Fatma Yaylacı Karahalil

ORCID: 0000-0003-4767-8356
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Research Areas
  • Bee Products Chemical Analysis
  • Insect and Pesticide Research
  • Enzyme function and inhibition
  • Phytochemicals and Antioxidant Activities
  • Essential Oils and Antimicrobial Activity
  • Synthesis and biological activity
  • Free Radicals and Antioxidants
  • Cholinesterase and Neurodegenerative Diseases
  • Chemical Reactions and Mechanisms
  • Sexual Differentiation and Disorders
  • Molecular spectroscopy and chirality
  • Food Quality and Safety Studies
  • Thyroid Disorders and Treatments
  • Neuroendocrine Tumor Research Advances
  • Chemical Reaction Mechanisms
  • Meat and Animal Product Quality
  • Tea Polyphenols and Effects
  • Thyroid Cancer Diagnosis and Treatment
  • Healthcare and Venom Research
  • Computational Drug Discovery Methods
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Thyroid and Parathyroid Surgery

Karadeniz Technical University
2011-2024

Monoamine oxidase (MAO) inhibitors are generally used in the treatment of depressive disorders and some neurodegenerative illnesses, such as Parkinson's disease Alzheimer's disease. The aim this preliminary study was to investigate MAO [MAO (E.C.1.4.3.4)] inhibiting effect various apitherapeutic products, chestnut honey, pollen propolis. Extracts' inhibition measured using peroxidase-linked spectrophotometric assay enzyme isolated from rat liver microsomes, values expressed concentration...

10.3109/14756366.2013.843171 article EN Journal of Enzyme Inhibition and Medicinal Chemistry 2013-10-24

An α-carbonic anhydrase (CA, EC 4.2.1.1) was purified and characterized kinetically from erythrocytes of the sturgeon Acipenser gueldenstaedti, an endangered species. The enzyme (AgCA) showed kinetic parameters for CO2 hydration reaction comparable with those human hCA II, being a highly active enzyme, whereas its esterase activity 4-nitrophenyl acetate as substrate lower. Sulphonamide inhibitors (acetazolamide, sulphanilamide) strongly inhibited AgCA, metal ions (Ag+, Zn2+, Cu2+ Co2+) were...

10.3109/14756366.2011.554415 article EN Journal of Enzyme Inhibition and Medicinal Chemistry 2011-03-07

Background: Inflammatory hematological parameters like the neutrophil/lymphocyte (N/L) ratio have been investigated in many cancer types and significant relationships found with prognosis, for example. The aim of this present study was to investigate impact notably on N/L mean platelet volume (MPV) papillary thyroid cases. Materials Methods: A total 79 patients who underwent a thyroidectomy operation Findikli, Goiter Research Treatment Center during 2011-2015 period were enrolled study, 41...

10.7314/apjcp.2016.17.4.2321 article EN cc-by Asian Pacific Journal of Cancer Prevention 2016-06-01

Polyphenols are important secondary products of plants with the potential to inhibit carbonic anhydrases. The aim this study was investigate inhibition effects various phenolic standards, honey, propolis, and pollen species on human anhydrase I II. values (IC50) phenolics (gallic acid, protocatechuic quercetin, catechin, tannic chrysin) ranged from 0.009 0.32 μg/mL, acid emerging as best inhibitor. three different types heather, rhododendron, chestnut between 2.32 25.10 honeys exhibiting...

10.1080/14756366.2016.1221406 article EN Journal of Enzyme Inhibition and Medicinal Chemistry 2016-08-25

Abstract It is obvious that the oxidation process an undeniable fact and when it comes to aging, one of first solutions come mind natural products. When products, both plants bee products play important, almost combative role against oxidation. For this purpose, plant animal origin were considered together in our study: Linden, green tea, aronia, wild grapes, myrtle, blueberries basil, honey, pollen propolis. Total phenolic content values extracts ranged between 49.28 3859.06 mg gallic acid...

10.1002/cbdv.202301330 article EN Chemistry & Biodiversity 2024-01-15

Bu çalışmada (Camellia sinensis) çay çiçeğinin antioksidan aktivitesi, toplam flavonoid içeriği, fenolik içeriği ve yüksek performanslı sıvı kromatografi (HPLC) ile şeker antimikrobiyal aktivitesi incelendi istatistiksel olarak değerlendirildi. Yapılan bazı önemli sonuçlar bulundu; Toplam içerik (mg GAE - g), 28.641 ± 0.742; Quercetin 16.393 0.033; Antioksidan aktivite, DPPH (1,1-difenil-2-pikrilhidrazil radikal) Radikal Temizleme aktivitesi(Trolox mg mL), 0.0843 0.001. çalışmada, çiçeğinden...

10.35206/jan.641583 article TR Journal of Apitherapy and Nature 2019-11-09

Arı sütü binlerce çiçekten özümsenen nektar ve çiçek polenleri ile bal arılarının enzimlerini de içeren, akıcı jel halinde kremsi-beyaz renkteki etkili bir salgıdır. Besin değeri yüksek bu ürün amino asit, peptit, protein minerallerden oluşur. sütünün en önemli özelliği diğer arı ürünlerinde bulunmayan kısa zincirli hidroksi yağ asitlerince zengin oluşudur. Anti-bakteriyel, anti-tümoral, immün sistemi uyarıcı özelliğe sahip majör asidi trans-10-hidroksi-2-dekanoik asit (10-HDA)’dır. Yapılan...

10.29136/mediterranean.698926 article TR Mediterranean Agricultural Sciences 2020-12-16

Introduction: This study investigated the in vitro inhibition properties of newly synthesized coumarin derivates (C1-C5) against human carbonic anhdyrase I (hCA-I) and jack bean urease. Activities were expressed as IC50 (mg/mL), concentration reducing 50% enzymes. The values for hCA-I ranged 5.20 µM from 12.10 µM, with compound C3 exhibiting highest activity. urease 22.30 to 39.00 activity being observed C5. Conclusion: Comparing inhibitions standard inhibitors enzymes, while samples...

10.2174/1573408014666180903143132 article EN Current Enzyme Inhibition 2018-09-03
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