A5084872625- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Inflammasome and immune disorders
- Bacterial Identification and Susceptibility Testing
- Cell Image Analysis Techniques
- Streptococcal Infections and Treatments
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Biochemical and Structural Characterization
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Microbial Metabolism and Applications
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Signaling Pathways in Disease
- Single-cell and spatial transcriptomics
The University of Queensland
2024-2025
Peter Doherty Institute
2021-2023
The University of Melbourne
2021-2023
National University of Singapore
2020
A mechanistic connection between aging and development is largely unexplored. Through profiling age-related chromatin transcriptional changes across 22 murine cell types, analyzed alongside previous mouse human organismal maturation datasets, we uncovered a transcription factor binding site (TFBS) signature common to both processes. Early-life candidate cis-regulatory elements (cCREs), progressively losing accessibility during aging, are enriched for cell-type identity TFBSs. Conversely,...
Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. can persist and replicate within host cells, evading immune responses, causing cell death. Classical methods for assessing cytotoxicity limited by testing culture supernatants endpoint measurements that do not capture the phenotypic diversity of intracellular bacteria. Using a well-established epithelial line model, we have developed platform called InToxSa (intracellular...
Abstract Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. can persist and replicate within host cells, evading immune responses causing cell death. Classical methods for assessing cytotoxicity limited by testing culture supernatants endpoint measurements that do not capture the phenotypic diversity of intracellular bacteria. Using a well-established epithelial line model, we have developed platform called InToxSa ( In...