A5020768269- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Microbial bioremediation and biosurfactants
- Water Quality Monitoring and Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer-related molecular mechanisms research
- Environmental Toxicology and Ecotoxicology
- RNA modifications and cancer
- Analytical chemistry methods development
- Environmental Chemistry and Analysis
- Environmental remediation with nanomaterials
- Computational Drug Discovery Methods
- Heavy metals in environment
- Water Quality and Pollution Assessment
- Surfactants and Colloidal Systems
- RNA Research and Splicing
- Air Quality and Health Impacts
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Water Treatment and Disinfection
- vaccines and immunoinformatics approaches
- Pesticide and Herbicide Environmental Studies
- Per- and polyfluoroalkyl substances research
- Mineral Processing and Grinding
- Cancer Immunotherapy and Biomarkers
China University of Mining and Technology
2022-2025
Jiangsu University of Science and Technology
2024-2025
University of Houston - Clear Lake
2015-2024
Sichuan Agricultural University
2018-2024
West Anhui University
2021-2024
Northeast Forestry University
2022-2024
Harbin Medical University
2014-2024
Wuhan University
2023-2024
Renmin Hospital of Wuhan University
2023-2024
Shanxi Province Hospital of Traditional Chinese Medicine
2015-2024
Bisphenol S (4-hydroxyphenyl sulfone, BPS) is increasingly used as a bisphenol A (BPA) alternative. The global usage of BPS and its analogues (BPSs) resulted in the frequent detection their residues multiple environmental media. We investigated potential endocrine-disrupting effects toward thyroid hormone receptor (TR) β. molecular interaction BPSs TRβ ligand binding domain (LBD) was probed by fluorescence spectroscopy dynamics (MD) simulations. caused static quenching LBD. 100 ns MD...
As the substitute of polybrominated diphenyl ethers (PBDEs), further assessments about potential ecological safety and health risks phosphorus-containing flame retardants (PFRs) are required because worldwide demand for PFRs has been increasing every year. In this study, we examined agonistic/antagonistic activity a group by three in vitro models (luciferase reporter gene assay, yeast two-hybrid E-screen assay). Molecule docking was used to explain interactions between ERα PFRs. Data from...
In the past two decades, neonicotinoid insecticides have been widely used in agricultural activities China. Many previous studies investigated pollution aquatic ecosystems, but status of water safety uses China is very scarce. The present study aims to reveal spatial and temporal distribution neonicotinoids rivers, then evaluate ecological risks animals. Water samples were collected from all sixteen rivers along east coast during dry wet seasons 2016, nine individual commercialized...
Parabens have been widely used in packaged foods, pharmaceuticals, and personal-care products. Considering their potential hydrolysis, we herein investigated structural features leading to the disruption of human androgen receptor (AR) whether hydrolysis could alleviate such effects using recombinant yeast two-hybrid assay. with an aryloxy side chain as benzyl paraben phenyl strongest antiandrogenic activity. The activity parabens alkyloxyl chains decreases length increases from 1 4, no...
Inorganic arsenic (iAs) in its dominant dissolved phase the environment is known to pose major threats ecological and human health. While biological effects many arsenic-bearing freshwaters have been extensively studied, behavior bioaccumulation of iAS presence extracellular polymeric substances (EPS) still remains be a critical knowledge gap. In this study, uptakes kinetic characteristics iAs were studied using Chlorella pyrenoidosa (a typical freshwater green algae) by addressing different...
Pentabromoethylbenzene (PBEB), as one of the novel brominated flame retardants (NFBRs), has caused increasing public concern for health risks. Till now, information regarding potential effects PBEB on thyroid function remains unclear. Herein, we investigated disruption in vitro and silico evaluated dysfunction induced by using Sprague–Dawley rats. showed receptor (TR) β antagonistic activity with IC50 9.82 × 10–7 M dual-luciferase reporter gene assay relative reorientation helix 11 (H11) H12...
Persistent, mobile, and toxic (PMT) substances very persistent mobile (vPvM) can transport over long distances from various sources, increasing the public health risk. A rapid high-throughput screening of PMT/vPvM is thus warranted to risk prevention mitigation measures. Herein, we construct a machine learning-based system integrated with five models for classification substances. The are constructed 44 971 by conventional learning, deep ensemble learning algorithms, among which, LightGBM...
