A5028674061- Osteoarthritis Treatment and Mechanisms
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Genetic Associations and Epidemiology
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Orthopaedic implants and arthroplasty
- Blood transfusion and management
- Acute Ischemic Stroke Management
- Inflammatory mediators and NSAID effects
- Spine and Intervertebral Disc Pathology
- SARS-CoV-2 and COVID-19 Research
- Total Knee Arthroplasty Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Neuropeptides and Animal Physiology
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Biological and pharmacological studies of plants
- Genetic and phenotypic traits in livestock
- IL-33, ST2, and ILC Pathways
- Fatty Acid Research and Health
- Venous Thromboembolism Diagnosis and Management
Xiangya Hospital Central South University
2021-2025
Central South University
2019-2025
Emory University
2004-2024
Anhui University of Traditional Chinese Medicine
2023-2024
University of Michigan
2023
University of Alabama at Birmingham
2004-2022
Second Xiangya Hospital of Central South University
2019-2021
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2021
Purpose It has been found that childhood obesity (CO) may play an important role in the onset and progression of osteoarthritis (OA). Thus we conducted this mendelian randomisation analysis (MR) to evaluate causal association between osteoarthritis.Methods Instrumental variables (IVs) were obtained from publicly available genome-wide study datasets. The leave-one-out sensitivity test, MR Pleiotropy RESidual Sum Outlier test (MR-PRESSO), Cochran's Q used confirm heterogeneity pleiotropy...
Background Previous observational studies have found an association between inflammatory bowel disease (IBD) and psoriasis. Using the mendelian randomization (MR) approach, we aim to determine whether there was a causal IBD Methods We performed two-sample MR with genetic instruments identified for its main subtypes, Crohn’s (CD) ulcerative colitis (UC), from genome-wide study (GWAS) involving 25,042 cases diagnosis 34,915 controls. Summarized data psoriasis were obtained different GWAS which...
Previous studies have reported a potential association of polyunsaturated fatty acids (PUFAs) levels with allergic disease risk and the possible benefit PUFAs supplementation on prevention. This study was performed to estimate genetic between diseases using method both univariable multivariable two-sample Mendelian randomization (MR).As indicators levels, we included omega-3, omega-6, docosahexaenoic acid (DHA), eicosapentaenoic (EPA), linoleic (LA), ratio omega-6 omega-3 (omega-6:3)....
Abstract Previous evidence has suggested that childhood sunburn could be a risk factor for cutaneous malignant melanoma (MM) and non-melanoma skin cancer (NMSC). However, existing observational studies not reveal the causal associations genetically. This study aimed to investigate whether there was genetic relationship between cancers. Univariable Mendelian randomization (MR) Causal Analysis Using Summary Effect analysis carried out estimates evaluation horizontal pleiotropy. Multivariable...
Despite advances in cancer biomarkers and targeted therapies, early diagnosis treatment of inflammatory skin diseases remain challenging. This study aims to identify circulating proteins causally linked diseases, including acne, atopic dermatitis, systemic lupus erythematosus, psoriasis, rosacea, urticaria, through a Mendelian randomization (MR) framework. A large-scale MR analysis was performed assess the causal effects thousands plasma on common diseases. Additional methods, Steiger...
This study aimed at exploring the potential causal effects of leisure sedentary behavior (LSB) on common types arthritis. Two-sample Mendelian randomization (MR), including both univariable MR (UVMR) and multivariable (MVMR) analysis, was performed to explore LSB risk several arthritis, osteoarthritis, rheumatoid arthritis (RA), psoriatic (PsA). Genetic variants from genome-wide association studies (GWAS) LSBs for time spent television watching, computer use, driving were obtained UK...
The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson's disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance imaging data were collected from 47 patients early-stage, PD 50 HCs. Functional analyzed the integrity, network, edge levels; UPDRS-III, MMSE, MOCA, HAMA, HAMD scores, reflecting symptoms PD, for further regression analysis. Compared age-matched HCs,...
