A5061315065- Cancer Mechanisms and Therapy
- Glutathione Transferases and Polymorphisms
- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- Tannin, Tannase and Anticancer Activities
- Prostate Cancer Treatment and Research
- Melanoma and MAPK Pathways
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
Imperial College London
2019-2021
Hammersmith Hospital
2019
The London College
2019
Androgen receptor (AR) signalling is a key prostate cancer (PC) driver, even in advanced 'castrate-resistant' disease (CRPC). To systematically identify microRNAs (miRs) modulating AR activity lethal disease, hormone-responsive and -resistant PC cells expressing luciferase-based reporter were transfected with miR inhibitor library; 78 inhibitors significantly altered activity. Upon validation, miR-346, miR-361-3p miR-197 markedly reduced transcriptional activity, mRNA protein levels,...
RSK4 promotes invasiveness and drug resistance in lung bladder cancer inhibition of this kinase shows therapeutic potential.
Abstract Lung cancer is the commonest cause of death worldwide with a five-year survival rate less than five percent for metastatic tumors. Non-small cell lung (NSCLC) accounts 80% cases which adenocarcinoma prevails. Patients almost invariably develop drug-resistant disease and this responsible our failure to provide curative therapy. Hence, better understanding mechanisms underlying these biological processes urgently required improve clinical outcome. The 90-kDa ribosomal S6 kinases...
Lung cancer is the commonest cause of death worldwide with a five-year survival rate less than five percent for metastatic tumors. Non-small cell lung (NSCLC) accounts 80% cases which adenocarcinoma prevails. Patients almost invariably develop drug-resistant disease and this responsible our failure to provide curative therapy. Hence, better understanding mechanisms underlying these biological processes urgently required improve clinical outcome.The 90-kDa ribosomal S6 kinases (RSKs) are...