A5052943964- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Nutrition, Genetics, and Disease
- T-cell and B-cell Immunology
- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Histone Deacetylase Inhibitors Research
- Phytochemicals and Antioxidant Activities
- Cell death mechanisms and regulation
- Antioxidant Activity and Oxidative Stress
- Tannin, Tannase and Anticancer Activities
- Edible Oils Quality and Analysis
- Biochemical Analysis and Sensing Techniques
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Biochemical and Molecular Research
- Genomics, phytochemicals, and oxidative stress
- Crystallization and Solubility Studies
- Adrenal Hormones and Disorders
- S100 Proteins and Annexins
- Atherosclerosis and Cardiovascular Diseases
- HER2/EGFR in Cancer Research
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Immunotherapy and Immune Responses
Universität Innsbruck
2020-2023
Innsbruck Medical University
2017-2021
Universitat de Miguel Hernández d'Elx
2011-2014
In this work, a global F oodomics strategy has been applied to study the antiproliferative effect of dietary polyphenols from rosemary on two human leukemia lines, one showing drug‐sensitive phenotype ( K 562), and another exhibiting drug‐resistant 562/ R ). To aim, whole‐transcriptome microarray together with an MS ‐based nontargeted analytical approach (via CE ‐ TOF UPLC ) have employed carry out transcriptomics metabolomics analyses, respectively. Functional enrichment analysis was done...
Abstract A group of organotin(IV) complexes were prepared: [SnCy 3 (DMNI)] ( 1 ), (BZDO)] 2 (DMFU)] and [SnPh (BZDO) ] 4 for which DMNIH=2,6‐dimethoxynicotinic acid, BZDOH=1,4‐benzodioxane‐6‐carboxylic DMFUH=2,5‐dimethyl‐3‐furoic acid. The cytotoxic activities compounds – tested against pancreatic carcinoma (PANC‐1), erythroleukemia (K562), two glioblastoma multiform (U87 LN‐229) human cell lines; they show very high antiproliferative activity, with IC 50 values in the 150–700 n M range...
Activation of the immune system increases systemic adrenal-derived glucocorticoid (GC) levels which downregulate response as part a negative feedback loop. While CD4+ T cells are essential target affected by GC, it is not known whether these hormones exert their major effects on helper cells, CD4+Foxp3+ regulatory (Treg cells), or both. Here, we generated mice with specific deletion receptor (GR) in Foxp3+ Treg cells. Remarkably, while basal cell characteristics and vitro suppression...
Selumetinib (AZD6244, ARRY-142886) is a MEK1/2 inhibitor that has gained interest as an anti-tumour agent. We have determined the degree of sensitivity/resistance to in panel colorectal cancer cell lines using proliferation and soft agar assays. Sensitive underwent G1 arrest, whereas had no effect on cycle resistant cells. Some showed high levels ERK1/2 phosphorylation absence serum. inhibited RSK AKT both sensitive Furthermore, mutations KRAS, BRAF, or PIK3CA were not clearly associated...
Glucocorticoids (GC) are essential regulators of T-cell development and function. Activation the immune system increases systemic adrenal-derived GC levels which downregulate activity as part a negative feedback control system. Increasing evidence shows, however, that can also be derived from extra-adrenal sources such thymus or intestine, thus providing local GC-mediated effects. The reportedly produces GC, but whether thymic epithelial cells thymocytes produce acting either in an autocrine...
Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mitochondrial apoptosis. Here, we aimed determine their prognostic value primary tumour samples from 92 BC patients. Our analysis identified high NOXA/PMAIP mRNA expression levels an independent marker for improved relapse-free survival (RFS) overall (OS)...
Abstract Background It has been reported that the histone deacetylase inhibitor (iHDAc) trichostatin A (TSA) induces an increase in MDR1 gene transcription (ABCB1). This result would compromise use of iHDACs combination with other cytotoxic agents are substrates P-glycoprotein (Pgp). also alternative promoters by ABCB1 and existence a translational control Pgp protein. Finally, is located genetic locus nested RUNDC3B complementary DNA strand, raising possibility expression could interfere...