A5100380814- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Esophageal Cancer Research and Treatment
- Galectins and Cancer Biology
- Intergenerational Family Dynamics and Caregiving
- IL-33, ST2, and ILC Pathways
- Genital Health and Disease
- Potassium and Related Disorders
- Ocular Oncology and Treatments
- Lung Cancer Treatments and Mutations
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Intestinal and Peritoneal Adhesions
- Sinusitis and nasal conditions
- Cerebral Venous Sinus Thrombosis
- Sexual function and dysfunction studies
- Gastrointestinal Tumor Research and Treatment
- RNA Research and Splicing
- Diphtheria, Corynebacterium, and Tetanus
- Peptidase Inhibition and Analysis
- Nutrition, Genetics, and Disease
- Microbial Metabolites in Food Biotechnology
Wenzhou Medical University
2024-2025
Xi'an Medical University
2020-2024
Institute of Immunology
2024
Shanghai Jiao Tong University
2024
Xi'an Jiaotong University
2024
Kaiser Permanente
2016-2023
Jiangnan University
2023
Wuxi Fourth People's Hospital
2023
Guangzhou University of Chinese Medicine
2022
Kaiser Permanente Santa Clara Medical Center
2021
Gastric intestinal metaplasia and dysplasia are precursor lesions for adenocarcinoma. The risks of progression to malignancy from these not well characterized, particularly in the US populations.We identified 4,331 Kaiser Permanente Northern California members who were diagnosed with gastric or between 1997 2006 followed them through December 2013. incident rates adenocarcinoma, relative comparison general population, predictors investigated.Among 4,146 individuals 141 low-grade 24,440...
To evaluate the relationship between gastric cancer (GC) and precancerous lesions bile reflux.Medical records of 30 465 participants who underwent gastroscopy January December 2018 in our center were reviewed. Their age, sex, time endoscopy, endoscopic/histologic diagnosis grade reflux recorded. The further divided into chronic gastritis group (n = 27 807), a lesion 1943) GC 715). χ2 tests hierarchical analyses performed.Patients aged 18-27 years had higher rate than those 28-37 68-75 (P <...
Objective To identify whether bile reflux on endoscopy and other related variables are risk factors for precancerous gastric lesions cancer (GC). Methods A multicenter, cross‐sectional observational study was conducted in five centers China from June to October 2019, 1162 patients were recruited divided into the chronic gastritis (CG), lesion (low‐grade intraepithelial neoplasia intestinal metaplasia), GC groups (including high‐grade neoplasia). All participants underwent detailed...
Abstract Helicobacter pylori is one of the main predisposing factors for gastric cancer, causing chronic inflammation and proper glands atrophy in mucosa. Although H. ‐induced a key inducer precancerous lesions mucosa, it remains unclear which precise immune cell subsets are responsible progression gastritis. Here, we observed an abundance CD4 + IL‐17A FOXP3 T cells exhibiting Th17‐like phenotype within microenvironment Mechanistically, upregulated expression IL‐6 Dendritic macrophages, by...
Helicobacter pylori (H pylori) infection plays a critical role in gastritis-associated diseases, gastroduodenal ulcers, and even gastric cancer. Studies have shown that probiotics may exhibit antagonistic activity against H pylori.This study aimed to assess the efficacy safety of monotherapy with Clostridium butyricum (C butyricum) Bacillus coagulans (B coagulans) for treatment. Our research was an open-label, single-arm pilot eradication. Subjects diagnosed as outpatients at Xijing Hospital...
Mechanisms whereby acid reflux may accelerate the progression from Barrett9s esophagus (BE) to esophageal adenocarcinoma (EA) are not fully understood. We have previously shown that NADPH oxidase NOX5-S generates reactive oxygen species (ROS) when metaplastic cells exposed acid. Besides cells, other H<sub>2</sub>O<sub>2</sub>-producing (e.g., inflammatory cells) present in BE mucosa produce additional ROS, which also affect contributing tumorigenesis. In this study, we investigate whether...
Summary Background Studies have showed that 10‐day sequential treatment regimen achieved higher Helicobacter pylori eradication rate than standard triple therapies. Aim To compare a therapy and in Chinese children with H . infection. Methods A prospective, multicentre, open‐label, randomised controlled trial was conducted four tertiary medical centres China. Children gastritis were randomly assigned to consisting of omeprazole amoxicillin for 5 days followed by omeprazole, clarithromycin...
A large number of patients with iron deficiency anemia have no known cause their despite a full evaluation. Optimal management and follow-up for this issue is unclear. Results previous studies implicated Helicobacter pylori infection as potential anemia.
Abstract Context CD34+ orbital fibroblasts (OFs) play a pathogenic role in thyroid eye disease (TED). Several micro (mi)RNAs have been shown to promote TED progression. Objective This study aims explore the regulatory effects of miRNAs on OFs and find potential therapeutic targets. Methods In this case-control study, connective tissues (OCTs) were obtained from 25 patients 24 healthy donors. MiRNA-seq was performed examine differential expression OCTs, miR-182-5p selected for subsequent...
Chronic atrophic gastritis (CAG) is a very common and one of the major precursor lesions gastric cancer, most cancers worldwide. The molecular mechanism underlying CAG unclear, but its elucidation essential for prevention early detection cancer appropriate intervention. A combination two-dimensional gel electrophoresis mass spectrometry was used in present study to analyze differentially expressed proteins. Samples from 21 patients (9 females 12 males; mean age: 61.8 years) were used. We...
To use health economics methodology to assess the screening program on gastric cancer in Zhuanghe, China, so as provide basis for decision expanding of early detection and treatment.The expense an treatment patients found by screening, also costs traditional a hospital Zhuanghe were assessed. Three major techniques medical economics, namely cost-effective analysis (CEA), cost-benefit (CBA) cost-utility (CUA), used program.RESULTS from CEA showed that investing every 25, 235 Yuan area, one...
Gastrin is a hormone that physiologically regulates gastric acid secretion and contributes to the maintenance of epithelial architecture by regulating expression genes such as regenerating gene 1 (Reg1). Reg1 involved in carcinogenesis an antiapoptotic factor. The current study explores molecular mechanism gastrin-regulated human cancer cells. In total, five intron fragments were cloned polymerase chain reaction inserted into luciferase reporter vector pGL3 construct intron-luciferase...
Purpose: We conducted a multicenter cross-sectional study in central and western China to explore the association between inflammatory diet stomach cancer odds. Patients Methods: Participants from five hospitals regions were collected. All participants completed questionnaire we provided before gastroscopy examination, which includes inquiries about risk factors for food frequency. underwent gastroscopy, mucosal biopsy was confirmed pathologically. Pathological findings classified as chronic...
Epilepsy is a chronic neurological disorder that characterized by episodes of seizure. Sexual dysfunction has been reported in patients with seizure, which mostly manifests as erectile and premature ejaculation men. In this study, we report the case 65-year-old Chinese man frequent spermatorrhea. Electroencephalography suggested local epilepsy left temporal lobe. After treatment anti-epilepsy drugs, symptoms disappeared did not recur. To best our knowledge, first epilepsy-induced The...