A5079167033- Hearing, Cochlea, Tinnitus, Genetics
- Music and Audio Processing
- Speech and Audio Processing
- Congenital heart defects research
- Microtubule and mitosis dynamics
- Hearing Loss and Rehabilitation
- RNA modifications and cancer
- Biochemical Analysis and Sensing Techniques
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- melanin and skin pigmentation
- Neuroscience of respiration and sleep
- Silk-based biomaterials and applications
- Photoreceptor and optogenetics research
- Hedgehog Signaling Pathway Studies
- Hydrogels: synthesis, properties, applications
- Child Abuse and Trauma
- Underwater Acoustics Research
- Skin and Cellular Biology Research
- Anesthesia and Neurotoxicity Research
- Marine animal studies overview
- RNA Research and Splicing
- Developmental Biology and Gene Regulation
- Cancer-related molecular mechanisms research
- Proteoglycans and glycosaminoglycans research
Creighton University
2025
Case Western Reserve University
2021-2024
University School
2021-2024
Université de Lorraine
2023
University of Liège
2012-2019
ABSTRACT Genetic loss-of-function studies on development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing differentiated state by a yet unknown mechanism. Here, we present results demonstrating major in maintaining nuclear organization heterochromatin architecture. Specifically, find substantial amount is associated with heterochromatic repeat sequences. We further identify sites interstitial decorated H3...
The transcription factor Lmx1a is widely expressed during early inner ear development, and mice lacking expression exhibit fusion of cochlear vestibular hair cells fail to form the ductus reuniens endolymphatic sac. dreher (Lmx1a dr/dr ), a recessive null mutation, results in non-functional expression, which expands from outer sulcus stria vascularis Reissner's membrane. In absence Lmx1a, we observe lack proteins specific vascularis, such as BSND KCNQ1 marginal CD44 intermediate cells....
Abstract Our sense of hearing is mediated by cochlear hair cells, which there are two types organized in one row inner cells and three rows outer cells. Each cochlea contains 5–15 thousand terminally differentiated their survival essential for as they do not regenerate after insult. It often desirable research to quantify the number within samples, both pathological conditions, response treatment. Machine learning can be used automate quantification process but requires a vast diverse...
Abstract Congenital hearing loss is the most common birth defect, estimated to affect 2‐3 in every 1000 births. Currently there no cure for loss. Treatment options are limited aids mild and moderate cases, cochlear implants severe profound Here we provide a literature overview of environmental genetic causes congenital loss, animal models methods used research, as well recent advances towards developing therapies treat deafness. © 2021 The Authors.
Intermediate cells of the stria vascularis are neural crest derived melanocytes. They essential for establishment endocochlear potential in inner ear, which allows mechanosensory hair to transduce sound into nerve impulses. Despite their importance normal hearing, how these develop and migrate position lateral wall cochlea has not been studied. We find that as early E10.5 some Schwann cell precursors VIIIth ganglion begin express melanocyte specific markers while melanoblasts otic vesicle....
The organ of Corti, the auditory mammalian inner ear, contains sensory hair cells and supporting that arise from a common progenitor. molecular bases allowing specification these progenitors remain elusive. In present study, by combining microarray analyses with conditional deletion Dicer in developing we identified miR-124 controls cell fate Corti. By targeting secreted frizzled-related protein 4 (Sfrp4) Sfrp5, two inhibitors Wnt pathway, showed β-catenin-dependent also PCP-related...
In the inner ear, neural crest gives rise to glia of VIII ganglion and two types melanocytic cells: The pigmented cells vestibular system intermediate stria vascularis. We analyzed transcriptome neonatal in an effort better understand development found that expression endothelin receptor B, which is essential for melanocyte development, persists long after birth. contrast, skin melanocytes rapidly downregulate EdnrB. Our findings suggest endothelins might have co-opted new functions ear...
The development of hearing in mammals requires the formation and maturation a highly organized specialized epithelium known as organ Corti. This contains two types cells, sensory which are true receptors auditory information, surrounding supporting composed developed cytoskeleton essential to architecture mature cells only mammalian reported contain unusual 15-protofilament microtubules. In this paper, we show that microtubules appear between second fourth day after birth pillar Corti mice....
Our sense of hearing is mediated by cochlear hair cells, localized within the sensory epithelium called organ Corti. There are two types cells in cochlea, which organized one row inner and three rows outer cells. Each cochlea contains a few thousands their survival essential for our perception sound because they terminally differentiated do not regenerate after insult. It often desirable research to quantify number samples, both pathological conditions, response treatment. However, sheer...