A5035613285- Cancer-related Molecular Pathways
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Sarcoma Diagnosis and Treatment
- Radioactivity and Radon Measurements
- Land Use and Ecosystem Services
- Ultrasound and Hyperthermia Applications
- Semiconductor Lasers and Optical Devices
- Soil and Land Suitability Analysis
- Optical Network Technologies
- Radiation Therapy and Dosimetry
- 3D Modeling in Geospatial Applications
- Ultrasound Imaging and Elastography
- Adrenal and Paraganglionic Tumors
- Acute Lymphoblastic Leukemia research
- HER2/EGFR in Cancer Research
- Urban Planning and Valuation
- Advanced Optical Network Technologies
- Multiple Myeloma Research and Treatments
- Breast Lesions and Carcinomas
- RNA modifications and cancer
- Respiratory Support and Mechanisms
- Breast Implant and Reconstruction
- Neurosurgical Procedures and Complications
- Medical Imaging Techniques and Applications
Maria Eleonora Hospital
2021
Istituto Superiore di Sanità
1989-2020
University of Naples Federico II
2015
Santissima Trinità
2013
Università Cattolica del Sacro Cuore
1996-2009
Istituto Nazionale di Fisica Nucleare
2007
European Institute of Oncology
2003-2005
University of Milan
2005
To assess whether the risk for nonsentinel node metastases may be predicted, thus sparing a subgroup of patients with breast carcinoma and positive sentinel lymph (SLN) biopsy completion axillary dissection (ALND).The SLN is only involved in majority undergoing ALND biopsy. A model to predict status nodes could help tailor surgical therapy those most likely benefit from ALND.All 1228 were reviewed histologically reclassified according current TNM classification malignant tumors as bearing...
Abstract. Today it is evident that there are many contrasting demands on our landscape (e.g. food security, more sustainable agriculture, higher income in rural areas, etc.) as well land degradation problems. It has been proved providing operational answers to these and problems extremely difficult. Here we aim demonstrate a spatial decision support system based geospatial cyberinfrastructure (GCI) can address all of the above, so producing smart for supporting making forestry, urban...
Abstract p63 is a p53 ‐related gene mapping to 3q28 that codes for multiple mRNA transcripts with ( TA‐p63 ) or without (Δ N‐p63 transactivating effects on genes promote cell differentiation and apoptosis. We analysed alterations by immunohistochemistry, quantitative real‐time RT‐PCR FISH in series of 45 follicular lymphomas (FL). None the tumours showed immunoreactivity p40 antibody, which recognizes only truncated isoforms p63, Δ expression. Immunoreactivity 4A4 both isoforms, was found 5...
The changes induced on respiratory mechanics and tracheobronchial aspirate fluid (TAF) cytology by dexamethasone courses started at two different postnatal ages in preterm infants risk of chronic lung disease (CLD) were reported this clinical trial designed phases. first phase the study included 20 neonates with birth weight ≤1,250 g gestational age ≤32 weeks, who oxygen ventilator dependent 10th day life. They randomly assigned to moderately early (MED) group or control group. second same...
Abstract Purpose: To analyze the prevalence and clinical relevance of cyclin D3 abnormalities in laryngeal squamous cell carcinoma (LSCC). Experimental Design: Cyclin immunoreactivity was evaluated 223 formalin-fixed paraffin-embedded samples LSCC patients with a mean follow-up 62.8 ± 43.2 months. The occurrence extra signals analyzed by fluorescence situ hybridization 47 randomly selected cases collected tissue microarray. D1 had been previously investigated 133 cases. Results: gene were...
Summary. Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti‐CD34 and CD105 monoclonal antibodies (Abs), found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients preclinical model non‐obese diabetice/severe combined immunodeficient mice transplanted with HCL line Bonna‐12. The anti‐CD105 Ab significantly more sensitive than identifying blood vessels. BM tumour burden decreased treated interferon‐α, but mean value MVD remained...
Abstract An abnormal expression of cyclin D3, a key regulator the cell cycle, has been documented in variety human malignancies, and D3 gene, mapping to 6p21, may be deregulated plasma myeloma non‐Hodgkin's lymphoma as result t(6;14)(p21.1;q32.3) translocation and/or gene amplification. In current study, we for first time investigated by immunohistochemistry fluorescence situ hybridization (FISH) prevalence abnormalities follicular lymphomas (FLs), comparing results with traditional...
Immunohistochemistry is the most widely used approach in diagnosis of mantle cell lymphoma (MCL). However, its reliability may be hampered by several technical reasons, necessitating use alternative techniques such as identification t(11;14)(q13;q32) translocation to characterize lesions. The authors compared two monoclonal antibodies (DCS-6 and SP4) for assessing cyclin D1 immunoreactivity a series 22 MCLs. Their results documented that SP4, novel rabbit antibody, more effective than mouse...
High Intensity Focused Ultrasound (HIFU) is a noninvasive treatment for therapeutic applications, in particular the of either benign or malignant tumor lesions. HIFU based on power focused ultrasound beam to locally heat biological tissues over necrotic level with minimal impact surrounding tissues. Therapies are becoming widely spread panorama options offered by Health Care System. Consequently, there an ever increasing need standardise quality assurance protocols and develop computational...
New technologies in cancer radiotherapy need a more accurate computation of the dose delivered radiotherapeutical treatment plan, and it is important to integrate sophisticated mathematical models advanced computing knowledge into planning (TP) process. We present some results about using Monte Carlo (MC) codes calculation for planning. A distributed resource located Technologies Health Department Italian National Institute (ISS) along with other computer facilities (CASPUR -...
This study aims at evaluating the effects of different lung densities on dose distribution after irradiation field sizes, by comparing experimental measurements, GEANT4 Monte Carlo (MC) simulations and two TPS calculation algorithms ad hoc phantoms. Irradiations were performed with a Varian Clinac 2100 C/D nominal energy 6 MV. Dosimetric measurements obtained radiochromic films. A model based MC code was developed to simulate both accelerator Results show an acceptable agreement between in...
Abstract. Today it is evident that there are many contrasting demands on our landscape (e.g. food security, more sustainable agriculture, higher income in rural areas, etc.) but also land degradation problems. It has been proved providing operational answers to these and problems extremely difficult. Here we aim demonstrate a Spatial Decision Support System based geospatial cyber-infrastructure (GCI) can embody all of the above, so producing smart system for supporting decision making...
Pheochromocytoma is a rare adrenal tumor characterized by the secretion of catecholamines and vasoactive peptides. It can cause catecholaminergic storm lead to acute coronary syndromes. We present case 53-year-old man, without any medical history, who arrived hospital following spinal trauma due fall. He presents back retrosternal pain, with clinical status pulmonary edema, sinus tachycardia left bundle branch block, ventricular apical ballooning depressed systolic function. Blood tests show...
Total (and differential) cell count of BAL fluids was performed by two different automatic analyzers. While a good correlation obtained between the microscope counts and those with analyzers, no in case differential counts.
The Italian National Institute of Health (Istituto Superiore di Sanità ‒ ISS) has a long experience activities concerning protection from radon exposure (measuring techniques, surveys in dwellings and other environments, public information, training courses, epidemiological studies risk evaluation, etc.) with the first dating back to eighties. On basis this expertise, ISS also contributed policies regulations, particular development Radon Action Plan (INRAP) 2002 its coordination following...