A5102740805- Molecular Sensors and Ion Detection
- Plant Virus Research Studies
- Influenza Virus Research Studies
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- HIV Research and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- interferon and immune responses
- Synthesis and Characterization of Heterocyclic Compounds
- Insect Resistance and Genetics
- Insect-Plant Interactions and Control
- DNA and Nucleic Acid Chemistry
- HIV/AIDS drug development and treatment
- Animal Virus Infections Studies
- Analytical Chemistry and Sensors
- Viral Infections and Vectors
- Phenothiazines and Benzothiazines Synthesis and Activities
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Supramolecular Chemistry and Complexes
- Electrochemical Analysis and Applications
- Antimicrobial Peptides and Activities
- Click Chemistry and Applications
- Insect and Pesticide Research
- Melamine detection and toxicity
Shandong University
2022-2023
Suzhou Research Institute
2023
Shenyang Pharmaceutical University
2019-2023
Jiangsu Food and Pharmaceutical Science College
2022
Xi'an Jiaotong University
2020
Yanbian University
2017-2018
Wuhan University
2004-2006
The complete nucleotide sequence of a new insect picorna-like virus, Ectropis obliqua virus (EoPV), which causes fatal infection larvae, has been determined. genomic RNA EoPV is 9394 nt in length and contains single, large open reading frame (nt 391–9351) encoding polyprotein 2987 aa. Sequence comparisons with other viral polyproteins revealed that the consensus sequences for picornavirus helicase, protease RNA-dependent polymerase proteins are found on genome order 5′→3′ direction. All...
A new series of novel 7-hydroxy-4-phenylchromen-2-one (1a)-linked 1,2,4-triazoles were synthesised using a click chemistry approach. All derivatives subjected to 3-(4,5-dimethylthiazol-yl)-diphenyl tetrazolium bromide (MTT) cytotoxicity screening against panel six different human cancer cell lines (AGS, MGC-803, HCT-116, A-549, HepG2, and HeLa) assess their cytotoxic potential. Among the tested molecules, some analogues showed better activity than that shown by (1a). Of 1,2,4-triazoles,the...
To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of novel boron-containing N-substituted oseltamivir derivatives were designed and synthesized target the 150-cavity (NA). In NA inhibitory assays, it was found that most new compounds exhibited moderate potency against wild-type NAs. Among them, compound 2c bearing 4-(3-boronic acid benzyloxy)benzyl group displayed weaker or slightly improved activities group-1 NAs (H1N1, H5N1, H5N8 H5N1-H274Y) compared...
The nucleotide sequence of a novel icosahedral DNA virus infecting Dendrolimus punctatus has been determined. genome is 5039 nt long and includes inverted terminal repeats 200 containing 131 J-shaped hairpins. 'plus' strand the contains three large open reading frames (ORFs), left mid-ORFs (within ORF) in left-half encoding non-structural proteins right ORF right-half viral capsid proteins. NS1 protein conserved replication initiation DNA-dependent ATPase/helicase domains. VP1 PGY...
Ectropis obliqua picorna-like virus (EoPV) is a newly described insect that classified as putative member of the genus Iflavirus . The possesses large, positive-sense RNA genome encoding single polyprotein shares physicochemical properties with those members family Picornaviridae 5′ untranslated region (5′ UTR) plays an important role in picornavirus translation initiation, it contains internal ribosome entry site (IRES) mediates cap-independent translation. To investigate EoPV, extensive...
To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives substituted benzene moieties at the C17 position were designed, synthesised, evaluated for their antiproliferative properties. Most exhibited effects against AGS, MGC803, Bel7402, HCT116, A549, HeLa cells. Compound 2p (IC50 = 1.05 µM) most potent activity HCT116 cells; it was more than 6.84 5-fluorouracil (5-FU) 24.80 µM). The IC50 value in L02 cells 6.5-fold that Overall, better selective...
We report the design, synthesis, and mechanistic study of a novel series 2-piperazineone peptidomimetics as HIV capsid modulators by mimicking structure host factors binding to CA.
In this study, Dendrolimus punctatus tetravirus (DpTV) has been identified as a new member of the genus Omegatetravirus family Tetraviridae that may be related serologically to Nudaurelia capensis omega virus (NomegaV). DpTV particles are isometric, with diameter about 40 nm and buoyant density 1.281 g cm(-3) in CsCl. The two capsid proteins (of 62 500 6800 Da) single-stranded RNA molecules (RNA1 RNA2), which 5492 2490 nt long, respectively. RNA1 large open reading frame (ORF) encoding...
Hydrazone bond formation under physiological conditions remains challenging. In this study, bis(salicylaldehyde hydrazone) was synthesized using supramolecular catalysis and its AT-DNA ratiometric sensing properties were identified.
Ketocalix[3]carbazole, a facilely synthesized rigid “basket” capable of sensing baicalin.
A series of novel 3-[2-(4H-1,2,4-triazol-4-yl)ethyl]-1-alkyl-1H-indole derivatives (4a-s) were synthesized and evaluated for their anticonvulsant activity neurotoxicity by using maximal electroshock (MES) rotarod (TOX) tests. Among the compounds studied, compound 3-[2-(4H-1,2,4-triazol-4-yl)ethyl]-1-nonyl-1H-indole (4p) was found intraperitoneal (i.p.) administration in mice to be most potent with a median effective dose (ED50) value 10.2 mg/kg, possessed better higher safety than...
A series of novel oleanolic acid (OA)-linked disulfide, thioether, or selenium ether derivatives was synthesized, and their antiproliferative activity evaluated against human liver cancer (BEL-7402 HepG-2), colon (HCT116), normal (L02) cell lines using methyl thiazolyl tetrazolium assay (MTT). Preliminary bioassay results revealed that OA modified at the C3-OH position, i. e., compound a4 containing sulfide ether, exhibited best BEL-7402 cells, with an IC50 value 5.70±0.82 μM. Further flow...