A5039361819- Neuroscience and Neuropharmacology Research
- Animal Vocal Communication and Behavior
- Trace Elements in Health
- Primate Behavior and Ecology
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Nicotinic Acetylcholine Receptors Study
- Biochemical Analysis and Sensing Techniques
- Retinal Development and Disorders
- Neural dynamics and brain function
- Animal Behavior and Reproduction
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Galectins and Cancer Biology
- Biochemical effects in animals
- Neurological Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
Ilia State University
2014-2024
National Center for Disease Control and Public Health
2022
Sechenov University
2022
King Abdullah University of Science and Technology
2022
GTx (United States)
2019-2020
Tbilisi State Medical University
2018
Tbilisi State University
2008-2012
Czech Academy of Sciences, Institute of Physiology
2007-2008
Georgian National Academy of Sciences
1998-2007
University of Cambridge
1995-2000
Using unsupervised metabolomics, we defined the complex metabolic conditions in cortex of a mouse model Rett syndrome (RTT). RTT, which represents cause mental and cognitive disabilities females, results profound impairment with autistic features, motor disabilities, seizures, gastrointestinal problems, cardiorespiratory irregularities. Typical RTT originates from mutations X-chromosomal methyl-CpG-binding-protein-2 (Mecp2) gene, encodes transcriptional modulator. It then causes deregulation...
Fabrication and characterization of amperometric bienzyme L-glutamate sensitive microelectrodes are the prerequisite for monitoring changes concentration at glutamate-secreting cell cultures. The design glutamate is based on incorporating oxidase horseradish peroxidase into a redox-hydrogel containing PVI19-dmeOs as redox mediator immobilizing this system onto surface platinum microdisk electrodes using dip-coating procedure. For measurements L-glutamate, these hydrogel-based can be operated...
The intermediate and medial hyperstriatum ventrale (IMHV) of the chick forebrain is a site recognition memory for learning process imprinting. results reported here demonstrate that neural cell adhesion molecules (NCAMs) play time-dependent role in this memory. Dark-reared chicks were trained, tested, assigned preference score as measure learning. Chicks with high scores designated good learners those lower scores, poor learners. Controls untrained. Tissue was removed, 9.5 hr or 24 after...
The intermediate and medial mesopallium (IMM) of the domestic chick forebrain has previously been shown to be a memory system for visual imprinting. Learning-related changes occur in certain plasma membrane mitochondrial proteins IMM. Two-dimensional gel electrophoresis/mass spectrometry employed identify more comprehensively learning-related expression membrane-mitochondrial fraction IMM 24 h after training. We inquired whether amounts these control region (posterior pole nidopallium, PPN)...
Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms normal brain into an epileptic one. Prevention of subject intensive research. Currently, there are no clinically approved drugs that can act preventive medication. Our previous studies have revealed highly promising antiepileptogenic properties compound-myo-inositol (MI) and the present research broadens results...
Abstract Previous work has identified the intermediate and medial part of hyperstriatum ventrale (IMHV) as a region chick brain storing information acquired through learning process imprinting. We have examined in this changes expression candidate genes involved memory. Chicks were exposed to rotating red box strength their preference for it, measure learning, determined. Brain samples removed ≈24 h after training. Candidate whose expressions different IMHV derived from strongly imprinted...
Rett syndrome (RTT) is a genetic neurodevelopmental disorder with mutations in the X-chromosomal MECP2 (methyl-CpG-binding protein 2) gene. Most patients are young girls. For 7-18 months after birth, they hardly present any symptoms; later develop mental problems, lack of communication, irregular sleep and breathing, motor dysfunction, hand stereotypies, seizures. The complex pathology involves mitochondrial structure function. Mecp2-/y hippocampal astrocytes show increased contents. Neurons...
The role of calcium/calmodulin-dependent protein kinase II (CaMKII) in the recognition memory visual imprinting was investigated. Domestic chicks were exposed to a training stimulus and learning strength measured. Trained chicks, together with untrained killed either 1 h or 24 after training. intermediate medial hyperstriatum ventrale/mesopallium (IMHV/IMM), forebrain storage site, removed control brain region, posterior pole neostriatum/nidopallium (PPN). Amounts membrane total alphaCaMKII...
Inositols play significant roles in biological systems. Myo-inositol (MI), the most prevalent isomer, functions as an osmolyte and mediates cell signal transduction. Other notable isomers include Scyllo-inositol (SCI) D-Chiro-inositol (DCHI). Our previous investigations have highlighted MI's potential antiepileptogenic effects, although its exact mechanisms of action during epileptogenesis remain unclear. A critical, unexplored area is how inositols interact with proteins. Additionally,...
Src is a non-receptor tyrosine kinase participating in range of neuronal processes, including synaptic plasticity. We have recently shown that the amounts total and its two phosphorylated forms, at tyrosine-416 (activated) tyrosine-527 (inhibited), undergoes time-dependent, region-specific learning-related changes domestic chick forebrain after visual imprinting. These occur intermediate medial mesopallium (IMM), site memory formation for imprinting, but not posterior pole nidopallium (PPN),...