To evaluate the long-term safety and efficacy of intranasal esketamine in patients with treatment-resistant depression from Asian subgroup SUSTAIN-2 study.SUSTAIN-2 was a phase 3, open-label, single-arm, multicenter study comprising 4-week screening, induction, 48-week optimization/maintenance, follow-up (upon discontinuation) phase. Patients received plus an oral antidepressant during treatment period.The incidence ≥ 1 serious treatment-emergent adverse event (TEAE) among 78 subjects...

Sudden discontinuation from antipsychotic treatment is a common occurrence in patients with schizophrenia. Lower rates of relapse could be expected for discontinuing longer-acting formulations vs their shorter-acting equivalents.To compare and time-to-relapse between the active (analogous to adherent patients) placebo non-adherent real-world) arms three different paliperidone (oral extended release [paliperidone ER], palmitate once monthly [PP1M], [PP3M] long-acting injectables).Data...

Post hoc analyses (two single-arm studies) were conducted to determine the impact of once-monthly injection paliperidone palmitate on functioning in adult patients with schizophrenia Asia-Pacific region.Study 1 enrolled hospitalized acute exacerbation schizophrenia, and study 2 recently diagnosed unsatisfactorily treated oral antipsychotics. Patients received palmitate, 150 mg eq. day 1, 100 8, then once monthly (50-150 eq.) (study days 36 64; 2, 18 months). Functional status was evaluated...

Background: The use of long-acting injectable antipsychotics in recently diagnosed schizophrenia remains less explored. We evaluated the efficacy and safety paliperidone palmitate once-monthly (PP1M) treatment adult patients with vs. chronic schizophrenia.Research design methods: These post-hoc analyses included two multicenter studies. Study 1 (NCT01527305) enrolled (≤5 years) (>5 patients; 2 (NCT01051531) only. Recently were further sub-grouped into ≤2 years or 2–5 years. primary endpoint...

An Asia-Pacific expert consensus defined treatment-resistant depression (TRD) as failure of ≥2 antidepressants given at adequate doses for 6-8 weeks during a major depressive episode. A survey examined how TRD was being diagnosed in real-world practices across Asia. panel then interpreted the results and provided practical recommendations.Between March July 2018, 246 clinicians from Hong Kong, Japan, Mainland China, South Korea, Taiwan were surveyed on they identified patients according to...

The widespread adoption of social networking and cloud computing has transformed today's Internet to a trove personal information. As consequence, data breaches are expected increase in gravity occurrence. To counteract unintended disclosure, great deal effort been dedicated devising methods for uncovering privacy leaks. Existing solutions, however, have not addressed the time- data-intensive nature leak detection. shift from hardware-specific implementation software-based solutions is core...

Consensus is lacking on the management of treatment-resistant depression (TRD), resulting in significant variations how TRD patients are being managed real-world practice. A survey explored clinicians across Asia, followed by an expert panel that interpreted results and provided recommendations could be clinical settings.Between March July 2018, 246 from Hong Kong, Japan, Mainland China, South Korea, Taiwan completed a related to their treatment approaches for TRD.The showed physicians using...

We report an implementation of a 32-bit DLX microprocessor capable operating in dual core environment. The processor was modified for it to be atomic instructions, requirement environment simulated using similar acting as pseudo slave core. resulting can then interfaced with another instance the same function processor. It also DSP co-processor that is compatible handshaking protocols yielded power reduction 17.9% (due more efficient register file) and area overhead 23% additional blocks...

To evaluate the differences in efficacy and safety outcomes acute exacerbating schizophrenia patients between 2 subgroups (≤1 week >1 week), differing time interval from hospitalization to of initiation once-monthly paliperidone palmitate.PREVAIL was a multicenter, single-arm, open-label, prospective Phase IV study hospitalized Asian (either sex, aged 18-65 years) diagnosed with (Diagnostic Statistical Manual Mental Disorders, Fourth Edition). Change baseline 13 primary (Positive Negative...

Background: In this post hoc analysis in patients recently diagnosed (≤5 years) with schizophrenia, the effect on hospitalization risk after switching from oral antipsychotic to once-monthly paliperidone palmitate (PP1M) was evaluated.Research design and methods: Change following PP1M initiation among antipsychotics assessed using prescription sequence symmetry analysis. Hospitalization expressed as an adjusted ratio (ASR) of number hospitalized prior initiation/post initiation. Cumulative...

To evaluate the long-term efficacy and safety of three-monthly paliperidone palmitate (PP3M) in Asian patients with stable schizophrenia a naturalistic setting.Asian recruited between May 2016 March 2018 from prospective, single-arm, non-randomized, open-label, multi-national REMISSIO study were analyzed. Patients received PP3M over 12 months following ≥ 4 treatment one-monthly palmitate. The primary endpoint was proportion who achieved symptomatic remission. Other endpoints changes Positive...

In the Philippines, efforts are being made to address inaccessibility of Internet access by 42% population. One such service installs Wi-Fi hotspots in public areas and government buildings. To make more effective, data on point deployment is vital. While there exist platforms for crowdsourced submission as WiGLE, methods dedicated wardriving, these can be costly, infrequent, easily become outdated. Regular collection points necessary better accuracy. For regular, inexpensive, frequent...

Existing algorithms for orienting sensors in directional sensor networks have primarily concerned themselves with the problem of maximizing number covered targets, assuming that target identification as a non-issue. Such an assumption however, does not hold true all situations. In this paper, distributed heuristic algorithm choosing active and them goal balancing coverage identifiability is presented. The performance verified via simulations, shown through simulations to confer increased...

Energy harvesting wireless sensor network nodes would not be able to operate without duty cycling. In TinyOS, cycling is supported through Low Power Listening or LPL. LPL sender-centric: the longer wakeup interval, more power a receiver saves, at cost of energy per transmission for sender. Due limitations storage technologies, there limit sender interval which senders could support. Currently, derived computationally experimentally. Computational derivation overly conservative, while manual...

Energy harvesting wireless sensor network nodes would not be able to operate without duty cycling. In TinyOS, cycling is supported through Low Power Listening or LPL. LPL sender-centric: the longer wakeup interval, more power a receiver saves, at cost of energy per transmission for sender. Due limitations storage technologies, there limit sender interval which senders could support. Currently, derived computationally experimentally. Computational derivation overly conservative, while manual...

Existing algorithms for orienting sensors in directional sensor networks have primarily concerned themselves with the problem of maximizing number covered targets, assuming that target identification as a non-issue. Such an assumption however, does not hold true all situations. In this paper, three heuristic choosing active and them goal balancing coverage identifiability are presented. The first algorithm is parameterizable, allowing users to specify desired level trade-off between...

Electronic devices such as CCTVs and GPS trackers are becoming more prevalent in public utility vehicles. These electronic produce data that can be aggregated processed to generate insights regarding the service quality provided by transportation systems. We describe a methodology for processing CCTV-produced videos logs, utilize it perform first order, limited assessment of Philippines' Service Contracting Program, which ran during COVID-19 pandemic. Our analyses uncovered vast...