A5088306861- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Reproductive Biology and Fertility
- Family Support in Illness
- Peroxisome Proliferator-Activated Receptors
- Acute Lymphoblastic Leukemia research
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- Vascular Malformations Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Polyomavirus and related diseases
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Cancer, Hypoxia, and Metabolism
- Renal Transplantation Outcomes and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Male Breast Health Studies
- Hematological disorders and diagnostics
- Neuroscience of respiration and sleep
Society for Endocrinology
2016-2020
Tokai University
2001-2017
Tokai University Hospital
2011
Washington University in St. Louis
2007
Vanderbilt University Medical Center
2003-2007
Vanderbilt University
2001
Cardiovascular Research Center
2001
An increasing number of long-term surviving bone marrow transplant (BMT) recipients have recovered from their primary disease but are at risk developing failure endocrine organs. We investigated 147 patients who underwent allogeneic BMT. Thyroid function was evaluated by serial measurement basal TSH and free T4 levels as well TRH provocative test. ultrasound examination performed for evaluation thyroid tumor after Five were found to overt dysfunction (hypothyroidism in four hyperthyroidism...
The peroxisome proliferator-activated receptor-alpha (PPARalpha) plays important roles in lipid metabolism, inflammation, and atherosclerosis. PPARalpha ligands have been shown to reduce cardiovascular events high-risk subjects. expression by arterial cells, including macrophages, may exert local antiatherogenic effects independent of plasma changes.To examine the contribution bone marrow-derived cells atherosclerosis, male female low-density lipoprotein receptor-deficient (LDLR(-/-)) mice...
We have previously reported that the lack of apolipoprotein (apo) E expression by macrophages promotes foam cell formation <i>in vivo</i>. Because transgenic mice overexpressing human apoA-I from liver (h-apoA-I TgN) are protected atherogenesis induced apoE deficiency, we hypothesized presence in vessel wall could reduce negative effect deficiency on lesion growth. To address this issue, used both retroviral transduction and approaches to produce<i>in vivo</i> systems where is expressed...
The concentration of apolipoprotein (apo) AI in the artery wall is thought to enhance cellular cholesterol efflux and protect against atherosclerosis. It has been shown that although macrophages do not make apoAI, they respond it by increased efflux. We hypothesized macrophage production apoAI would increase reduce atherogenesis. In this study, we produced mice expressing human under control macrophage-specific scavenger receptor-A promoter (mφ-AI). Human was detectable serum HDL fraction...
A pilot study was undertaken using a fludarabine-based conditioning regimen to improve haematopoietic cell transplantation (HCT) from alternative donors in 27 Fanconi anaemia (FA) patients. Patients were conditioned with 150-180 mg/m2 of fludarabine, 40 mg/kg cyclophosphamide, 5-10 antithymocyte globulin, and 300-450 cGy thoracoabdominal/total body irradiation. One patient who received unrelated cord blood failed engraft, another died sepsis. The 1-year overall survival 96.3% (95% CI,...
Radiation-induced cavernous hemangioma (RICH) is a late complication of cerebral radiation therapy. Long-term survivors hematopoietic stem cell transplantation (HSCT) who underwent therapy could be at increased risk for RICH. We investigated records 68 patients HSCT during childhood or adolescence and were assessed by magnetic resonance imaging (MRI), including T2*-weighted the brain, annually 5 years over range 6 to 29 after HSCT. developed scoring grading system RICH monitor process...
<h3>AIM</h3> To examine the long term effect of bone marrow transplantation (BMT) on ovarian function in girls. <h3>METHODS</h3> Eighteen girls who underwent BMT before menarche, had been disease free for more than six years, and were over 14 years age at time study investigated. The preparative regimen consisted irradiation chemotherapy. occurrence menarche changes basal serum follicle stimulating hormone (FSH) concentrations studied. <h3>RESULTS</h3> Twelve patients achieved a median 12.8...
Abstract The mechanisms that lead to mitochondrial damage under oxidative stress conditions were examined in primary and cultured cells as well the nematode Caenorhabditis elegans ( C. ) treated simultaneously with electron transport inhibitors oxygen gas. Oxygen loading enhanced of PC 12 by thenoyltrifluoroacetone (TTFA, a complex II inhibitor), but did not rotenone (a I antimycin III sodium azide IV inhibitor). In hepatocytes, enhancement was observed addition rotenone, TTFA or antimycin....
