A5014334468- Inflammasome and immune disorders
- Inflammation biomarkers and pathways
- Autoimmune and Inflammatory Disorders Research
- Sphingolipid Metabolism and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Natural product bioactivities and synthesis
First Affiliated Hospital of Bengbu Medical College
2023-2024
Bengbu Medical College
2023-2024
Wenzhou Medical University
2020
Abstract: Obesity-induced cardiomyopathy involves chronic and sustained inflammation. The toll-like receptor 4 (TLR4) signaling pathway can associate innate immunity with obesity. Myeloid differentiation primary response 88 (MyD88), an indispensable downstream adaptor molecule of TLR4, has been reported to mediate obesity complications. However, whether inhibition MyD88 mitigate obesity-induced heart injury remains unclear. LM8, a new inhibitor, exhibits prominent anti-inflammatory activity...
Abstract Aberrant activation of the NLRP3 inflammasome contributes to evolution diverse inflammatory diseases. Inhibition has been proven be an effective treatment strategy for NLRP3‐driven This study revealed that multiple natural diterpenes from Isodon plants can inhibit inflammasome, among which Rosthornin B (Ros B) exhibited best inhibitory effect, with IC 50 0.39 μM. Further Ros directly interacts NLRP3, thereby restraining NEK7‐NLRP3 interaction and inhibiting assembly activation....
To investigate the effect of Isodopharicin C (Iso C), a traditional Chinese herbal medicine extract, on NLRP3 inflammasome activation and lipopolysaccharide (LPS)-induced septic shock in mice.Murine bone marrow-derived macrophages (BMDM) human monocytic THP-1 cells were stimulated with LPS before treatment different agonists to activate canonical inflammasomes. The non-canonical inflammasomes activated by intracellular transfection, AIM2 poly A: T. cleavage caspase-1 induced was measured...