A5101887940- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- interferon and immune responses
- Circular RNAs in diseases
- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Anesthesia and Pain Management
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Inflammasome and immune disorders
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Nitric Oxide and Endothelin Effects
- Anorectal Disease Treatments and Outcomes
- Clostridium difficile and Clostridium perfringens research
- Multiple Sclerosis Research Studies
- Pediatric Pain Management Techniques
- Pediatric health and respiratory diseases
- Celiac Disease Research and Management
- Amoebic Infections and Treatments
- Cardiac Fibrosis and Remodeling
Ningbo Medical Center Lihuili Hospital
2025
Ningbo University
2025
Affiliated Eye Hospital of Wenzhou Medical College
2023-2025
Wenzhou Medical University
2023-2025
Wuhan University
2022-2024
State Key Laboratory of Genetic Engineering
2019
Fudan University
2017-2019
Schizophrenia is a severe neuropsychiatric disorder affecting about 1% of individuals worldwide. Increased innate immune activation and neuronal apoptosis are common findings in schizophrenia. Interferon beta (IFN-β), an essential cytokine promoting regulating responses, causes vitro. However, the precise pathogenesis schizophrenia unknown. Recent studies indicate that domesticated endogenous retroviral envelope glycoprotein W family (HERV-W ENV, also called ERVWE1 or syncytin 1), derived...
An increasing number of studies have begun considering human endogenous retroviruses (HERVs) as potential pathogenic phenomena. Our previous research suggests that HERV-W Envelope (HERV-W ENV), a family envelope protein, is elevated in schizophrenia patients and contributes to the pathophysiology schizophrenia. The dopamine (DA) hypothesis cornerstone clinical practice related Here, we found concentration DA expression receptor D2 (DRD2) were significantly higher than healthy individuals....
Human endogenous retroviruses (HERVs) are remnants of ancestral germline infections by exogenous retroviruses. W family envelope gene (HERV-W env, also called ERVWE1), located on chromosome 7q21-22, encodes an glycoprotein from the HERV-W family. Mounting evidence suggests that aberrant expression ERVWE1 involves etiology schizophrenia. Moreover, genetic and morphological studies indicate dendritic spine deficits may contribute to onset Here, we reported changed density morphology through...
Disease-modifying therapies (DMTs) that prevent immune cell infiltration into the brain have demonstrated efficacy in multiple sclerosis (MS) treatment. However, their unpredictable adverse effects necessitate development of safer therapeutic alternatives. The choroid plexus (ChP) functions as a crucial barrier against invasion, and previous studies shown preventing across ChP reduces lesion MS animal models. Understanding regulation is therefore essential for identifying novel targets MS....
Abstract African swine fever virus (ASFV) is contagious and can cause highly lethal disease in pigs. ASFV DNA ligase (AsfvLIG) one of the most error-prone ligases identified to date; it catalyzes joining reaction during repair process plays important roles mutagenesis viral genome. Here, we report four AsfvLIG:DNA complex structures demonstrate that AsfvLIG has a unique N-terminal domain (NTD) critical substrate binding catalytic assembly. In combination with mutagenesis, vitro assays, our...
The human endogenous retroviruses type W family envelope (HERV-W env) gene is located on chromosome 7q21-22. Our previous studies show that HERV-W env elevated in schizophrenia and can increase calcium influx. Additionally, the 5-HTergic system particularly 5-hydroxytryptamine (5-HT) receptors play a prominent role pathogenesis treatment of schizophrenia. receptor 4 (5-HT4R) agonist block channels. However, underlying relationship between 5-HT4R etiology has not been revealed. Here, we used...
Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest that human endogenous retrovirus W family envelope (ERVWE1) is an influential risk factor for schizophrenia inversely correlates with 5-HT4 receptor To our knowledge, no data describes effect ERVWE1 on neuronal plasticity. N6-methyladenosine (m6A) regulates gene expression impacts Our research aims to systematically investigate effects through m6A modification...
African swine fever virus (ASFV) can cause highly lethal disease in pigs and is becoming a global threat. ASFV DNA Polymerase X (AsfvPolX) the most distinctive polymerase identified to date; it lacks two DNA-binding domains (the thumb domain 8-KD domain) conserved homologous proteins. AsfvPolX catalyzes gap-filling reaction during repair process of genome; error prone plays an important role strategic mutagenesis viral genome. The structural basis underlying natural substrate binding...
Abstract Background Increasingly studies highlight the crucial role of ancestral retrovirus envelope protein ERVWE1 in pathogenic mechanisms schizophrenia, a severe psychiatric disorder affecting approximately 1% global population. Recent also underscore significance circular RNAs (circRNAs), for neurogenesis and synaptogenesis, maintaining neuronal functions. However, precise relationship between circRNAs etiology schizophrenia remains elusive. Results This study observed elevated levels...
Abstract RNaseIII proteins are dsRNA-specific endonucleases involved in many important biological processes, such as small RNA processing and maturation eukaryotes. Various RNAs have been identified a protozoan parasite Entamoeba histolytica. Eh is the only endonuclease domain (RIIID)-containing protein E. histolytica . Here, we present three crystal structures that reveal several unique structural features of RNaseIII, especially interactions between two helixes (α1 α7) flanking RIIID core...
The choroid plexus (ChP) serves as a critical gateway for immune cell infiltration into the central nervous system (CNS) under both physiological and pathological conditions. Recent research has shown that regulating ChP activity may offer protection against CNS disorders. However, studying biological function of without affecting other brain regions is challenging due to its delicate structure. This study presents novel method gene knockdown in tissue using adeno-associated viruses (AAVs)...
The choroid plexus (ChP) serves as a critical gateway for immune cell infiltration into the central nervous system (CNS) under both physiological and pathological conditions. Recent research has shown that regulating ChP activity may offer protection against CNS disorders. However, studying biological function of without affecting other brain regions is challenging due to its delicate structure. This study presents novel method gene knockdown in tissue using adeno-associated viruses (AAVs)...