A5039238977- Cerebrospinal fluid and hydrocephalus
- Migraine and Headache Studies
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Infections and Vaccines
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Advanced MRI Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoplatforms for cancer theranostics
- Photoreceptor and optogenetics research
- Medical Imaging Techniques and Applications
- Neural dynamics and brain function
- Multiple Sclerosis Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Central Venous Catheters and Hemodialysis
- Peripheral Neuropathies and Disorders
- Nonlinear Dynamics and Pattern Formation
- Hereditary Neurological Disorders
- Nanoparticle-Based Drug Delivery
- Rheumatoid Arthritis Research and Therapies
- Advanced Glycation End Products research
- Sleep and Wakefulness Research
Hacettepe University
2019-2025
Başkent University
2024
Massachusetts General Hospital
2021-2023
Harvard University
2021-2023
Center for Systems Biology
2021-2023
Abstract Cortical spreading depolarization (CSD), the neurophysiological event believed to underlie aura, may trigger migraine headaches through inflammatory signaling that originates in neurons and spreads meninges via astrocytes. Increasing evidence from studies on rodents patients supports this hypothesis. The transition pro-inflammatory anti-inflammatory mechanisms is crucial for resolving inflammation. However, resolution of inflammation context CSD remains poorly understood. This study...
The role of high mobility group box 1 (HMGB1) in inflammation is well characterized the immune system and response to tissue injury. More recently, HMGB1 was also shown initiate an "inflammatory signaling cascade" brain parenchyma after a mild brief disturbance, such as cortical spreading depolarization (CSD), leading headache. Despite substantial evidence implying for inflammatory prevalent neuropsychiatric disorders migraine depression, how released from healthy neurons initiated absence...
Abstract Interactions between the immune and central nervous systems strongly influence brain health. Although blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through border tissues, particularly dural lymphatic vessels allow cerebrospinal fluid outflow, facilitate intersystem communication. Here observe exits into skull bone marrow. Fluorescent tracers injected cisterna magna of mice travel hundreds sub-millimeter channels calvarial During meningitis,...
Abstract Although cortical spreading depolarizations (CSD) were originally assumed to be homogeneously and concentrically propagating waves, evidence obtained first in gyrencephalic brains later lissencephalic suggested a rather non-uniform propagation, shaped heterogeneously by factors like region differences, vascular anatomy, wave recurrences refractory periods. Understanding this heterogeneity is important better evaluate the experimental models on mechanistics of CSD make appropriate...
Purpose: We aimed to evaluate the clinical characteristics of Guillain Barré syndrome (GBS) patients retrospectively and identify prognostic factors associated with worse outcome at discharge end first month in GBS. Materials Methods: Patients who were followed up diagnosis GBS evaluated retrospectively. Demographic patients, cerebrospinal fluid examinations, treatment regimens, Medical Research Council (MRC) Hughes Motor Scale (HMS) scores recorded HMS ≥3 was accepted as poor prognosis...
Aim: A requirement for nanoparticle (NP) research is visualization of particles within cells and tissues. Limitations electron microscopy low yields NP fluorescent tagging warrant the identification alternative imaging techniques. Method: Confocal reflectance (CRM) in combination with fluorescence was assessed visualizing rhodamine B-conjugated silver fluorescein isothiocyanate-conjugated lipid core-stearylamine uptake vitro vivo. Results: CRM successfully identified cellular blood–brain...