A5008386663- Berberine and alkaloids research
- Chemotherapy-induced organ toxicity mitigation
- Drug Transport and Resistance Mechanisms
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Andrographolide Research and Applications
- Pharmacological Effects and Toxicity Studies
- Phytochemistry and Biological Activities
- Estrogen and related hormone effects
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Asymmetric Hydrogenation and Catalysis
- Tryptophan and brain disorders
- Hormonal Regulation and Hypertension
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Sesame and Sesamin Research
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- ATP Synthase and ATPases Research
- Nerve injury and regeneration
- Essential Oils and Antimicrobial Activity
- Cancer, Stress, Anesthesia, and Immune Response
Gannan Medical University
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
China Academy of Chinese Medical Sciences
2022
Background: Acute kidney injury (AKI) is a syndrome, posing substantial healthcare burden. The pathological basis of AKI associated with inflammation and oxidative stress which cause additional damage to mitochondria. Artesunate (ATS) derivative artemisinin isolated from Artemisia annua L . that an effective treatment for malaria favored the prevention diseases. However, there are still challenges related its efficacy, including poor water solubility, limited oral bioavailability short...
As shown in our previous study, sinomenine hydrochloride (SH), the major bioactive alkaloid isolated from Sinomenium acutum Rehd. et Wils. (Fam. Menispermaceae), initiates autophagy-mediated death of human glioblastoma cells by generating reactive oxygen species and activating autophagy-lysosome pathway. However, its effects on migration invasion have not yet been elucidated. Therefore, U87 SF767 were treated with SH (0.125 0.25 mM) for 24 h, cell assessed using scratch wound healing,...
Glioblastoma is the most common malignant primary brain tumor, and it one of causes cancer fatality in both adult pediatric populations. Patients with glioblastoma require chemotherapy after surgical resection radiotherapy. Therefore, constitutes a viable approach for eradication cells. In this study, anti-tumor activity sinomenine hydrochloride (SH) was evaluated U87 SF767 cells vitro vivo. The results showed that SH potently inhibited cell viability did not cause caspase-dependent death,...
Hepatocellular carcinoma (HCC) is one of the most frequent cancers. Sinomenine (SIN) a compound derived from Sinomenium acutum. Our previous investigations have found that SIN inhibited protein kinase B (AKT) signaling to induce autophagic death tumor cells. However, whether inhibition this pathway by could impact proliferation HCC cells unknown. Thus, we applied SK-Hep-1 and used cell counting kit 8 (CCK8), lactate dehydrogenase (LDH), colony formation 5-ethynyl-20-deoxyuridine (EdU)...
Generally, essential oils and components of interest are extracted from plants using organic solvent, distillation, ultrasound supercritical extraction methods. Ultrasonic (UE) has the advantage high efficiency, but its process is complicated it numerous variables. In this study, an L18-Hunter experimental design was applied for first time to investigate practicability applying UE Forsythia suspensa seed oil. Six potential high-risk variables, including numerical non-numeric types, were...
This study aimed to analyze the analgesic effect and related central mechanisms of CQ prescription on cancer invasion induced mirror image pain (CIIMIP)in model mice.In study, male BALB/c mice were randomly divided into normal group, operation control group (injected with 0.2 mL inactivated S180 sarcoma cell sap), sap right leg near greater trochanter femur) low dose (intraperitoneally injected 100 mg•kg⁻¹ basis mice), middle 150 high 200 mice). Mechanical withdraw threshold (MWT) lateral...
Ethnopharmacological relevance: As cis-diamminedichloroplatinum [cisplatin (CDDP)] may induce nephrotoxicity, its clinical application as an anticancer drug is seriously limited. Currently, the prevention and treatment of CDDP-induced nephrotoxicity are inadequate. In China, patients often opt for traditional Chinese medicine to mitigate nephrotoxicity. trials, Wuling San has been a significantly effective However, mechanisms action remain unclear.Aim studyThe objectives this investigation...