A5071395715- Spaceflight effects on biology
- Heart Rate Variability and Autonomic Control
- Thermoregulation and physiological responses
- High Altitude and Hypoxia
- Non-Invasive Vital Sign Monitoring
- Climate Change and Health Impacts
- Thermal Regulation in Medicine
- Infrared Thermography in Medicine
- Neuroscience of respiration and sleep
- Cardiovascular and exercise physiology
- Cardiovascular and Diving-Related Complications
- Sports Performance and Training
- Hemodynamic Monitoring and Therapy
- Vitamin D Research Studies
- Body Composition Measurement Techniques
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Syncope and Autonomic Disorders
- Obesity, Physical Activity, Diet
- Ergonomics and Musculoskeletal Disorders
- Advanced Glycation End Products research
- Heat Transfer and Optimization
- Exercise and Physiological Responses
- Gene Regulatory Network Analysis
- Neurobiology and Insect Physiology Research
Charité - Universitätsmedizin Berlin
2016-2025
University Hospital Frankfurt
2024
Goethe University Frankfurt
2024
Humboldt-Universität zu Berlin
2017-2022
Freie Universität Berlin
2017-2022
GP Forschungsgruppe
2013
MSB Medical School Berlin
2013
Unfallkrankenhaus Berlin
2008
University of Regensburg
2007
Humans' core body temperature (CBT) is strictly controlled within a narrow range. Various studies dealt with the impact of physical activity, clothing, and environmental factors on CBT regulation under terrestrial conditions. However, effects weightlessness human thermoregulation are not well understood. Specifically, studies, investigating long-duration spaceflight at rest during exercise clearly lacking. We here show that rises higher faster in space than Earth. Moreover, we observed for...
Continuous recordings of core body temperature (CBT) are a well-established approach in describing circadian rhythms. Given the discomfort invasive CBT measurement techniques, use skin has been proposed as surrogate. More recently, we heat-flux (the so-called Double Sensor) for monitoring CBT. Studies investigating reliability over 24-hour period, well comparisons with recordings, however lacking. The first aim study was therefore to compare rectal, skin, and rhythm. In addition, assess...
Accurate blood pressure (BP) measurement is crucial for the diagnosis, risk assessment, treatment decision-making, and monitoring of cardiovascular diseases. Unfortunately, cuff-based BP measurements suffer from inaccuracies discomfort. This study first to access feasibility machine learning-based estimation using impedance cardiography (ICG) data. We analyzed ICG data 71 young healthy adults. Nine different learning algorithms were evaluated their performance against quality controlled,...
Antarctic residence holds many challenges to human physiology, like increased psycho-social tension and altered circadian rhythm, known influence sleep. We assessed changes in sleep patterns during 13 months of overwintering at the German Stations Neumayer II III from 2008 2014, with focus on gender, as previous investigations were inconclusive regarding gender-based differences or had only included men.Time bed, time, efficiency, number arousals, latency, onset, offset, physical activity...
Firefighters face a high-risk potential, thus their psychological ability to cope with critical or traumatic events is crucial characteristic. This study examines correlations between cardiac autonomic modulation, risk-taking behavior, and resilience in professional firefighters. Twenty male firefighters underwent 20 min beat-to-beat heart rate (HR) monitoring at baseline the morning upon awakening, then before, during after realistic deployment container, systematically set on fire....
Background: Precisely measuring the core body temperature during targeted management after return of spontaneous circulation is mandatory, as deviations from recommended might result in side effects such electrolyte imbalances or infections. However, previous methods are invasive and lack easy handling. A disposable, non-invasive sensor using heat flux approach (Double Sensor), was tested against standard method: an esophagus thermometer. Methods: The placed on forehead adult patients ( n =...
Head-down-tilt bed rest (HDT) mimics the changes in hemodynamics and autonomic cardiovascular control induced by weightlessness. However, time course reciprocal interplay of these adaptations, effective exercise protocol as a countermeasure need further clarification. The overarching aim this work (as part European Space Agency sponsored long-term study) was therefore to evaluate during prolonged HDT assess whether short-duration/high-intensity could mitigate effects. A total n=23 healthy,...
Abstract Nocturnal blood pressure (BP) shows the highest predictive power for cardiovascular events. However, there is a poor reproducibility of personalized dipping patterns in single individuals. We hypothesize that changes body position during sleep cause variations hydrostatic pressure,leading to incorrect BP values and classifications. 26 subjects aged 18–30 years, as well 25 participants 50 years older underwent ambulatory measurements on left arm, determination difference between cuff...
Purpose Humans in Antarctica face different environmental challenges, such as low ultra-violet radiation, which is crucial for vitamin D production humans. Therefore we assessed changes 25-OH-vitamin serum concentration during 13 months of overwintering at the German Stations Neumayer II and III (2007–2012). We hypothesized that (i) would significantly decrease, (ii) be affected by age, gender, baseline (i.e. pre-overwintering) fat mass, concentration, station residence, (iii) our results...
The use of daytime napping as a countermeasure in sleep disturbances has been recommended but its physiological evaluation at high altitude is limited.
Cardiovascular deconditioning occurs in astronauts during microgravity exposure, and may lead to post-flight orthostatic intolerance, which is more prevalent women than men. In-termittent artificial gravity a potential countermeasure, can effectively train the car-diovascular mechanisms responsible for maintaining integrity. Since cardiovascular responses differ between men gravitational challenges, information regarding gender specific intermittent exposure plays crucial role countermeasure...
Occipital stimulation in a small group of refractory chronic migraine and cluster headache patients has been suggested as novel therapeutic approach with promising results. In an earlier study we have shown that drug-induced block the greater occipital nerve (GON) inhibits nociceptive blink reflex (nBR). Now, sought to examine effects low-frequency (3 Hz) short-time GON on trigeminal system. We recorded nBR responses before after 34 healthy subjects. Selectivity was confirmed by eliciting...
Abstract Introduction: Optimal neuroendocrine responses, particularly noradrenergic are critical during hypergravity (+ Gz) exposure. Peripheral skin cooling (PSC) has the potential to enhance function, which could improve + Gz resiliency and may also affect leukocyte hematologic factors. We predicted that PSC would augment cumulative stress index (CGSI) neuroendocrine, activity compared controls, CGSI shift a dependency in controls. Methods 18 men cross-over design underwent graded profile....
Objective: Accurate blood pressure (BP) measurement is crucial for the diagnosis, risk assessment, treatment decision-making, and monitoring of cardiovascular diseases. Unfortunately, gold-standard, cuff-based BP suffer from inaccuracies discomfort. As a result, continuous, cuff-less, non-invasive assessment methods are merging as promising alternatives. This study first to comprehensively assess impedance cardiography (ICG) Machine Learning enabled measurement. Methods: We analysed ICG data...
Background and Objective: The assessment of nocturnal blood pressure (BP) is central in evaluating monitoring cardiovascular health. However, the determination dipping patterns has shown poor reproducibility. This possibly caused by influences such as changes body position during sleep resulting variations hydrostatic pressure. study aims to investigate impact on BP assess its clinical relevance. Methods: 26 subjects aged 18 30 years, well 25 participants 50 years older underwent...