A5062789661- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Trace Elements in Health
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Pregnancy and preeclampsia studies
- GABA and Rice Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Ion channel regulation and function
- Cannabis and Cannabinoid Research
- Birth, Development, and Health
- Cassava research and cyanide
- Folate and B Vitamins Research
- Biochemical effects in animals
- Medicinal Plants and Neuroprotection
Ilia State University
2010-2024
Universität Hamburg
2006-2015
Allegheny General Hospital
2011
Allegheny-Singer Research Institute
2011
Tbilisi State University
2011
Martini-Klinik
2006
University Medical Center Hamburg-Eppendorf
2006
Humboldt-Universität zu Berlin
2003
Abstract The cell adhesion molecule, CHL1, like its close homologue L1, is important for normal brain development and function. In this study, we analysed the functional role of CHL1 in synaptic transmission CA1 region hippocampus using juvenile CHL1‐deficient (CHL1–/–) wild‐type (CHL1+/+) mice. Inhibitory postsynaptic currents evoked pyramidal cells by minimal stimulation perisomatically projecting interneurons were increased CHL1–/– mice compared with littermates. Also, long‐term...
In humans, deletions/mutations in the CHL1/CALL gene are associated with mental retardation and schizophrenia. Juvenile CHL1-deficient (CHL1(-/-) ) mice have been shown to display abnormally high numbers of parvalbumin-expressing (PV(+) hippocampal interneurons and, as adults, behavioral traits observed neuropsychiatric disorders. Here, we addressed question whether inhibitory synaptic plasticity CHL1(-/-) mouse affected during brain maturation adulthood. We found that hippocampal, but not...
Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms normal brain into an epileptic one. Prevention of subject intensive research. Currently, there are no clinically approved drugs that can act preventive medication. Our previous studies have revealed highly promising antiepileptogenic properties compound-myo-inositol (MI) and the present research broadens results...
Epilepsy is one of the most devastating neurological diseases and despite significant efforts there no cure available. Occurrence spontaneous seizures in epilepsy preceded by numerous functional structural pathophysiological reorganizations brain-a process called epileptogenesis. Treatment strategies targeting this may be efficient for preventing recurrent (SRS) epilepsy, or modification disease progression. We have previously shown that (i) myoinositol (MI) pretreatment significantly...
Identification of compounds preventing or modifying the biochemical changes that underlie epileptogenesis process and understanding mechanism their action are great importance. We have previously shown myoinositol (MI) daily treatment for 28 days prevents certain triggered by kainic acid (KA) induced status epilepticus (SE). However in these studies we not detected any effects MI on first day after SE. In present study broadened our research focused other molecular morphological at early...