A5089253265- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Autophagy in Disease and Therapy
- Burn Injury Management and Outcomes
- Calcium signaling and nucleotide metabolism
- Lysosomal Storage Disorders Research
- Ion channel regulation and function
- Tendon Structure and Treatment
- Genetic and rare skin diseases.
- Sirtuins and Resveratrol in Medicine
- Nerve injury and regeneration
- Cardiac electrophysiology and arrhythmias
- Surface Modification and Superhydrophobicity
- Skin Protection and Aging
- Pediatric health and respiratory diseases
- Silk-based biomaterials and applications
- Acupuncture Treatment Research Studies
- Cell Adhesion Molecules Research
- Pressure Ulcer Prevention and Management
- Calpain Protease Function and Regulation
- Laser Applications in Dentistry and Medicine
- Neuroscience and Neuropharmacology Research
- Ion Transport and Channel Regulation
- Connexins and lens biology
- Leprosy Research and Treatment
Eulji University
2023
Hangang Sacred Heart Hospital
2014-2022
Hallym University
2014-2022
Health First
2012
Seoul National University Children's Hospital
2012
Catholic University of Korea
2005
Extracorporeal shock wave therapy (ESWT) considerably improves the appearance and symptoms of post-burn hypertrophic scars (HTS). However, mechanism underlying observed beneficial effects is not well understood. The objective this study was to elucidate changes in cellular molecular biology that induced by ESWT fibroblasts derived from scar tissue (HTSFs). We cultured primary dermal human HTS exposed these cells 1000 impulses 0.03, 0.1, 0.3 mJ/mm2. At 24 h 72 after treatment, real-time PCR...
Low-temperature plasma (LTP; 3 min/day), negative pressure wound therapy (NPWT; 4 h/day), and bone marrow mesenchymal stem cells (MSCs; 1×106 cells/day) were used as mono- combination in an acute excisional skin wound-healing ICR mouse model. These therapies have been beneficial treating wounds. We investigated the effectiveness of monotherapy with LTP, NPWT, MSC LTP + MSC, NPWT on wounds mice for seven consecutive days. Gene expression, protein epithelial thickness analyzed using real time...
Cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific RNA-binding that control translation via cytoplasmic polyadenylation. We previously reported CPEB1 or CPEB4 knockdown suppresses TAK1 and SMAD signaling in an vitro study.This study aimed to investigate whether suppression of expression inhibits scar formation a mice model acute dermal wound healing.CPEB1 levels were suppressed by siRNA treatment. Skin wounds created pressure-induced ulcers mice. Images the...
Abstract Introduction: Recent molecular studies of the original cases normokalemic periodic paralysis (normoKPP) have raised suspicions that these families actually had hyperkalemic (hyperKPP) due to mutations in skeletal muscle sodium channel gene SCN4A . However, there is still a debate about existence normoKPP. Methods: We screened 230 individuals with primary for , CACNA1S and KCNJ2 genes. All patients either hyperKPP or hypoKPP phenotype, none normoKPP phenotype. Results: In 4 from 2...
Familial hypokalemic periodic paralysis (HOKPP) is an autosomal dominant channelopathy characterized by episodic attacks of muscle weakness and hypokalemia. Mutations in the calcium channel gene, CACNA1S, or sodium SCN4A, have been found to be responsible for HOKPP; however, mechanism that causes hypokalemia remains determined. The aim this study was improve understanding investigating expression calcium-activated potassium (KCa) genes HOKPP patients.We measured intracellular concentration...
Batten disease is an inherited disorder characterized by early onset neurodegeneration due to the mutation of CLN3 gene. The function protein not clear, but association with oxidative stress has been proposed. Oxidative and DNA damage play critical roles in pathogenesis neurodegenerative diseases. Antioxidants are interest because their therapeutic potential for treating We tested whether N ‐acetylcysteine (NAC), a well‐known antioxidant, improves pathology cells from patients disease. At...
Resveratrol is a natural polyphenol that possesses various beneficial properties, such as anti‐inflammatory, anti‐oxidant, and neuroprotective effects. This study evaluated the potential therapeutic effects of resveratrol on primary fibroblasts derived from patient with Gaucher disease. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assays were carried out to determine whether affects cell survival. Changes in expression levels apoptosis‐inducing factor (AIF), Bax,...
The pore structure of INSUREGRAF® built up from parallel collagen layers connected by single fivers and sizes are very uniform. Therefore, this is more suitable with respect to cell penetration, distribution, acceleration skin regeneration.
Abstract Hypertrophic scars represent a common complication in burn patients. In addition to cosmetic defects, they may cause serious sensory abnormalities such as pain and itching, severe dysfunction depending on the site, emotional disorders anxiety depression. The present study aimed identify molecular mechanisms underlying use of extracorporeal shock wave therapy keratinocytes. Keratinocytes derived from hypertrophic scar tissue were cultured expression proliferation markers (keratin 5...
Gaucher disease (GD) is one of the most common lysosomal storage disorders and caused by an inherited deficiency in glucocerebrosidase. Resveratrol a phytoalexin that has many beneficial activities, including anti-oxidant, anti-apoptotic, neuroprotective effects. The aim this study was to determine if resveratrol therapeutic effect on primary fibroblast cells derived from patient with type II GD. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays were performed cell...
Hypertrophic scars, the most common complication of burn injuries, are characterized by excessive deposition fibroblast-derived extracellular matrix proteins. Calpain, a calcium-dependent protease, is involved in fibroblast proliferation and production observed certain fibrotic diseases. However, its role formation post-burn hypertrophic skin scars remains largely unknown. Here, calpain expression activity were assessed fibroblasts obtained directly from patients with third-degree burns, who...
고셔병은 세포내의 글루코세레브로시데이즈의 결핍으로 인하여 리소좀 내의 글루코세레브로사이드가 분해되지 못하고 축적되는 질환으로 알려져 있으며, 유형의 종류에 따라 신경퇴행성 나타나는 것으로 보고되어 있으나 아직까지 정확한 기전이 밝혀져 있지 않다. 본 논문에서는 항산화 효과 및 신경보호 효과가 있는 알려진 레스베라트롤을 고셔병 환자의 fibroblast 세포에 투여하여 세포 생존율 변화 여부 세포주기 조절에 관하여 분자 생물학적 기전을 알아보고자 하였다. 세포의 p21의 mRNA 발현 수준과 단백질 양상을 확인한 결과 상의 정량적 차이는 관찰되지 않았으나 발현수준은 레스베라트롤의 농도가 높아짐에 증가 되는 것을 확인하였다. 또한 세포사멸의 표지 인자 단백질로 PARP의 변화양상을 감소하는 확인 할 수 있었다. 이를 통해 폴리페놀계 천연물인 레스베라트롤이 고셔병에서 손상을 치유하며, 궁극적으로 세포사멸을 억제하는 효과를 가져올 생각할 질환에서 병증을 완화 시킬 있을 사료된다....