A5003272718- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Spine and Intervertebral Disc Pathology
- Anesthesia and Pain Management
- Myofascial pain diagnosis and treatment
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Placebo Effect
- Pain Management and Opioid Use
- Shoulder Injury and Treatment
- Spinal Fractures and Fixation Techniques
- Cancer Treatment and Pharmacology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- Nerve Injury and Rehabilitation
- Pelvic and Acetabular Injuries
- Botulinum Toxin and Related Neurological Disorders
- Opioid Use Disorder Treatment
- Scoliosis diagnosis and treatment
- Spinal Hematomas and Complications
- Pregnancy-related medical research
- Medical Imaging and Analysis
- Neuroendocrine Tumor Research Advances
Brigham and Women's Hospital
2017-2025
Robert Wood Johnson University Hospital
2024-2025
Eli Lilly (United States)
2023-2025
Harvard University
2011-2024
OSRAM (United States)
2023-2024
Hudson Institute
2022-2024
John Wiley & Sons (United States)
2019-2024
Chestnut Hill College
2020-2024
Rutgers, The State University of New Jersey
2024
Lemuel Shattuck Hospital
2024
Epidural glucocorticoid injections are widely used to treat symptoms of lumbar spinal stenosis, a common cause pain and disability in older adults. However, rigorous data lacking regarding the effectiveness safety these injections.In double-blind, multisite trial, we randomly assigned 400 patients who had central stenosis moderate-to-severe leg receive epidural glucocorticoids plus lidocaine or alone. The received one two before primary outcome evaluation, performed 6 weeks after...
BackgroundAdults with refractory, mechanical chronic low back pain associated impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized restorative neurostimulation, a rehabilitative activates muscles to overcome underlying dysfunction, is safe and provides relevant durable benefit patients this specific etiology.Materials MethodsIn prospective five-year longitudinal follow-up ReActiv8-B pivotal...
Letters17 April 2012Defining Patient ComplexityJoseph M. Cerimele, MD and Lauren A. Peccoralo, MD, MPHJoseph MDFrom Mount Sinai School of Medicine, New York, NY 10029.Search for more papers by this author MPHFrom authorAuthor, Article, Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-8-201204170-00002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Grant colleagues (1) highlighted the...
<h3>Objectives</h3> The purpose of the international multicenter prospective single arm clinical trial was to evaluate restorative neurostimulation eliciting episodic contraction lumbar multifidus for treatment chronic mechanical low back pain (CMLBP) in patients who have failed conventional therapy and are not candidates surgery or spinal cord stimulation (SCS). <h3>Materials Methods</h3> Fifty-three subjects were implanted with a neurostimulator (ReActiv8, Mainstay Medical Limited, Dublin,...
Abstract Chronic low back pain can be caused by impaired control and degeneration of the multifidus muscles consequent functional instability lumbar spine. Available treatment options have limited effectiveness prognosis is unfavorable. We conducted an international randomized, double-blind, sham-controlled trial at 26 multidisciplinary centers to determine safety efficacy implantable, restorative neurostimulator designed restore neuromuscular facilitate relief symptoms (clinicaltrials.gov...
Impaired neuromuscular control and degeneration of the multifidus muscle have been linked to development refractory chronic low back pain (CLBP). An implantable restorative-neurostimulator system can override underlying inhibition by eliciting episodic, isolated contractions. The ReActiv8-B randomized, active-sham-controlled trial provided effectiveness safety evidence for this system, all participants received therapeutic stimulation from four months onward. This study aimed evaluate...
Restorative neurostimulation is a rehabilitative treatment for patients with refractory chronic low back pain (CLBP) associated dysfunction of the lumbar multifidus muscle resulting in impaired neuromuscular control. The ReActiv8-B randomized, sham-controlled trial provided evidence effectiveness and safety an implanted, restorative neurostimulator. two-year analysis previously published this journal demonstrated accrual clinical benefits long-term durability. Evaluation three-year...
Spinal cord stimulation (SCS) is effective for relieving chronic intractable pain conditions. The Dorsal spInal STImulatioN vs mediCal management the Treatment of low back study evaluates effectiveness SCS compared with conventional medical (CMM) in treatment patients who had not undergone and were candidates lumbar spine surgery.
Spinal cord stimulation (SCS) has been challenged by the lack of neurophysiologic data to guide therapy optimization. Current SCS programming trial-and-error results in suboptimal and variable therapeutic effects. A novel system with a physiologic closed-loop feedback mechanism using evoked-compound action potentials enables optimization neural dose consistently accurately activating spinal fibers. We aimed identify metrics their ranges that resulted clinically meaningful treatment responses.
Patients in remote areas lack access to specialist care and pain management services. In order provide patients from our center, we created a telemedicine clinic (telepain) at Massachusetts General Hospital (MGH) Boston, MA extend services the Island of Martha's Vineyard.Over 13 months, 238 telepain video evaluations were conducted. A physician visited island 1-2 days per month performed 121 interventions. Given novelty clinics, surveyed gauge satisfaction identify perceived weaknesses...
The purpose of the ongoing follow-up ReActiv8-A clinical trial is to document longitudinal benefits episodic stimulation dorsal ramus medial branch and consequent contraction lumbar multifidus in patients with refractory mechanical chronic low back pain (CLBP). We report four-year outcomes this trial.ReActiv8-A a prospective, single-arm performed at nine sites United Kingdom, Belgium, Australia. Eligible had disabling CLBP (low Numeric Rating Scale [NRS] ≥6; Oswestry Disability Index [ODI]...