A5102006773- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Circular RNAs in diseases
- Chromosomal and Genetic Variations
- Neuroscience and Neuropharmacology Research
- Neonatal Respiratory Health Research
- Ion channel regulation and function
- RNA Research and Splicing
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- interferon and immune responses
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Occupational and environmental lung diseases
- Mitochondrial Function and Pathology
- Cholesterol and Lipid Metabolism
- IL-33, ST2, and ILC Pathways
- HIV Research and Treatment
- Ferroptosis and cancer prognosis
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tendon Structure and Treatment
- Cancer-related gene regulation
- Neuroendocrine regulation and behavior
Wuhan University
2021-2025
Shanghai Sixth People's Hospital
2025
Shanghai Jiao Tong University
2025
China Medical University
2024
State Key Laboratory of Virology
2021-2022
Southwest Hospital
2020
Schizophrenia is a severe neuropsychiatric disorder affecting about 1% of individuals worldwide. Increased innate immune activation and neuronal apoptosis are common findings in schizophrenia. Interferon beta (IFN-β), an essential cytokine promoting regulating responses, causes vitro. However, the precise pathogenesis schizophrenia unknown. Recent studies indicate that domesticated endogenous retroviral envelope glycoprotein W family (HERV-W ENV, also called ERVWE1 or syncytin 1), derived...
Abstract Eukaryotic five-methylcytosine (m 5 C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown. In this study, functional m C sites are identified hepatitis B virus (HBV) mRNA. The modification at nt 1291 not only indispensable for Aly/REF export factor (ALYREF) recognition to promote mRNA HBx translation but also the inhibition RIG-I binding suppress interferon-β (IFN-β) production. Moreover, NOP2/Sun...
An increasing number of studies have begun considering human endogenous retroviruses (HERVs) as potential pathogenic phenomena. Our previous research suggests that HERV-W Envelope (HERV-W ENV), a family envelope protein, is elevated in schizophrenia patients and contributes to the pathophysiology schizophrenia. The dopamine (DA) hypothesis cornerstone clinical practice related Here, we found concentration DA expression receptor D2 (DRD2) were significantly higher than healthy individuals....
Human endogenous retroviruses (HERVs) are remnants of ancestral germline infections by exogenous retroviruses. W family envelope gene (HERV-W env, also called ERVWE1), located on chromosome 7q21-22, encodes an glycoprotein from the HERV-W family. Mounting evidence suggests that aberrant expression ERVWE1 involves etiology schizophrenia. Moreover, genetic and morphological studies indicate dendritic spine deficits may contribute to onset Here, we reported changed density morphology through...
Human endogenous retroviruses (HERVs) are remnants of retroviral infections in human germline cells from millions years ago. Among these, ERVW-1 (also known as HERV-W-ENV, ERVWE1, or ENVW) encodes the envelope protein HERV-W family, which contributes to pathophysiology schizophrenia. Additionally, neuropathological studies have revealed cell death and disruption iron homeostasis brains individuals with Here, our bioinformatics analysis showed that differentially expressed genes prefrontal...
HERVs (Human endogenous retroviruses) are remnants of ancient exogenous retroviruses that have integrated into the human genome, particularly in germ-line cells. Among these, envelope protein gene HERV-W env W family protein), located on chromosome 7 and primarily expressed placenta, has been closely linked to various neuropsychiatric disorders, including schizophrenia, as well autoimmune diseases cancer. Recent studies highlighted abnormal expression cytokines a key factor pathophysiology...
Abstract Knee arthrofibrosis, characterized by excessive matrix protein production and deposition, substantially impairs basic daily functions, causing considerable distress financial burden. However, the underlying pathomechanisms remain unclear. Here, we heterogeneous cell populations cellular pathways combination of flow cytometry single-cell RNA-seq analysis synovial tissues from six patients with or without knee arthrofibrosis. Increased macrophages fibroblasts were observed decreased...
Schizophrenia, a mental disorder, afflicts 1% of the worldwide population. The dysregulation homeostasis in endoplasmic reticulum (ER) has been implicated schizophrenia. Moreover, recent studies indicate that ER stress and unfolded protein response (UPR) are linked to this disorder. Our previous research verified endogenous retrovirus group W member 1 envelope (ERVW-1), risk factor for schizophrenia, is elevated individuals with Nevertheless, no literature available regarding underlying...
Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest that human endogenous retrovirus W family envelope (ERVWE1) is an influential risk factor for schizophrenia inversely correlates with 5-HT4 receptor To our knowledge, no data describes effect ERVWE1 on neuronal plasticity. N6-methyladenosine (m6A) regulates gene expression impacts Our research aims to systematically investigate effects through m6A modification...
The human endogenous retroviruses type W family envelope (HERV-W env) gene is located on chromosome 7q21-22. Our previous studies show that HERV-W env elevated in schizophrenia and can increase calcium influx. Additionally, the 5-HTergic system particularly 5-hydroxytryptamine (5-HT) receptors play a prominent role pathogenesis treatment of schizophrenia. receptor 4 (5-HT4R) agonist block channels. However, underlying relationship between 5-HT4R etiology has not been revealed. Here, we used...
Occupational crystalline silica (CS) particle exposure leads to silicosis. The burden of CS-associated disease remains high, and treatment options are limited due vague mechanisms. Here we show that pulmonary CD4
Schizophrenia afflicts 1% of the world population. Clinical studies suggest that schizophrenia patients may have an imbalance mitochondrial energy metabolism via inhibition complex I activity. Moreover, recent shown ERVWE1 is also a risk factor for schizophrenia. Nevertheless, there no available literature concerning relationship between deficits and in Identifying factors blood-based biomarkers provide new guidelines early interventions prevention programs.To address novel potential...
Abstract Background Increasingly studies highlight the crucial role of ancestral retrovirus envelope protein ERVWE1 in pathogenic mechanisms schizophrenia, a severe psychiatric disorder affecting approximately 1% global population. Recent also underscore significance circular RNAs (circRNAs), for neurogenesis and synaptogenesis, maintaining neuronal functions. However, precise relationship between circRNAs etiology schizophrenia remains elusive. Results This study observed elevated levels...
Bartter syndrome is a rare inherited disease caused by CLCNKB mutation, which results in inactivation of the chloride channel Kb protein. characterized extreme hypokalemia, hypochloremia, metabolic alkalosis, hyperrenin-induced angiotensinemia, hyperaldosteronemia, and normal blood pressure. We herein report case that manifested as vomiting, pressure, significant angiotensinemia. The patient, 5-month-old girl, carried two known heterozygous pathogenic mutations: c.88C > T (p.Arg30*), she...
<title>Abstract</title> Exposure to crystalline silica particle leads silicosis characterized as progressive fibrosis. Fibroblasts are described vital effector cells in fibrogenesis. Emerging studies identified immune sentinel role of fibroblasts chronic disease, while their immune-modulatory remained elusive. Herein, we confirmed that a conversion ILC2 ILC1 closely involved was mediated by activated fibroblast via IL-18. Mechanistically, Notch3 signaling mechanics-activated modulated IL-18...