Bisphenol A analogues (BPAs) belong to a wide variety of large volume chemicals with diverse applications yet emerging environmental concerns. Limited experimental data have demonstrated that BPAs different halogenation patterns distinctly affect the agonistic activities toward proliferator-activated receptor (PPAR)γ and estrogen receptors (ER)α. Understanding modes action is essential, however, underlying molecular mechanism still poorly understood. Here we probed recognition process...
The potential of porous diatom silica shells as a naturally abundant low-cost sorbent for the removal arsenic in aqueous solutions was investigated batch study. objective this work to chemically modify Melosira sp. with bifunctional (thiol and amino) groups effectively remove its toxic As(III) form (arsenite) predominant aquatic environment. Sorption experiments novel were conducted under varying conditions pH, time, dosage, concentration. A maximum adsorption capacity 10.99 mg g-1 achieved...
The detection of cherry tomatoes in greenhouse scene is great significance for robotic harvesting. This paper states a method based on deep learning to reduce the influence illumination, growth difference, and occlusion. In view such operating environment accuracy learning, Single Shot multi-box Detector (SSD) was selected because its excellent anti-interference ability self-taught from datasets. first step build datasets containing various conditions greenhouse. According characteristics...
Iron-based nanomaterials hold promise for in situ remediation of persistent halogenated contaminants such as dioxin-like polychlorinated biphenyls, however, their complex interactions and joint toxicity toward beneficial soil biological functions remain unknown. This study examined the effects nano-zero valent iron (nZVI) on physiological morphological changes, bioaccumulation co-existed 3,3′,4,4′-tetrachloro-biphenyls (PCB77), nZVI PCB77 earthworms Eisenia fetida. An orthogonally designed...
Nitrated and oxygenated polycyclic aromatic hydrocarbons (NPAHs OPAHs) from the direct atmospheric emission or degradation of parent PAHs are increasingly recognized because their potential health risks. Herein, we investigated effects four NPAHs/OPAHs (1-NNAP, 9-NANT, 9,10-AQ, 9-FLU) (NAP, ANT, FLU) on endothelium function with regard to endothelial nitric oxide synthase (eNOS) endothelium-derived (NO) production in human umbilical vein cells. The eNOS enzymatic activity NO were promoted by...
3,3′,5,5′-Tetrabromobiphenyl (BB-80) was once used as additive flame retardants. Whether its early exposure and discontinued alter thyroid function remains unknown. We investigate adverse effects after early-life to BB-80 hydroxylated (OH-BB-80) on hormone (TH) levels, tissue, transcriptome profiles in zebrafish larvae. at 10 μg/L induces pathological changes of with reduced follicles larvae (P < 0.05), whereas OH-BB-80 significantly increases T4 T3 contents (1.8 2.5 times the control, P...
This study aims to explore the core symptoms of Non-Suicidal Self-Injury (NSSI) in adolescents with depressive disorders and relationship between childhood maltreatment (CM) NSSI by using network analysis. A total 689 participated survey. The Chinese version Adolescent Assessment Questionnaire (ANSAQ) Short Form Childhood Trauma (CTQ-SF) were employed measure CM, respectively. Using analysis, CM-NSSI constructed identify most central bridge within networks. Within network, "Intentional...
Increased epidemiological evidence indicates the association of bisphenol exposure with human vascular disorders, while underlying mechanism has not been clarified. Here, we sought to unveil potential angiogenic effect and bisphenols different structural features using endothelial cells treated an environmentally relevant concentration (range: 1 nM 10 μM) a C57BL/6 mouse model fed doses 0.002, 0.02, 2, 20 mg/kg BW/day for 5 weeks. Bisphenol A (BPA) S (BPS) at level significantly increased...
The greatest concern over DDT exposure in China arose since the early 1990s for rising breast cancer incidence, and cause still remains to be elucidated. An extensive survey of background agricultural soils, covered entire region China, was conducted. at concentrations greater than 100 ng/g (the China's Farmland Environmental Quality Evaluation Standards Edible Agricultural Products) found impact 42.3 million Chinese population. Considering geographical differences with diverse contributions...