A5040421226- Diet and metabolism studies
- Cardiovascular and exercise physiology
- High Altitude and Hypoxia
- Nutrition, Genetics, and Disease
- Adipose Tissue and Metabolism
- Multiple Sclerosis Research Studies
- Dietary Effects on Health
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Viral Infections and Vectors
- Circadian rhythm and melatonin
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Tea Polyphenols and Effects
- Muscle metabolism and nutrition
- Botulinum Toxin and Related Neurological Disorders
- Reproductive System and Pregnancy
- Ion Transport and Channel Regulation
- Acute Ischemic Stroke Management
- Viral Infections and Outbreaks Research
- Diabetes and associated disorders
- Pregnancy and preeclampsia studies
- Aortic Disease and Treatment Approaches
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sleep and Wakefulness Research
Charité - Universitätsmedizin Berlin
2011-2023
Max Delbrück Center
2015-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2015-2018
Lars Research Institute
2017-2018
MSB Medical School Berlin
2016
Institut Kurz
2015
University of Bonn
2015
German Centre for Cardiovascular Research
2015
Australian Institute of Tropical Health and Medicine
2011
Abbott (Germany)
2011
Objective— Soluble fms-like tyrosine kinase 1 (sFlt1) is involved in the pathophysiology of preeclampsia and coronary artery disease. Because sFlt1 has a heparin-binding site, we investigated whether or not heparin releases from extracellular matrix. Methods Results— We measured before after administration 135 patients undergoing angiography, percutanous intervention, both. was increased directly (from 254 to 13 440 pg/mL) returned baseline within 10 hours. Umbilical veins endothelial cells...
Background: Physical activity might attenuate inflammation and neurodegeneration in multiple sclerosis (MS). Erythropoietin, which is produced upon exposure to hypoxia, thought act as a neuroprotective agent MS. Therefore, we studied the effects of intermittent hypoxic training on energy expenditure, maximal workload, serum erythropoietin, immunophenotype focusing regulatory IL-17A-producing T cells. Methods: We assigned 34 relapsing-remitting MS patients within randomized, single blind,...
The evidence that physical exercise lowers metabolic and cardiovascular risk is undisputed. Normobaric hypoxia training has been introduced to facilitate the effects of exercise. We tested hypothesis augments exercise-related effects. randomized 23 men with metabolic-syndrome single-blinded at normoxia (FiO2 21%) or 15%). Six weeks endurance on a treadmill, 3 days per week, over 60 min 60% VO2 max was required. study included following: (1) phenotyping by indirect calorimetry adipose muscle...
The use of daytime napping as a countermeasure in sleep disturbances has been recommended but its physiological evaluation at high altitude is limited.
Spinal cord ischaemia (SCI) remains the most devastating complication after thoraco-abdominal aortic aneurysm (TAAA) repair. Its early detection is crucial if therapeutic interventions are to be successful. Cerebrospinal fluid (CSF) readily available and accessible microdialysis (MD) capable of detecting metabolites involved in SCI [i.e. lactate, pyruvate, lactate/pyruvate ratio (LPR), glucose glycerol] real time. Our aim was evaluate feasibility CSF MD for real-time metabolites.In a...
Each year in March, adherents of the Bahá’í faith abstain from eating and drinking sunrise to sunset for 19 days. Thus, fasting (BF) can be considered as a form daytime dry fasting. We investigated whether BF decreased energy expenditure after meal it improved anthropometric measures systemic tissue-level metabolic parameters. This was self-controlled cohort study with 11 healthy men. measured parameters, markers venous blood pre- postprandial metabolism at (indirect calorimetry) tissue...
Each year in March, adherents of the Bahá’í faith abstain from eating and drinking sunrise to sunset for 19 days. Thus, fasting (BF) can be considered as a form daytime dry fasting. We tested if BF decreases energy expenditure after meal improves anthropometric measures, systemic tissue-level metabolic parameters. This was self-controlled cohort study with 11 healthy men. measured parameters, markers venous blood, pre- postprandial metabolism at (indirect...
(1) Background: Insulin resistance (IR) is a characteristic pathophysiologic feature in heart failure (HF). We tested the hypothesis that skeletal muscle metabolism differently impaired patients with reduced (HFrEF) vs. preserved (HFpEF) ejection fraction. (2) Methods: carbohydrate and lipid was studied situ by intramuscular microdialysis HFrEF (59 ± 14y, NYHA I-III) HFpEF (65 10y, I-II) healthy subjects of similar age during oral glucose load (oGL); (3) Results: There were no difference...
Background: Assessing detailed metabolism in exercising persons minute-to-minute has not been possible. We developed a “drop-of-blood” platform to fulfill that need. Our study aimed only demonstrate the utility of our methodology, but also give insights into unknown mechanisms and new directions. Methods: platform, based on gas chromatography mass spectrometry, assess from blood-drop. first observed single volunteer who ran 13 km 61 min. particularly monitored relative perceived exertion...
Objective: High salt intake is a potential risk factor for obesity independent of energy intake, though underlying mechanisms remain unclear. Excessive body fat accumulation caused by positive balance over an extended period time. Food causes postprandial increase in expenditure. This effect represents approximately 10% the total ingested 24h. A decrease diet-induced thermogenesis (DIT) contributes to and weight gain The present study investigated 14-day high on DIT healthy men. Methods: We...
High salt intake is a potential risk factor for obesity independent of energy intake, though underlying mechanisms remain unclear. Diet-induced thermogenesis (DIT) accounts about 10% total expenditure. We hypothesized that high decreases DIT in healthy volunteers. enrolled 40 subjects (sex ratio 1:1) randomized, double-blind, placebo-controlled, parallel-group study (NCT03024567). They received either 6 g or placebo daily capsules over 14 days on top their habitual diet. Before and after the...