Abstract Background : Changes in thyroid function among young patients who received bone marrow transplantation (BMT) were evaluated. Methods The study included 91 (50 males) underwent BMT from 1985 to 1995 at the age of 0.6−21 years. Sixty had neoplastic disease such as leukemia or lymphoma, and remainder non‐neoplastic diseases. Preconditioning regimen for 12 Gy fractionated‐total body irradiation (TBI) with 3−8 remaining patients, addition chemotherapy. Evaluation was performed by serial...
The antiatherogenic effect of high-density lipoprotein (HDL) and its major protein component apolipoprotein A-I (apoA-I) has been largely attributed to their key roles in reverse cholesterol transport (RCT) cellular efflux. Substantial evidence shows that overexpression human apoA-I reduces atherosclerosis animal models. However, it is uncertain whether this protection due an increase plasma HDL level or a local the artery wall. To test hypothesis expression macrophages can promote RCT wall,...
An increasing number of pediatric cancer patients survive, and treatment-related infertility represents one the most important issues for these patients. While official guidelines in Japan recommend long-term follow-up childhood survivors (CCSs), their gonadal function fertility have not been clarified. To address this issue, we organized a working panel to compile evidence from who received treatments during or adolescence. In collaboration with members CCS Committee Japanese Society...
We recently used a bone marrow-based gene therapy approach to show that small amounts of retrovirus-derived human apolipoprotein E3 (apoE3) produced by macrophages are protective against early atherosclerosis in apoE-deficient mice.In the present study, we evaluated whether effect macrophage-derived apoE3 is related its ability bind cellular membranes. To this end, apoE2 and apoEcys142, dysfunctional variants with reduced binding LDL receptor or heparan sulfate proteoglycans, respectively....
Existing guidelines recommend long-term follow-up of childhood cancer survivors (CCS). However, in Japan, transitional care for CCS has not been established. To ascertain the current status and to cultivate a better understanding, questionnaire survey was conducted on CCS, adolescent young adult (AYA) survivors. Questionnaires were distributed 183 councilors (137 institutions) Japanese Society Pediatric Endocrinology. A total 131 responses, representative 174 councilors, obtained. The...
Growth hormone (GH) deficiency has been regarded as a principal determinant for growth failure following bone marrow transplantation (BMT). We herein analyzed final height and GH secretion in the patients who received BMT during childhood. The study on 30 (23 males; 19 with malignant disease) underwent before or at onset of puberty showed findings: (1) Final SD score (SDS) significantly decreased compared to pretreatment SDS. (2) Patients age 10 years greater reduction SDS those after years....
Fatty liver and male gonadal dysfunction are potential late effects of therapy in adult survivors treated with stem cell transplantation (SCT) childhood. Obesity metabolic syndrome also associated low serum testosterone levels the general population. However, relationship between degree fatty changes has not been fully studied. We reviewed clinical records 34 patients who received allogeneic SCT childhood or adolescence. The median age at was 10.0 years, follow-up after 15.9 years. All but...
Treatment plan for neonates with borderline hypothyroidism (persistent hyperthyrotropinemia normothyroxinemia) has not been established. In this study, changes in thyroid function after discontinuation of low-dose L-thyroxine (L-T4) supplement infants the condition were evaluated. Fourteen at neonatal screening had repeated (>8 mU/L) normothyroxinemia. TSH response was exaggerated TRH testing. The subjects treated L-T4 (3 to 9 μg/kg/day) 2.2 6 years, and euthyroid status maintained. After...
Turner syndrome is a chromosomal disease frequently associated with autoimmune disorders including diabetes mellitus, thyroid and inflammatory bowel (IBD). Although the etiology of IBD has not been fully elucidated, genetic analysis recently revealed several susceptibility genes. Recently, cases have reported. We report here 13-yr-old girl ulcerative colitis. The patient was undergoing growth hormone treatment presented abdominal discomfort bloody diarrhea. Her karyotype pattern 46,X,i(Xq)....
The number of long-term surviving stem cell transplant (SCT) recipients has increased steadily, and attention now extended to the late complications this procedure. objective study was investigate relationship among growth endocrine functions in adult survivors childhood SCT. inclusion criteria were survival at least 5 yr after SCT achievement height. Fifty-four patients (39 males) fulfilled these included study. Growth mainly evaluated by height standard deviation score (SDS) individual...