A5020733395- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Glycogen Storage Diseases and Myoclonus
- Neonatal and fetal brain pathology
- Cerebrovascular and genetic disorders
- Pharmacological Effects and Toxicity Studies
- Growth Hormone and Insulin-like Growth Factors
- Organ Donation and Transplantation
- Retinal Development and Disorders
- Photoacoustic and Ultrasonic Imaging
- Peripheral Neuropathies and Disorders
- Ion Transport and Channel Regulation
- EEG and Brain-Computer Interfaces
- Ophthalmology and Eye Disorders
- Hereditary Neurological Disorders
- Neurological Complications and Syndromes
- Multiple Sclerosis Research Studies
- Axon Guidance and Neuronal Signaling
- Polyomavirus and related diseases
- Family and Patient Care in Intensive Care Units
- Neurobiology of Language and Bilingualism
- Cerebrospinal fluid and hydrocephalus
- RNA regulation and disease
- Hallucinations in medical conditions
Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
2019
University Hospital of Geneva
2007-2017
Boston Children's Hospital
2014
University of Lausanne
2014
Harris Health System
2014
Ben Taub Hospital
2014
Texas Woman's University
2014
Montagu Hospital
2007
World Health Organization - Pakistan
2003
Guy's Hospital
2001
Summary: Purpose: Epilepsy is a relatively frequent disease in children, with considerable impact on cognitive and social life. Successful epilepsy surgery depends unambiguous focus identification requires comprehensive presurgical workup, including several neuroimaging techniques [magnetic resonance imaging, positron emission tomography (PET), single‐photon computed (SPECT)]. These may be difficult to apply younger or developmentally delayed children both, requiring sedation, hence,...
Abstract Extensive intracranial calcifications and leukoencephalopathy are seen in both Coats plus with cysts (LCC; Labrune syndrome). syndrome is additionally characterized by the presence of bilateral retinal telangiectasia exudates while LCC shows progressive formation parenchymal brain cysts. Despite these apparently distinguishing features, recent evidence suggests that represent same clinical entity a common primary pathogenesis involving small vessel obliterative microangiopathy....
In this case report we assess the occurrence of cortical malformations in children with early infantile epilepsy associated variants gene protocadherin 19 ( PCDH ). We describe clinical course, and electrographic, imaging, genetic, neuropathological features a cohort female pharmacoresistant epilepsy. All five (mean age 10y) had an onset during infancy predominance fever sensitive seizures occurring clusters. Cognitive impairment was noted four out patients. Radiological evidence present all...
The estimation of the global burden measles is challenging in absence reliable and comparable surveillance systems worldwide. A static model described that enables morbidity, mortality, disability for year 2000 on basis country-specific information (i.e., demographic profile, vaccine coverage, estimates case-fatality ratios). This approach estimated a incidence 39.9 million cases, 777,000 deaths, 28 disability-adjusted life years. World Health Organization regions Africa Southeast Asia had...
ABSTRACT Multiple structural and functional imaging modalities are available to localize the epileptogenic focus. In pre‐surgical evaluation of children with pharmacoresistant epilepsy, investigations maximum yield should be considered in order reduce complexity workup. Objective To determine extent which PET, ictal/interictal SPECT its co‐registration patient's MRI contributes correct localization focus, surgical intervention post outcome paediatric patients. Methods The study population...
The number of patients waiting for organ transplantation continues to grow, while organs are donated by very few the thousands potential donors who die every year. authors' neurosurgical intensive care unit (NICU) has worked closely with coordinators from local procurement organization (OPO) many years. In this study, authors analyze donation rates in NICU and discuss factors that may be important maximizing these rates.All referrals OPO 1996 1999 were analyzed. Of 180 referrals, 98 found...
Stroke-like presentation in Lyme neuroborreliosis is rare the pediatric age group. We report a previously healthy 12-year-old boy who presented with acute left hemiparesis and meningeal signs. Neuroimaging failed to reveal any cerebral infarction but demonstrated multifocal vasculitis involving small, medium large-sized vessels affecting both anterior posterior circulation. Concentric contrast enhancement of basilar artery was also observed. Further investigations laboratory findings were...
Patient death in intensive care units (ICUs) can be sudden and unexpected, leading to emotionally charged situations life-changing circumstances for family members. This study aimed ascertain ICU registered nurses' (RNs') current practice beliefs about bereavement care, their role support, interest education related bereavement. Results from nurses working on that received support program training were compared with results control units. A posttest-only survey design using a convenience...
Progressive myoclonic epilepsies are rare neurodegenerative diseases with a wide spectrum of clinical presentations and genetic heterogeneity that render their diagnosis perplexing. Discovering new imputable genes has been an ongoing process in recent years. We present two pediatric cases progressive epilepsy SERPINI1 pathogenic variants lead to severe presentation; we highlight the importance including this gene, previously known as causing adult-onset dementia-epilepsy syndrome, work-up...
Abstract Multifocal motor neuropathy (MMN) and anti‐myelin‐associated glycoprotein (anti‐ MAG )‐associated are clinically electrophysiologically distinct entities. We describe a patient with characteristic features of both neuropathies, raising the possibility an overlap syndrome. A 49‐year‐old reported history slowly progressive predominantly distal tetraparesis, mild sensory deficits. Nerve conduction studies demonstrated persistent blocks outside compression sites, typical MMN. Laboratory...
Abstract Ictal vocalizations in the form of both articulate speech and non‐speech have been described focal epilepsies, with seizures originating mainly from frontal temporal lobe, however, this phenomenon has not generalized epilepsies. We report case an adolescent boy juvenile‐onset epilepsy who presented ictal “ovine vocalizations” (resembling bleating sheep). The EEG revealed a clear correlate time‐locked spikes polyspike discharges. 3T cerebral MRI ruled out any lesion. is currently...
The veterinary care of cats and dogs is increasingly embracing innovations first applied to human health, including an increased emphasis on preventative precision medicine. Large scale population biobanks have advanced research in these areas; however, few been established MARS PETCARE BIOBANK™ (MPB) a prospective study that aims build longitudinal bank biological samples, with paired medical lifestyle data, from 20,000 initially healthy (10,000 / species), recruited through hospitals over...
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<h3>Introduction</h3> Human trafficking is the practice of illegally transporting a person from one area or country to another, often for purposes forced physical labour sexual exploitation. In UK, 2118 cases and modern slavery minors were reported in 2017. We describe case 14 year old Vietnamese boy who was trafficked UK had primary pulmonary tuberculosis. There missed opportunities diagnosis treatment, leading several members his foster family developing <h3>Case description</h3> This...
Objective: To assess the diVerences between headache and nonheadache groups in benign intracranial hypertension (BIH).Design/setting: Data obtained from a retrospective audit study encompassing epidemiology, aetiology, symptomatology, treatment visual outcome of BIH population currently followed up at Guys Hospital.Results: See table.Within paediatric group, significant proportion present without headaches (7/16).The atypical presentation group were predominantly male showed significantly...