A5101640724- Microbial Metabolic Engineering and Bioproduction
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Data Stream Mining Techniques
- Web Application Security Vulnerabilities
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Biosensing Techniques and Applications
- Microbial Metabolism and Applications
- Biofuel production and bioconversion
- SARS-CoV-2 and COVID-19 Research
- Identification and Quantification in Food
- Pharmaceutical and Antibiotic Environmental Impacts
- Probiotics and Fermented Foods
- Advanced Malware Detection Techniques
- Mycotoxins in Agriculture and Food
- Machine Learning in Bioinformatics
- Folate and B Vitamins Research
- Influenza Virus Research Studies
- Analytical Chemistry and Chromatography
- vaccines and immunoinformatics approaches
- Protein Structure and Dynamics
- Forensic Toxicology and Drug Analysis
University of Chinese Academy of Sciences
2019-2023
Shanghai Institute of Nutrition and Health
2019-2023
Institute of Information Engineering
2022
Chinese Academy of Sciences
2012-2022
Shanghai Institutes for Biological Sciences
2019-2020
Beijing Institute of Genomics
2012
Abstract To increase the number of value-added chemicals that can be produced by metabolic engineering and synthetic biology, constructing space with novel reactions/pathways is crucial. However, large reactions existed in complicated metabolisms within hosts, identifying pathways linking two molecules or heterologous when a host to produce target molecule an arduous task. Hence, we built user-friendly web server, novoPathFinder, which has several features: (i) enumerate between specified...
Fermentation products, together with food components, determine the sense, nutrition, and safety of fermented foods. Traditional methods fermentation product identification are time-consuming cumbersome, which cannot meet increasing need for extensive bioactive metabolites produced during fermentation. Hence, we propose a data-driven integrated platform (FFExplorer, http://www.rxnfinder.org/ffexplorer/) based on machine learning data 2,192,862 microbial sequence-encoded enzymes computational...
The mechanisms underlying drug addiction remain nebulous. Furthermore, new psychoactive substances (NPS) are being developed to circumvent legal control; hence, rapid NPS identification is urgently needed. Here, we present the construction of comprehensive database controlled substances, AddictedChem. This integrates following information on from US Drug Enforcement Administration: physical and chemical characteristics; classified literature by Medical Subject Headings terms target binding...
Abstract Addition of chemical structural information in enzymatic reactions has proven to be significant for accurate enzyme function prediction. However, such data lack systematic feature mining and hardly exist enzyme-related databases. Therefore, global will offer a unique landscape researchers understand the basic functional mechanisms natural bioprocesses facilitate annotation. Here, we established new knowledge base called EnzyMine, through which propose elucidate reaction features...
The Unified Extensible Firmware Interface (UEFI) provides a specification of the software interface between an OS and its underlying platform firmware. runtime services provided are seemingly secure as they reside in System Management Mode (SMM) at ring -2, assuming higher privilege than kernel 0. However, their vulnerabilities known to be exploitable launch 0 -2 escalation, i.e., SMM escalation attacks.In this paper, we introduce effective static analysis framework for detecting UEFI We...
Biosynthesis is a promising method for chemical synthesis. However, due to varieties between different microorganism hosts, yield and heterologous pathways needed production of target may also vary from strains. One the main challenges in metabolic engineering select an appropriate chassis host specified production. with thousands microorganisms existing nature extremely complicated metabolism within them, it still time-consuming error-prone work achieve such goal only through experimental...
Molecular scaffolds are useful in medicinal chemistry to describe, discuss and visualize series of chemical compounds, biochemical transformations associated biological properties.Here, we present RxnBLAST as a web-based tool for analyzing scaffold reactive environment features bioreactions. extracts from bioreactions including atom-atom mapping, reaction centers, rules functional groups help understand compositions patterns. Core-to-Core is proposed, which can be utilized networks...
The 2019 novel coronavirus outbreak has significantly affected global health and society. Thus, predicting biological function from pathogen sequence is crucial urgently needed. However, little work been conducted to identify viruses by the enzymes that they encode, which are key propagation.We built a comprehensive scientific resource, SARS2020, integrates coronavirus-related research, genomic sequences results of anti-viral drug trials. In addition, we consensus sequence-catalytic model...
For each variant in a genome-wide association study, the risk allele is one with an odds ratio greater than 1. given set of variants, number alleles cases minus that controls evaluated and p-value obtained for this difference. Successive sums these differences over best 2, 3, etc. variants associated p-values are obtained. The smallest such our test statistic, which empirical significance level by permutation analysis. Applied to disease datasets, approach furnishes significant results even...
ABSTRACT Summary The field of synthetic biology lacks a comprehensive knowledgebase for selecting target molecules according to their functions, economic applications and known biosynthetic pathways. We implemented ChemHub, containing >90 000 chemicals along with related biosynthesis information these that was manually extracted from >600 published studies by more than 100 people over the past 10 years. Availability implementation Multiple algorithms were enable pathway design...
Advances in metabolic engineering have boosted the production of bulk chemicals, resulting tons volumes some chemicals with very low prices. A decrease cost and overproduction makes it necessary desirable to explore potential synthesize higher-value products from them. It is also useful important for society use design methods involving synthetic biology increase economic value these chemicals. Therefore, we developed 'BioBulkFoundary', which provides an elaborate analysis biosynthetic based...