A5027522449- Folate and B Vitamins Research
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological Complications and Syndromes
- Metabolism and Genetic Disorders
- Infective Endocarditis Diagnosis and Management
- Esophageal and GI Pathology
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Retinal and Optic Conditions
- Lipoproteins and Cardiovascular Health
- Cardiovascular Issues in Pregnancy
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Blood properties and coagulation
- Cardiac Ischemia and Reperfusion
- HIV-related health complications and treatments
- Pregnancy and preeclampsia studies
München Klinik
2019-2020
University Hospital of Bern
2013-2020
Royal Brompton Hospital
2019
Imperial College London
2019
Helios Kliniken
2019
Paracelsus Medical University
2005-2016
Saint John of God Hospital
2016
Hospital of the Brothers of St. John of God
2016
University of Bern
2014-2015
Liverpool Heart and Chest Hospital
2013
There is strong and consistent evidence that oxidative stress crucially involved in the development of atherosclerotic vascular disease. Overproduction reactive oxygen species (ROS) mitochondria an unifying mechanism underlies micro- macrovascular Given central role energy ROS production, mitochondrial DNA (mtDNA) obvious candidate for genetic susceptibility studies on processes. We therefore examined association between mtDNA haplogroups coronary artery disease (CAD) as well diabetic...
Background The pivotal role of mitochondria in energy production and free radical generation suggests that the mitochondrial genome could have an important influence on expression multifactorial age related diseases. Substitution T to C at nucleotide position 16189 hypervariable D-loop control region (CR) DNA (mtDNA) has attracted research interest because its suspected association with various aim present study was compare frequency this polymorphism CR mtDNA patients coronary artery...
Purpose: To report the consequences of endoluminal deployment stent-grafts in thoracic aorta with intentional occlusion left subclavian artery. Case Reports: Three patients an aortic type-B dissection and 1 a aneurysm were treated endoluminally Talent implanted over ostium artery without prior surgical subclavian-carotid transposition. The primary intimal tears sealed degenerative excluded; blood pressure arm was significantly diminished immediately after stent-graft released, but adequate...
Epidemiological case-control studies have revealed associations between mitochondrial haplogroups and the onset and/or progression of various multifactorial diseases. For instance, haplogroup T was previously shown to be associated with vascular diseases, including coronary artery disease diabetic retinopathy. In contrast, H, most frequent in Europe, is often found more prevalent healthy control subjects than patient study groups. However, justifications for assumption that are functionally...
Ischemia-reperfusion has been reported to be associated with augmented oxidative stress in the course of surgery, which might causally involved onset atrial fibrillation (AF), most common arrhythmia after cardiac surgery. We hypothesized that supplementation antioxidants and n-3 polyunsaturated fatty acids (n-3 PUFAs) lower incidence AF following coronary artery bypass graft (CABG) In present study, by monitoring CABG we analyzed efficacy vitamins (ascorbic acid α-tocopherol) and/or PUFAs...
The vitamin B complex comprises 8 different water-soluble constituents that humans must sequester from the diet. This pilot study compared natural versus synthetic complexes for their bioavailability, accumulation, and impact on antioxidants, homocysteine levels, oxidative stress. We conducted a double-blind randomized clinical trial with thirty healthy participants. They were randomly assigned to group N (natural) S (synthetic). Vitamin was ingested daily 6 weeks in range of about 2.5 times...
Background— Cardiac surgery with cardiopulmonary bypass is associated mechanical manipulation of the ascending aorta that occasionally leads to type A aortic dissection (AAD). Methods and Results— One hundred three patients surgical repair for AAD following nonaortic cardiac were identified. With use logistic regression modeling, coronary artery (CABG), either isolated or combined another procedure in initial operation, was significantly higher operative mortality comparison non-CABG...
Hyperhomocysteinemia is associated with arterial hypertension and endothelial dysfunction in healthy humans. Placebo-controlled vitamin intervention studies cannot distinguish intrinsic actions of homocysteine (tHcy) folate concentrations on the endothelium. The present two-period crossover study investigates effects tHcy lowering through oral folic acid antioxidant status resistance vessel reactivity patients established coronary artery disease (CAD). We investigated 27 male...
Objective: Aortic dissection is a potentially life-threatening condition and may follow surgical interventions as complication with distinct presentation high mortality. Information on the incidence etiology of aortic dissections following cardiac surgery sparse inconsistent. The true this entity so far have been underestimated. Methods: Data 223 operations thoracic aorta performed exclusively at our institution between January 1990 May 2001 were analysed for clinical prognostic features....
OBJECTIVES: Use of the Freedom SOLO (SOLO) stentless aortic bioprosthesis is associated with a unique, and as yet unexplained, observation postoperative low platelet count. Potential causes include valve design, tissue chemicals used for anticalcification treatment. This study compares response to mechanical, stented, sutureless prostheses. METHODS: In total, 1587 patients receiving mechanical ATS (n = 199), stented Perimount Magna (Perimount, n 911), 3f Enable 34) Perceval S 48), Pericarbon...