To explore whether there is a genetic causal relationship between sleep traits and the risk of autoimmune arthritis (AA).
Aseptic prosthetic loosening is one of the main factors causing poor prognosis limb function after joint replacement and requires troublesome revisional surgery. It featured by wear particle-induced periprosthetic osteolysis mediated excessive osteoclasts activated in inflammatory cell context. Some natural compounds show antiosteoclast traits with high cost-efficiency few side effects. Tussilagone (TUS), which functional extract from Tussilago farfara generally used for relieving cough,...
Objective: To explore the prognostic value of expression genes encoding structural maintenance chromosomes (SMCs) in human sarcoma.Results: We found that levels SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher most tumors compared to normal tissues, especially sarcoma.According Cancer Cell Line Encyclopedia (CCLE), are also highly expressed sarcoma cell lines.Results Gene Expression Profiling Interactive Analysis (GEPIA) indicated high SMC1A was significantly related poor overall...
In December 2019, a cluster of coronavirus Disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. The present study was conducted to report the clinical characteristics 201 COVID-19 patients Changsha, China, city outside Wuhan. All with confirmed were admitted First Hospital Changsha City, designated hospital for assigned by City Government. and epidemiological characteristics, data laboratory, radiological picture, treatment, outcomes records collected using electronic medical...
Abstract Background While numerous allergy-related biomarkers and targeted treatment strategies have been developed employed, there are still signifcant limitations challenges in the early diagnosis for allegic diseases. Our study aims to identify circulating proteins causally associated with allergic disease-related traits through Mendelian randomization (MR)-based analytical framework. Methods Large-scale cis-MR was employed estimate effects of thousands plasma on five main Additional...
The potential effects of insulin therapy on osteoarthritis (OA) risk are poorly understood. This study aimed to explore the causal relationship between and OA.
Observational research reported the underlying correlation of metabolic syndrome (MetS) and its components with rotator cuff tendinopathy (RCT), but their causality remained unclear. This study aimed to investigate whether genetically predicted MetS was related risk RCT.Both univariable multivariable Mendelian randomization (MR) analysis applied using summary-level data from most comprehensive genome-wide association studies estimate associations component RCT, inverse variance weighted...
Abstract This study addresses the diagnostic and therapeutic challenges in malignant melanoma (MM) non-melanoma skin cancers (NMSC). We aim to identify circulating proteins causally linked MM NMSC traits using a multicenter Mendelian randomization (MR) framework. utilized large-scale cis-MR estimate impact of numerous plasma on MM, NMSC, squamous cell carcinoma (SCC), basal (BCC). To ensure robustness, additional analyses like MR Steiger Bayesian colocalization are conducted, followed by...
Several studies demonstrated potential associations between the telomere length (TL) in leukocytes and psoriasis or psoriatic arthritis (PsA). This study aimed to investigate whether there was causal genetic relationship TL diseases bidirectionally.
Abstract Background Hydrogen peroxide has been widely used in Orthopaedics including Orthopaedic oncology, trauma and joint surgeries. However, we encountered an oxygen embolism myoglobinuria after hydrogen was to irrigate a septic hip arthroscopically. Case presentation A 61-year-old male patient with right arthritis underwent arthroscopic washout debridement. During the operation, surgeon 100 ml of 3% cavity. Two minutes irrigation, there transient decrease saturation, heart rate blood...
Background: Post-stroke depression (PSD) is one of the most common complications after stroke, which seriously affects patients' recovery outcome. Although vascular has been extensively studied, relationship between cerebral artery stenosis and PSD not clarified so far. Methods: Two hundred ninety-eight patients with ischemic stroke (72 women, 226 men) computed tomography angiography (CTA) or magnetic resonance (MRA) were included in this study. Cerebral ≥50% was used as cut-off value. The...