A5046957566- Cystic Fibrosis Research Advances
- Advanced Chemical Sensor Technologies
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Antibiotic Resistance in Bacteria
- Neonatal Respiratory Health Research
- Antimicrobial Resistance in Staphylococcus
- Tracheal and airway disorders
- Antifungal resistance and susceptibility
- Gut microbiota and health
University of North Carolina at Chapel Hill
2022-2024
Lung Institute
2022-2024
The airway milieu of individuals with muco-obstructive diseases (MADs) is defined by the accumulation dehydrated mucus due to hyperabsorption surface liquid and defective mucociliary clearance. Pathological becomes progressively more viscous age disease severity concentration overproduction mucin host-derived extracellular DNA (eDNA). Respiratory MADs provides a niche for recurrent persistent colonization respiratory pathogens, including
Individuals with diabetes are prone to more frequent and severe infections, many of these infections being polymicrobial. Polymicrobial frequently observed in skin individuals cystic fibrosis, as well indwelling device infections. Two bacteria co-isolated from Staphylococcus aureus Pseudomonas aeruginosa. Several studies have examined the interactions between microorganisms. The majority use vitro model systems that cannot accurately replicate microenvironment diabetic We employed a novel...
People with cystic fibrosis (pwCF) suffer from chronic and recurring bacterial lung infections that begin very early in life contribute to progressive failure. CF is caused by mutations the transmembrane conductance regulator (CFTR) gene, which encodes an ion channel important for maintaining proper hydration of pulmonary surfaces. When CFTR function ablated or impaired, airways develop thickened, adherent mucus contributes a vicious cycle infection inflammation. Therapeutics pwCF, called...