair treatments
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Colorectal Cancer Screening and Detection
- Intensive Care Unit Cognitive Disorders
- Genetic factors in colorectal cancer
- Urological Disorders and Treatments
- Chronic Disease Management Strategies
- Frailty in Older Adults
- Esophageal Cancer Research and Treatment
- Renal and related cancers
- Pelvic floor disorders treatments
York Teaching Hospital NHS Foundation Trust
2014-2025
North Yorkshire County Council
2023-2025
York Hospital
2010-2024
Digital Research Alliance of Canada
2022-2024
Royal Alexandra Hospital
2024
Hull York Medical School
2021-2023
Sheffield Teaching Hospitals NHS Foundation Trust
2013-2023
James Cook University Hospital
2021-2022
UPMC Health System
2021
University of Pittsburgh
2021
Abstract Purpose: New methods to accurately predict an individual tumor behavior are urgently required improve the treatment of cancer. We previously found that promoter hypermethylation can be accurate predictor bladder cancer progression, but it is not specific. Here, we investigate a panel methylated loci in prospectively collected cohort tumors determine whether has useful role management patients with Experimental Design: Quantitative methylation-specific PCR was done at 17 gene...
No AccessJournal of UrologyAdult urology1 May 2007Behavior Urothelial Carcinoma With Respect to Anatomical Location J.W.F. Catto, D.R. Yates, I. Rehman, A.R. Azzouzi, J. Patterson, M. Sibony, O. Cussenot, and F.C. Hamdy CattoJ.W.F. Catto Academic Urology Unit, University Sheffield, United Kingdom More articles by this author , YatesD.R. Yates RehmanI. Rehman AzzouziA.R. Azzouzi Service d’Urologie, Centre Hospitalier Universitaire d’Angers, Angers, Paris, France PattersonJ. Patterson...
No AccessJournal of UrologyAdult Urology1 May 2013Prediction Cancer Specific Survival After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: Development an Optimized Postoperative Nomogram Using Decision Curve Analysis Morgan Rouprêt, Vincent Hupertan, Thomas Seisen, Pierre Colin, Evanguelos Xylinas, David R. Yates, Harun Fajkovic, Yair Lotan, Jay D. Raman, Richard Zigeuner, Mesut Remzi, Christian Bolenz, Giacomo Novara, Wassim Kassouf, Adil Ouzzane, François Rozet, Olivier...
What's known on the subject? and What does study add? Numerous urological procedures can now be performed with robotic assistance. Though not definitely proven to superior conventional laparoscopy or traditional open surgery in setting of a randomised trial, experienced centres robot‐assisted allows for excellent surgical outcomes is valuable tool augment modern practice. Our review highlights depth history that underpins platform we utilise today, whilst also detailing current place urology...
Abstract Purpose: The diagnosis of localized prostate cancer is difficult due to a lack cancer-specific biomarkers. Many patients require repeat biopsies diagnose the disease. We investigated whether aberrant promoter hypermethylation in prostatic fluid could reliably detect cancer. Experimental Design: Urine samples were collected after massage from 95 with undergoing radical prostatectomy (63 pT1, 31 pT2, and 1 pT3) 38 control patients. Ten genes (GSTP1, RASSF1a, ECDH1, APC, DAPK, MGMT,...
Owing to the scarcity of upper urinary tract urothelial carcinoma (UUT-UC) it is often necessary for investigators pool data. A patient-specific survival nomogram based on such data needed predict cancer-specific (CSS) post nephroureterectomy (NU). Herein, we propose and validate a CSS NU. Twenty-one French institutions contributed 1120 patients treated with NU UUT-UC. total 667 had full development. Study population was divided into development cohort (397) external validation (270). Cox...
Study Type – Diagnostic (exploratory cohort) Level of Evidence 3a What's known on the subject? and What does study add? Hereditary non‐polyposis colorectal cancer (HNPCC), also as Lynch syndrome, is an autosomal dominant multi‐organ syndrome. Upper urinary tract urothelial carcinomas belong to HNPCC‐related tumours rank third within this group after endometrial cancer. However, many urologists are not aware association it presumed that some hereditary cancers misclassified sporadic their...
To propose and validate a nomogram to predict cancer-specific survival (CSS) after radical nephroureterectomy (RNU) in patients with pT1-3/N0-x upper tract urothelial carcinoma (UTUC).The international the French national collaborative groups on UTUC pooled data from 3387 treated RNU. Only 2233 chemotherapy naïve were included present study. The population was randomly split into development cohort (1563) external validation (670). build nomogram, logistic regressions used for univariable...
Pre-operative intervention to improve general health and readiness for surgery is known as prehabilitation. Modification of risk factors such physical inactivity, smoking, hazardous alcohol consumption an unhealthy weight can reduce the peri-operative morbidity patient outcomes. Interventions may need target multiple behaviours. The acceptability patients unclear. We explored motivation, confidence priority changing behaviours before short-term benefits in comparison with long-term benefits....
Abstract Promoter hypermethylation of circulating cell DNA has been advocated as a diagnostic marker for prostate cancer, but its prognostic use is currently unclear. To assess this role, we compared from cancer patients with (Group 1, n = 20) and without 2, 22) disease progression age‐matched controls (benign prostatic hyperplasia, Group 3, 22). We measured 10 gene promoters in 2 sequential venous samples, obtained at diagnosis during (median time, 15 months later). Matched time samples...