A5087612677- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Osteoarthritis Treatment and Mechanisms
- Genetic Associations and Epidemiology
- Total Knee Arthroplasty Outcomes
- Blood transfusion and management
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Fatty Acid Research and Health
- Advanced Glycation End Products research
- Wound Healing and Treatments
- Genetic and phenotypic traits in livestock
- Skin Protection and Aging
- Cardiovascular Effects of Exercise
- Biological and pharmacological studies of plants
- Rheumatoid Arthritis Research and Therapies
- Therapeutic Uses of Natural Elements
- Acne and Rosacea Treatments and Effects
- Generative Adversarial Networks and Image Synthesis
- Biofield Effects and Biophysics
- Inflammatory mediators and NSAID effects
- Spondyloarthritis Studies and Treatments
- Consumer Attitudes and Food Labeling
Xiangya Hospital Central South University
2017-2025
Central South University
2017-2025
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
SKiN Health
2021-2022
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2021
National Engineering Research Center of Electromagnetic Radiation Control Materials
2020
State Key Laboratory of Electronic Thin Films and Integrated Devices
2020
Hohhot Minzu College
2020
Inner Mongolia University
2015
Purpose It has been found that childhood obesity (CO) may play an important role in the onset and progression of osteoarthritis (OA). Thus we conducted this mendelian randomisation analysis (MR) to evaluate causal association between osteoarthritis.Methods Instrumental variables (IVs) were obtained from publicly available genome-wide study datasets. The leave-one-out sensitivity test, MR Pleiotropy RESidual Sum Outlier test (MR-PRESSO), Cochran's Q used confirm heterogeneity pleiotropy...
Background Previous observational studies have found an association between inflammatory bowel disease (IBD) and psoriasis. Using the mendelian randomization (MR) approach, we aim to determine whether there was a causal IBD Methods We performed two-sample MR with genetic instruments identified for its main subtypes, Crohn’s (CD) ulcerative colitis (UC), from genome-wide study (GWAS) involving 25,042 cases diagnosis 34,915 controls. Summarized data psoriasis were obtained different GWAS which...
Previous studies have reported a potential association of polyunsaturated fatty acids (PUFAs) levels with allergic disease risk and the possible benefit PUFAs supplementation on prevention. This study was performed to estimate genetic between diseases using method both univariable multivariable two-sample Mendelian randomization (MR).As indicators levels, we included omega-3, omega-6, docosahexaenoic acid (DHA), eicosapentaenoic (EPA), linoleic (LA), ratio omega-6 omega-3 (omega-6:3)....
Abstract Previous evidence has suggested that childhood sunburn could be a risk factor for cutaneous malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, existing observational studies not reveal the causal associations genetically. This study aimed to investigate whether there was genetic relationship between cancers. Univariable Mendelian randomization (MR) Causal Analysis Using Summary Effect analysis carried out estimates evaluation horizontal pleiotropy. Multivariable...
This study aimed at exploring the potential causal effects of leisure sedentary behavior (LSB) on common types arthritis. Two-sample Mendelian randomization (MR), including both univariable MR (UVMR) and multivariable (MVMR) analysis, was performed to explore LSB risk several arthritis, osteoarthritis, rheumatoid arthritis (RA), psoriatic (PsA). Genetic variants from genome-wide association studies (GWAS) LSBs for time spent television watching, computer use, driving were obtained UK...
Despite advances in cancer biomarkers and targeted therapies, early diagnosis treatment of inflammatory skin diseases remain challenging. This study aims to identify circulating proteins causally linked diseases, including acne, atopic dermatitis, systemic lupus erythematosus, psoriasis, rosacea, urticaria, through a Mendelian randomization (MR) framework. A large-scale MR analysis was performed assess the causal effects thousands plasma on common diseases. Additional methods, Steiger...
Background . Hip fractures of elderly patients are a public health problem worldwide, mostly lying in bed for long time; therefore, the importance life quality such is an issue beyond question. Orem’s self-care model nursing pattern which introduced with purpose improving ability individuals, especially suffering from diseases limits on activity. Objective The aim this study was to determine effects program senile hip fractures. Methods A randomized clinical trial conducted 130 eligible old...
Abstract The coronavirus disease (COVID-19) is an infectious caused by the most recently discovered coronavirus, severe acute respiratory syndrome 2 (SARS-CoV-2). This study aims to investigate associations between sunlight and vitamin D, using latitude as indicator, with COVID-19 cases related deaths in United States. General regression Chi-square test were used examine deaths. analyses indicated that latitudes marginally associated (p = 0.0792) 0.0599), increase of 2491 189 total numbers...
Previous studies have proven that ultraviolet (UV)-based phototherapy, including UVB or psoralen UVA (PUVA), and their combination therapies, is effective for psoriasis treatment.To compare the clinical efficacy adverse events (AEs) of different UV-based phototherapy in psoriasis.PubMed, Cochrane Library, Scopus Embase were systematically searched. A random-effect model network meta-analysis with frequentist framework was performed, results reported as risk ratios (RRs) 95% CI. The main...
To explore whether there is a genetic causal relationship between sleep traits and the risk of autoimmune arthritis (AA).
There is growing evidence that atrial fibrillation (AF) a risk factor for cognitive impairment (CI) and dementia in the presence or absence of stroke. The purpose this study was to explore mechanism CI caused by AF.
Previous studies confirmed that chronic arsenic exposure could lead to pigmentary changes and hyperkeratosis. However, skin health-related quality of life (HRQoL) among people under lifetime remains underappreciated. Our study is aimed at investigating several patient-reported outcomes in a population exposure. Patients Methods. A cross-sectional was conducted communities Shimen, China. Dermatologists performed examinations for participants. Patient-reported (PROs) included HRQoL, itch,...
Objective . To investigate the effects of emodin on nitric oxide (NO) secretion induced by high glucose in human umbilical vein endothelial cells (HUVECs) through p-Akt signaling pathway. Methods Sensitivity to was determined MTT assay establish experimental concentrations; then, HUVECs were treated with high-dose (33.3 mmol/L) (HG), HG + (HG E), Akt phosphorylation inhibitor LY294002 LY), or E LY. The (Ser 473) expression 48 h analyzed using Western blot. NO effect nitrate reductase assay....
Objective: The effect of processed foods on atopic dermatitis (AD) in adults is unclear. This study was to evaluate the association between and AD Chinese adult population. Design: included three population-based cross-sectional studies using cluster sampling by villages, institutions, or factories. Participants underwent dermatological examinations certificated dermatologists a food frequency questionnaire survey. A spot urine sample collected estimate daily sodium intake. Adjusted odds...
Observational research reported the underlying correlation of metabolic syndrome (MetS) and its components with rotator cuff tendinopathy (RCT), but their causality remained unclear. This study aimed to investigate whether genetically predicted MetS was related risk RCT.Both univariable multivariable Mendelian randomization (MR) analysis applied using summary-level data from most comprehensive genome-wide association studies estimate associations component RCT, inverse variance weighted...
Abstract Background While numerous allergy-related biomarkers and targeted treatment strategies have been developed employed, there are still signifcant limitations challenges in the early diagnosis for allegic diseases. Our study aims to identify circulating proteins causally associated with allergic disease-related traits through Mendelian randomization (MR)-based analytical framework. Methods Large-scale cis-MR was employed estimate effects of thousands plasma on five main Additional...